Biomonitoring of Dietary Mycotoxin Exposure and Associated Impact on the Gut Microbiome in Nigerian Infants
Mycotoxins are toxic chemicals that adversely affect human health. Here, we assessed the influence of mycotoxin exposure on the longitudinal development of early life intestinal microbiota of Nigerian neonates and infants (NIs). Human biomonitoring assays based on liquid chromatography tandem mass s...
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| Veröffentlicht in: | Environmental science & technology 2024-02, Vol.58 (5), p.2236-2246 |
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| creator | Ayeni, Kolawole I. Seki, David Pjevac, Petra Hausmann, Bela Krausová, Magdaléna Braun, Dominik Wisgrill, Lukas Berry, David Warth, Benedikt Ezekiel, Chibundu N. |
| description | Mycotoxins are toxic chemicals that adversely affect human health. Here, we assessed the influence of mycotoxin exposure on the longitudinal development of early life intestinal microbiota of Nigerian neonates and infants (NIs). Human biomonitoring assays based on liquid chromatography tandem mass spectrometry were applied to quantify mycotoxins in breast milk (n = 68) consumed by the NIs, their stool (n = 82), and urine samples (n = 15), which were collected longitudinally from month 1–18 postdelivery. Microbial community composition was characterized by 16S rRNA gene amplicon sequencing of stool samples and was correlated to mycotoxin exposure patterns. Fumonisin B1 (FB1), FB2, and alternariol monomethyl ether (AME) were frequently quantified in stool samples between months 6 and 18. Aflatoxin M1 (AFM1), AME, and citrinin were quantified in breast milk samples at low concentrations. AFM1, FB1, and ochratoxin A were quantified in urine samples at relatively high concentrations. Klebsiella and Escherichia/Shigella were dominant in very early life stool samples (month 1), whereas Bifidobacterium was dominant between months 3 and 6. The total mycotoxin levels in stool were significantly associated with NIs’ gut microbiome composition (PERMANOVA, p < 0.05). However, no significant correlation was observed between specific microbiota and the detection of certain mycotoxins. Albeit a small cohort, this study demonstrates that mycotoxins may influence early life gut microbiome composition. |
| doi_str_mv | 10.1021/acs.est.3c07786 |
| format | Article |
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Here, we assessed the influence of mycotoxin exposure on the longitudinal development of early life intestinal microbiota of Nigerian neonates and infants (NIs). Human biomonitoring assays based on liquid chromatography tandem mass spectrometry were applied to quantify mycotoxins in breast milk (n = 68) consumed by the NIs, their stool (n = 82), and urine samples (n = 15), which were collected longitudinally from month 1–18 postdelivery. Microbial community composition was characterized by 16S rRNA gene amplicon sequencing of stool samples and was correlated to mycotoxin exposure patterns. Fumonisin B1 (FB1), FB2, and alternariol monomethyl ether (AME) were frequently quantified in stool samples between months 6 and 18. Aflatoxin M1 (AFM1), AME, and citrinin were quantified in breast milk samples at low concentrations. AFM1, FB1, and ochratoxin A were quantified in urine samples at relatively high concentrations. Klebsiella and Escherichia/Shigella were dominant in very early life stool samples (month 1), whereas Bifidobacterium was dominant between months 3 and 6. The total mycotoxin levels in stool were significantly associated with NIs’ gut microbiome composition (PERMANOVA, p < 0.05). However, no significant correlation was observed between specific microbiota and the detection of certain mycotoxins. Albeit a small cohort, this study demonstrates that mycotoxins may influence early life gut microbiome composition.</description><identifier>ISSN: 0013-936X</identifier><identifier>EISSN: 1520-5851</identifier><identifier>DOI: 10.1021/acs.est.3c07786</identifier><identifier>PMID: 38252460</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Aflatoxin M1 ; Aflatoxins ; Biomonitoring ; Breast milk ; Breastfeeding & lactation ; Citrinin ; Community composition ; Composition ; Digestive system ; Ecotoxicology and Public Health ; Exposure ; Fumonisin B1 ; Gastrointestinal tract ; Gene sequencing ; Infants ; Intestinal microflora ; Klebsiella ; Liquid chromatography ; Low concentrations ; Mass spectrometry ; Mass spectroscopy ; Microbiomes ; Microbiota ; Microorganisms ; Mycotoxins ; Neonates ; Ochratoxin A ; rRNA 16S</subject><ispartof>Environmental science & technology, 2024-02, Vol.58 (5), p.2236-2246</ispartof><rights>2024 The Authors. Published by American Chemical Society</rights><rights>Copyright American Chemical Society Feb 6, 2024</rights><rights>2024 The Authors. 