Heterogeneity in regional changes in body composition induced by androgen deprivation therapy in prostate cancer patients: potential impact on bone health—the BLADE study
Background It is not clear whether changes in body composition induced by androgen deprivation therapy (ADT) in prostate cancer (PC) patients are uniform or vary in the different body districts and whether regional lean body mass (LBM) and fat body mass (FBM) could have an impact on bone health. Obj...
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| Veröffentlicht in: | Journal of endocrinological investigation 2024-02, Vol.47 (2), p.335-343 |
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| creator | Dalla Volta, A. Palumbo, C. Zamboni, S. Mazziotti, G. Triggiani, L. Zamparini, M. Maffezzoni, F. Rinaudo, L. Bergamini, M. Di Meo, N. Caramella, I. Valcamonico, F. Borghetti, P. Guerini, A. Farina, D. Antonelli, A. Simeone, C. Berruti, A. |
| description | Background
It is not clear whether changes in body composition induced by androgen deprivation therapy (ADT) in prostate cancer (PC) patients are uniform or vary in the different body districts and whether regional lean body mass (LBM) and fat body mass (FBM) could have an impact on bone health.
Objective
To prospectively evaluate the regional changes in LBM and FBM in PC patients submitted to degarelix; to explore the relationship of regional body composition and bone mineral density (BMD) and bone turnover markers.
Design, setting, and participants
29 consecutive non metastatic PC patients enrolled from 2017 to 2019. FBM, LBM and bone mineral density (BMD) evaluated by dual-energy x-ray absorptiometry (DXA) at baseline and after 12-month of ADT. Alkaline phosphate (ALP) and C-terminal telopeptide of type I collagen (CTX) assessed at baseline, 6 and 12 months.
Intervention
All patients underwent degarelix administration.
Outcome measurements and statistical analysis
T
-test or sign test and Pearson or Spearman test for continuous variables were used when indicated.
Results and limitations
Median percent increase in FBM ranged from + 14.5% in trunk to + 25.4% in the left leg after degarelix. LBM changes varied from + 2% in the trunk to − 4.9% in the right arm. LBM in both arms and legs and their variations after degarelix directly correlated with ALP and inversely correlated with CTX. Lean mass of limbs, trunk and legs significantly correlated with BMD of the hip, lean mass of the trunk significantly correlated with spine BMD. These are post-hoc analysis of a prospective study and this is the main limitation.
Conclusions
an heterogeneous change in body composition among body district is observed after ADT and bone turnover is influenced by lean mass and its variation. A supervised physical activity is crucial to maintain general physical performance and preserving bone health. |
| doi_str_mv | 10.1007/s40618-023-02150-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10859344</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2925072411</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-9adf8cca34b068b00e2b0260a31578a3103eb3de26781b01d3a6afb1bd534ff33</originalsourceid><addsrcrecordid>eNp9Ustu1TAQjRCIlsIPsECW2LAJ2HEeDhtUSqFIV2IDa8uPyY2rJA62Uyld8RF8Bl_FlzD33lIKCxa2R3POnJnxTJY9ZfQlo7R5FUtaM5HTguNhFc2v72XHrCloLrio79-xj7JHMV5SyhsumofZEW_KSrScHWc_LiBB8FuYwKWVuIkE2Do_qYGYXk1biDuf9nYlxo-zjy4hij67GLBEr0RNdh9PLMzBXak9nnoIat7rzcHHpBIQoyYDgczIgCnF12T2CQ2Hqdw4K5OI32WagPSghtT__PYdZcjbzem7cxLTYtfH2YNODRGe3Lwn2Zf355_PLvLNpw8fz043uSmbKuWtsp0wRvFS01poSqHQtKip4qxqBN6Ug-YWiroRTFNmuapVp5m2FS-7jvOT7M1Bd170CNZglUENEtsbVVilV07-jUyul1t_JRkVVcvLEhVe3CgE_3WBmOToooFhUBP4JcpC8LYoa8FqpD7_h3rpl4ADQFZbVLQpSsaQVRxYBr8zBuhuq2FU7rZBHrZB4jbI_TbIawx6dreP25Df40cCPxAiQjjs8Cf3f2R_ATPHxnU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2925072411</pqid></control><display><type>article</type><title>Heterogeneity