The macrophage-induced gene mig as a marker for clinical pathogenicity and in vitro virulence of Mycobacterium avium complex strains
The capacity of 20 Mycobacterium avium complex isolates to multiply intracellularly in human monocyte-derived macrophages was assessed and correlated to the clinical relevance of each isolate and its reactivity with several candidate genetic virulence markers. The strongest correlation with a virule...
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| Veröffentlicht in: | Infection and immunity 1998-09, Vol.66 (9), p.4549-4552 |
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| container_end_page | 4552 |
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| container_issue | 9 |
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| container_title | Infection and immunity |
| container_volume | 66 |
| creator | MEYER, M VON GRÜNBERG, P. W. R KNOOP, T HARTMANN, P PLUM, G |
| description | The capacity of 20 Mycobacterium avium complex isolates to multiply intracellularly in human monocyte-derived macrophages was assessed and correlated to the clinical relevance of each isolate and its reactivity with several candidate genetic virulence markers. The strongest correlation with a virulence phenotype was found for a conserved coding sequence of the macrophage-induced gene mig identified by a specific mig restriction fragment length polymorphism type. |
| doi_str_mv | 10.1128/iai.66.9.4549-4552.1998 |
| format | Article |
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| ispartof | Infection and immunity, 1998-09, Vol.66 (9), p.4549-4552 |
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| language | eng |
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| source | American Society for Microbiology; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Bacteriology Biological and medical sciences Biomarkers Fundamental and applied biological sciences. Psychology Genes, Bacterial Genetics Humans Macrophages - microbiology Microbiology Molecular and Cellular Pathogenesis Mycobacterium avium Complex - genetics Mycobacterium avium Complex - pathogenicity Mycobacterium avium-intracellulare Infection - metabolism Mycobacterium avium-intracellulare Infection - physiopathology Virulence |
| title | The macrophage-induced gene mig as a marker for clinical pathogenicity and in vitro virulence of Mycobacterium avium complex strains |
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