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Sci. Technol</addtitle><description>Mycotoxins are toxic chemicals that adversely affect human health. Here, we assessed the influence of mycotoxin exposure on the longitudinal development of early life intestinal microbiota of Nigerian neonates and infants (NIs). Human biomonitoring assays based on liquid chromatography tandem mass spectrometry were applied to quantify mycotoxins in breast milk (n = 68) consumed by the NIs, their stool (n = 82), and urine samples (n = 15), which were collected longitudinally from month 1–18 postdelivery. Microbial community composition was characterized by 16S rRNA gene amplicon sequencing of stool samples and was correlated to mycotoxin exposure patterns. Fumonisin B1 (FB1), FB2, and alternariol monomethyl ether (AME) were frequently quantified in stool samples between months 6 and 18. Aflatoxin M1 (AFM1), AME, and citrinin were quantified in breast milk samples at low concentrations. AFM1, FB1, and ochratoxin A were quantified in urine samples at relatively high concentrations. Klebsiella and Escherichia/Shigella were dominant in very early life stool samples (month 1), whereas Bifidobacterium was dominant between months 3 and 6. The total mycotoxin levels in stool were significantly associated with NIs’ gut microbiome composition (PERMANOVA, p < 0.05). However, no significant correlation was observed between specific microbiota and the detection of certain mycotoxins. Albeit a small cohort, this study demonstrates that mycotoxins may influence early life gut microbiome composition.</description><subject>Aflatoxin M1</subject><subject>Aflatoxins</subject><subject>Biomonitoring</subject><subject>Breast milk</subject><subject>Breastfeeding & lactation</subject><subject>Citrinin</subject><subject>Community composition</subject><subject>Composition</subject><subject>Digestive system</subject><subject>Ecotoxicology and Public Health</subject><subject>Exposure</subject><subject>Fumonisin B1</subject><subject>Gastrointestinal tract</subject><subject>Gene sequencing</subject><subject>Infants</subject><subject>Intestinal microflora</subject><subject>Klebsiella</subject><subject>Liquid chromatography</subject><subject>Low concentrations</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Mycotoxins</subject><subject>Neonates</subject><subject>Ochratoxin A</subject><subject>rRNA 16S</subject><issn>0013-936X</issn><issn>1520-5851</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kc1vEzEQxS0EoqFw5oYscUFCm_prd-0TKqW0kVp6KRI3a-L1pi5ZO7W9qP3v8SppBJV68sG_92bePITeUzKnhNEjMGluU55zQ9pWNi_QjNaMVLWs6Us0I4TySvHm1wF6k9ItIYRxIl-jAy5ZzURDZuj3VxeG4F0O0fkVDj3-5myG-IAvH0zI4d55fHq_CWmMFoPv8HFKwTjItsOLYQMm4-BxvrH4bMz40pkYlsXR4qL74VY2OvB44XvwOb1Fr3pYJ_tu9x6in99Pr0_Oq4urs8XJ8UUFopa5skp1jVDCyM6Sni9tY2rKQckSqoYlkcAIF6pToDiwRgjTG94KaDhXjLaCH6IvW9_NuBxsZ6zPEdZ6E91QgukATv__492NXoU_mpIyQvDJ4dPOIYa7sRxYDy4Zu16Dt2FMmina1mUbMqEfn6C3YYy-5CsU40IIJVmhjrZUuU9K0fb7bSjRU5O6NKkn9a7Jovjwb4g9_1hdAT5vgUm5n_mc3V_2rqpH</recordid><startdate>20240206</startdate><enddate>20240206</enddate><creator>Ayeni, Kolawole I.</creator><creator>Seki, David</creator><creator>Pjevac, Petra</creator><creator>Hausmann, Bela</creator><creator>Krausová, Magdaléna</creator><creator>Braun, Dominik</creator><creator>Wisgrill, Lukas</creator><creator>Berry, David</creator><creator>Warth, Benedikt</creator><creator>Ezekiel, Chibundu N.</creator><general>American Chemical Society</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7ST</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6104-0706</orcidid><orcidid>https://orcid.org/0000-0002-2113-2948</orcidid></search><sort><creationdate>20240206</creationdate><title>Biomonitoring of Dietary Mycotoxin Exposure and Associated Impact on the Gut Microbiome in Nigerian Infants</title><author>Ayeni, Kolawole I. ; Seki, David ; Pjevac, Petra ; Hausmann, Bela ; Krausová, Magdaléna ; Braun, Dominik ; Wisgrill, Lukas ; Berry, David ; Warth, Benedikt ; Ezekiel, Chibundu N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a458t-e99d6494c8de0f3be6c513a988515ab08a20349d9a93a2644cfc374a633921743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aflatoxin