in regional changes in body composition induced by androgen deprivation therapy in prostate cancer patients: potential impact on bone health—the BLADE study</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Dalla Volta, A. ; Palumbo, C. ; Zamboni, S. ; Mazziotti, G. ; Triggiani, L. ; Zamparini, M. ; Maffezzoni, F. ; Rinaudo, L. ; Bergamini, M. ; Di Meo, N. ; Caramella, I. ; Valcamonico, F. ; Borghetti, P. ; Guerini, A. ; Farina, D. ; Antonelli, A. ; Simeone, C. ; Berruti, A.</creator><creatorcontrib>Dalla Volta, A. ; Palumbo, C. ; Zamboni, S. ; Mazziotti, G. ; Triggiani, L. ; Zamparini, M. ; Maffezzoni, F. ; Rinaudo, L. ; Bergamini, M. ; Di Meo, N. ; Caramella, I. ; Valcamonico, F. ; Borghetti, P. ; Guerini, A. ; Farina, D. ; Antonelli, A. ; Simeone, C. ; Berruti, A.</creatorcontrib><description>Background
It is not clear whether changes in body composition induced by androgen deprivation therapy (ADT) in prostate cancer (PC) patients are uniform or vary in the different body districts and whether regional lean body mass (LBM) and fat body mass (FBM) could have an impact on bone health.
Objective
To prospectively evaluate the regional changes in LBM and FBM in PC patients submitted to degarelix; to explore the relationship of regional body composition and bone mineral density (BMD) and bone turnover markers.
Design, setting, and participants
29 consecutive non metastatic PC patients enrolled from 2017 to 2019. FBM, LBM and bone mineral density (BMD) evaluated by dual-energy x-ray absorptiometry (DXA) at baseline and after 12-month of ADT. Alkaline phosphate (ALP) and C-terminal telopeptide of type I collagen (CTX) assessed at baseline, 6 and 12 months.
Intervention
All patients underwent degarelix administration.
Outcome measurements and statistical analysis
T
-test or sign test and Pearson or Spearman test for continuous variables were used when indicated.
Results and limitations
Median percent increase in FBM ranged from + 14.5% in trunk to + 25.4% in the left leg after degarelix. LBM changes varied from + 2% in the trunk to − 4.9% in the right arm. LBM in both arms and legs and their variations after degarelix directly correlated with ALP and inversely correlated with CTX. Lean mass of limbs, trunk and legs significantly correlated with BMD of the hip, lean mass of the trunk significantly correlated with spine BMD. These are post-hoc analysis of a prospective study and this is the main limitation.
Conclusions
an heterogeneous change in body composition among body district is observed after ADT and bone turnover is influenced by lean mass and its variation. A supervised physical activity is crucial to maintain general physical performance and preserving bone health.