Clinical Multigene Panel Testing Identifies Racial and Ethnic Differences in Germline Pathogenic Variants Among Patients With Early-Onset Colorectal Cancer

The early-onset colorectal cancer (EOCRC) burden differs across racial/ethnic groups, yet the role of germline genetic predisposition in EOCRC disparities remains uncharacterized. We defined the prevalence and spectrum of inherited colorectal cancer (CRC) susceptibility gene variations among patient...

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Veröffentlicht in:	Journal of clinical oncology 2023-09, Vol.41 (26), p.4279-4289
Hauptverfasser:	Seagle, Hannah M, Keller, Samantha R, Tavtigian, Sean V, Horton, Carolyn, Holowatyj, Andreana N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biology of Neoplasia Colorectal Neoplasms - pathology Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Genetic Predisposition to Disease Genetic Testing Germ-Line Mutation Humans Middle Aged Young Adult
Online-Zugang:	Volltext
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