M1</topic><topic>Aflatoxins</topic><topic>Biomonitoring</topic><topic>Breast milk</topic><topic>Breastfeeding & lactation</topic><topic>Citrinin</topic><topic>Community composition</topic><topic>Composition</topic><topic>Digestive system</topic><topic>Ecotoxicology and Public Health</topic><topic>Exposure</topic><topic>Fumonisin B1</topic><topic>Gastrointestinal tract</topic><topic>Gene sequencing</topic><topic>Infants</topic><topic>Intestinal microflora</topic><topic>Klebsiella</topic><topic>Liquid chromatography</topic><topic>Low concentrations</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Mycotoxins</topic><topic>Neonates</topic><topic>Ochratoxin A</topic><topic>rRNA 16S</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ayeni, Kolawole I.</creatorcontrib><creatorcontrib>Seki, David</creatorcontrib><creatorcontrib>Pjevac, Petra</creatorcontrib><creatorcontrib>Hausmann, Bela</creatorcontrib><creatorcontrib>Krausová, Magdaléna</creatorcontrib><creatorcontrib>Braun, Dominik</creatorcontrib><creatorcontrib>Wisgrill, Lukas</creatorcontrib><creatorcontrib>Berry, David</creatorcontrib><creatorcontrib>Warth, Benedikt</creatorcontrib><creatorcontrib>Ezekiel, Chibundu N.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental science & technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ayeni, Kolawole I.</au><au>Seki, David</au><au>Pjevac, Petra</au><au>Hausmann, Bela</au><au>Krausová, Magdaléna</au><au>Braun, Dominik</au><au>Wisgrill, Lukas</au><au>Berry, David</au><au>Warth, Benedikt</au><au>Ezekiel, Chibundu N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomonitoring of Dietary Mycotoxin Exposure and Associated Impact on the Gut Microbiome in Nigerian Infants</atitle><jtitle>Environmental science & technology</jtitle><addtitle>Environ. Sci. Technol</addtitle><date>2024-02-06</date><risdate>2024</risdate><volume>58</volume><issue>5</issue><spage>2236</spage><epage>2246</epage><pages>2236-2246</pages><issn>0013-936X</issn><eissn>1520-5851</eissn><abstract>Mycotoxins are toxic chemicals that adversely affect human health. Here, we assessed the influence of mycotoxin exposure on the longitudinal development of early life intestinal microbiota of Nigerian neonates and infants (NIs). Human biomonitoring assays based on liquid chromatography tandem mass spectrometry were applied to quantify mycotoxins in breast milk (n = 68) consumed by the NIs, their stool (n = 82), and urine samples (n = 15), which were collected longitudinally from month 1–18 postdelivery. Microbial community composition was characterized by 16S rRNA gene amplicon sequencing of stool samples and was correlated to mycotoxin exposure patterns. Fumonisin B1 (FB1), FB2, and alternariol monomethyl ether (AME) were frequently quantified in stool samples between months 6 and 18. Aflatoxin M1 (AFM1), AME, and citrinin were quantified in breast milk samples at low concentrations. AFM1, FB1, and ochratoxin A were quantified in urine samples at relatively high concentrations. Klebsiella and Escherichia/Shigella were dominant in very early life stool samples (month 1), whereas Bifidobacterium was dominant between months 3 and 6. The total mycotoxin levels in stool were significantly associated with NIs’ gut microbiome composition (PERMANOVA, p < 0.05). However, no significant correlation was observed between specific microbiota and the detection of certain mycotoxins. Albeit a small cohort, this study demonstrates that mycotoxins may influence early life gut microbiome composition.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>38252460</pmid><doi>10.1021/acs.est.3c07786</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6104-0706</orcidid><orcidid>https://orcid.org/0000-0002-2113-2948</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aflatoxin M1 Aflatoxins Biomonitoring Breast milk Breastfeeding & lactation Citrinin Community composition Composition Digestive system Ecotoxicology and Public Health Exposure Fumonisin B1 Gastrointestinal tract Gene sequencing Infants Intestinal microflora Klebsiella Liquid chromatography Low concentrations Mass spectrometry Mass spectroscopy Microbiomes Microbiota Microorganisms Mycotoxins Neonates Ochratoxin A rRNA 16S |
| title | Biomonitoring of Dietary Mycotoxin Exposure and Associated Impact on the Gut Microbiome in Nigerian Infants |
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