</description><identifier>ISSN: 1720-8386</identifier><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/s40618-023-02150-z</identifier><identifier>PMID: 37458931</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Absorptiometry, Photon ; Androgen Antagonists - adverse effects ; Androgens ; Arm ; Body Composition ; Body mass ; Bone composition ; Bone Density ; Bone mass ; Bone mineral density ; Bone turnover ; Collagen (type I) ; Dual energy X-ray absorptiometry ; Endocrinology ; Fat body ; Humans ; Internal Medicine ; Lean body mass ; Leg ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metastases ; Original ; Original Article ; Physical activity ; Prospective Studies ; Prostate cancer ; Prostatic Neoplasms - drug therapy ; Statistical analysis</subject><ispartof>Journal of endocrinological investigation, 2024-02, Vol.47 (2), p.335-343</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-9adf8cca34b068b00e2b0260a31578a3103eb3de26781b01d3a6afb1bd534ff33</citedby><cites>FETCH-LOGICAL-c475t-9adf8cca34b068b00e2b0260a31578a3103eb3de26781b01d3a6afb1bd534ff33</cites><orcidid>0000-0002-3956-0043</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40618-023-02150-z$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40618-023-02150-z$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37458931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dalla Volta, A.</creatorcontrib><creatorcontrib>Palumbo, C.</creatorcontrib><creatorcontrib>Zamboni, S.</creatorcontrib><creatorcontrib>Mazziotti, G.</creatorcontrib><creatorcontrib>Triggiani, L.</creatorcontrib><creatorcontrib>Zamparini, M.</creatorcontrib><creatorcontrib>Maffezzoni, F.</creatorcontrib><creatorcontrib>Rinaudo, L.</creatorcontrib><creatorcontrib>Bergamini, M.</creatorcontrib><creatorcontrib>Di Meo, N.</creatorcontrib><creatorcontrib>Caramella, I.</creatorcontrib><creatorcontrib>Valcamonico, F.</creatorcontrib><creatorcontrib>Borghetti, P.</creatorcontrib><creatorcontrib>Guerini, A.</creatorcontrib><creatorcontrib>Farina, D.</creatorcontrib><creatorcontrib>Antonelli, A.</creatorcontrib><creatorcontrib>Simeone, C.</creatorcontrib><creatorcontrib>Berruti, A.</creatorcontrib><title>Heterogeneity in regional changes in body composition induced by androgen deprivation therapy in prostate cancer patients: potential impact on bone health—the BLADE study</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><addtitle>J Endocrinol Invest</addtitle><description>Background
It is not clear whether changes in body composition induced by androgen deprivation therapy (ADT) in prostate cancer (PC) patients are uniform or vary in the different body districts and whether regional lean body mass (LBM) and fat body mass (FBM) could have an impact on bone health.
Objective
To prospectively evaluate the regional changes in LBM and FBM in PC patients submitted to degarelix; to explore the relationship of regional body composition and bone mineral density (BMD) and bone turnover markers.
Design, setting, and participants
29 consecutive non metastatic PC patients enrolled from 2017 to 2019. FBM, LBM and bone mineral density (BMD) evaluated by dual-energy x-ray absorptiometry (DXA) at baseline and after 12-month of ADT. Alkaline phosphate (ALP) and C-terminal telopeptide of type I collagen (CTX) assessed at baseline, 6 and 12 months.
Intervention
All patients underwent degarelix administration.
Outcome measurements and statistical analysis
T
-test or sign test and Pearson or Spearman test for continuous variables were used when indicated.
Results and limitations
Median percent increase in FBM ranged from + 14.5% in trunk to + 25.4% in the left leg after degarelix. LBM changes varied from + 2% in the trunk to − 4.9% in the right arm. LBM in both arms and legs and their variations after degarelix directly correlated with ALP and inversely correlated with CTX. Lean mass of limbs, trunk and legs significantly correlated with BMD of the hip, lean mass of the trunk significantly correlated with spine BMD. These are post-hoc analysis of a prospective study and this is the main limitation.
Conclusions
an heterogeneous change in body composition among body district is observed after ADT and bone turnover is influenced by lean mass and its variation. A supervised physical activity is crucial to maintain general physical performance and preserving bone health.</description><subject>Absorptiometry, Photon</subject><subject>Androgen Antagonists - adverse effects</subject><subject>Androgens</subject><subject>Arm</subject><subject>Body Composition</subject><subject>Body mass</subject><subject>Bone composition</subject><subject>Bone Density</subject><subject>Bone mass</subject><subject>Bone mineral density</subject><subject>Bone turnover</subject><subject>Collagen (type I)</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Endocrinology</subject><subject>Fat body</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lean body mass</subject><subject>Leg</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metastases</subject><subject>Original</subject><subject>Original Article</subject><subject>Physical activity</subject><subject>Prospective Studies</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Statistical analysis</subject><issn>1720-8386</issn><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9Ustu1TAQjRCIlsIPsECW2LAJ2HEeDhtUSqFIV2IDa8uPyY2rJA62Uyld8RF8Bl_FlzD33lIKCxa2R3POnJnxTJY9ZfQlo7R5FUtaM5HTguNhFc2v72XHrCloLrio79-xj7JHMV5SyhsumofZEW_KSrScHWc_LiBB8FuYwKWVuIkE2Do_qYGYXk1biDuf9nYlxo-zjy4hij67GLBEr0RNdh9PLMzBXak9nnoIat7rzcHHpBIQoyYDgczIgCnF12T2CQ2Hqdw4K5OI32WagPSghtT__PYdZcjbzem7cxLTYtfH2YNODRGe3Lwn2Zf355_PLvLNpw8fz043uSmbKuWtsp0wRvFS01poSqHQtKip4qxqBN6Ug-YWiroRTFNmuapVp5m2FS-7jvOT7M1Bd170CNZglUENEtsbVVilV07-jUyul1t_JRkVVcvLEhVe3CgE_3WBmOToooFhUBP4JcpC8LYoa8FqpD7_h3rpl4ADQFZbVLQpSsaQVRxYBr8zBuhuq2FU7rZBHrZB4jbI_TbIawx6dreP25Df40cCPxAiQjjs8Cf3f2R_ATPHxnU</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Dalla Volta, A.</creator><creator>Palumbo, C.</creator><creator>Zamboni, S.</creator><creator>Mazziotti, G.</creator><creator>Triggiani, L.</creator><creator>Zamparini, M.</creator><creator>Maffezzoni, F.</creator><creator>Rinaudo, L.</creator><creator>Bergamini, M.</creator><creator>Di Meo, N.</creator><creator>Caramella, I.</creator><creator>Valcamonico, F.</creator><creator>Borghetti, P.</creator><creator>Guerini, A.</creator><creator>Farina, D.</creator><creator>Antonelli, A.</creator><creator>Simeone, C.</creator><creator>Berruti, A.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3956-0043</orcidid></search><sort><creationdate>20240201</creationdate><title>Heterogeneity in regional changes in body composition induced by androgen deprivation therapy in prostate cancer patients: potential impact on bone health—the BLADE study</title><author>Dalla Volta, A. ; Palumbo, C. ; Zamboni, S. ; Mazziotti, G. ; Triggiani, L. ; Zamparini, M. ; Maffezzoni, F. ; Rinaudo, L. ; Bergamini, M. ; Di Meo, N. ; Caramella, I. ; Valcamonico, F. ; Borghetti, P. ; Guerini, A. ; Farina, D. ; Antonelli, A. ; Simeone, C. ; Berruti, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-9adf8cca34b068b00e2b0260a31578a3103eb3de26781b01d3a6afb1bd534ff33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Absorptiometry, Photon</topic><topic>Androgen Antagonists - adverse effects</topic><topic>Androgens</topic><topic>Arm</topic><topic>Body Composition</topic><topic>Body mass</topic><topic>Bone composition</topic><topic>Bone Density</topic><topic>Bone mass</topic><topic>Bone mineral density</topic><topic>Bone turnover</topic><topic>Collagen (type I)</topic><topic>Dual energy X-ray absorptiometry</topic><topic>Endocrinology</topic><topic>Fat body</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Lean body mass</topic><topic>Leg</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Metastases</topic><topic>Original</topic><topic>Original Article</topic><topic>Physical activity</topic><topic>Prospective Studies</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - drug therapy</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dalla Volta, A.</creatorcontrib><creatorcontrib>Palumbo, C.</creatorcontrib><creatorcontrib>Zamboni, S.</creatorcontrib><creatorcontrib>Mazziotti, G.</creatorcontrib><creatorcontrib>Triggiani, L.</creatorcontrib><creatorcontrib>Zamparini, M.</creatorcontrib><creatorcontrib>Maffezzoni, F.</creatorcontrib><creatorcontrib>Rinaudo, L.</creatorcontrib><creatorcontrib>Bergamini, M.</creatorcontrib><creatorcontrib>Di Meo, N.</creatorcontrib><creatorcontrib>Caramella, I.</creatorcontrib><creatorcontrib>Valcamonico, F.</creatorcontrib><creatorcontrib>Borghetti, P.</creatorcontrib><creatorcontrib>Guerini, A.</creatorcontrib><creatorcontrib>Farina, D.</creatorcontrib><creatorcontrib>Antonelli, A.</creatorcontrib><creatorcontrib>Simeone, C.</creatorcontrib><creatorcontrib>Berruti, A.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dalla Volta, A.</au><au>Palumbo, C.</au><au>Zamboni, S.</au><au>Mazziotti, G.</au><au>Triggiani, L.</au><au>Zamparini, M.</au><au>Maffezzoni, F.</au><au>Rinaudo, L.</au><au>Bergamini, M.</au><au>Di Meo, N.</au><au>Caramella, I.</au><au>Valcamonico, F.</au><au>Borghetti, P.</au><au>Guerini, A.</au><au>Farina, D.</au><au>Antonelli, A.</au><au>Simeone, C.</au><au>Berruti, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heterogeneity in regional changes in body composition induced by androgen deprivation therapy in prostate cancer patients: potential impact on bone health—the BLADE study</atitle><jtitle>Journal of endocrinological investigation</jtitle><stitle>J Endocrinol Invest</stitle><addtitle>J Endocrinol Invest</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>47</volume><issue>2</issue><spage>335</spage><epage>343</epage><pages>335-343</pages><issn>1720-8386</issn><issn>0391-4097</issn><eissn>1720-8386</eissn><abstract>Background
It is not clear whether changes in body composition induced by androgen deprivation therapy (ADT) in prostate cancer (PC) patients are uniform or vary in the different body districts and whether regional lean body mass (LBM) and fat body mass (FBM) could have an impact on bone health.
Objective
To prospectively evaluate the regional changes in LBM and FBM in PC patients submitted to degarelix; to explore the relationship of regional body composition and bone mineral density (BMD) and bone turnover markers.
Design, setting, and participants
29 consecutive non metastatic PC patients enrolled from 2017 to 2019. FBM, LBM and bone mineral density (BMD) evaluated by dual-energy x-ray absorptiometry (DXA) at baseline and after 12-month of ADT. Alkaline phosphate (ALP) and C-terminal telopeptide of type I collagen (CTX) assessed at baseline, 6 and 12 months.
Intervention
All patients underwent degarelix administration.
Outcome measurements and statistical analysis
T
-test or sign test and Pearson or Spearman test for continuous variables were used when indicated.
Results and limitations
Median percent increase in FBM ranged from + 14.5% in trunk to + 25.4% in the left leg after degarelix. LBM changes varied from + 2% in the trunk to − 4.9% in the right arm. LBM in both arms and legs and their variations after degarelix directly correlated with ALP and inversely correlated with CTX. Lean mass of limbs, trunk and legs significantly correlated with BMD of the hip, lean mass of the trunk significantly correlated with spine BMD. These are post-hoc analysis of a prospective study and this is the main limitation.
Conclusions
an heterogeneous change in body composition among body district is observed after ADT and bone turnover is influenced by lean mass and its variation. A supervised physical activity is crucial to maintain general physical performance and preserving bone health.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>37458931</pmid><doi>10.1007/s40618-023-02150-z</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-3956-0043</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1720-8386 |
| ispartof | Journal of endocrinological investigation, 2024-02, Vol.47 (2), p.335-343 |
| issn | 1720-8386 0391-4097 1720-8386 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10859344 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Absorptiometry, Photon Androgen Antagonists - adverse effects Androgens Arm Body Composition Body mass Bone composition Bone Density Bone mass Bone mineral density Bone turnover Collagen (type I) Dual energy X-ray absorptiometry Endocrinology Fat body Humans Internal Medicine Lean body mass Leg Male Medicine Medicine & Public Health Metabolic Diseases Metastases Original Original Article Physical activity Prospective Studies Prostate cancer Prostatic Neoplasms - drug therapy Statistical analysis |
| title | Heterogeneity in regional changes in body composition induced by androgen deprivation therapy in prostate cancer patients: potential impact on bone health—the BLADE study |
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