Maternal PM2.5 exposure is associated with preterm birth and gestational diabetes mellitus, and mitochondrial OXPHOS dysfunction in cord blood
Maternal exposure to fine particulate matter (PM 2.5 ) is associated with adverse pregnancy and neonatal health outcomes. To explore the mechanism, we performed mRNA sequencing of neonatal cord blood. From an ongoing prospective cohort, Air Pollution on Pregnancy Outcome (APPO) study, 454 pregnant w...
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| creator | You, Young-Ah Park, Sunwha Kwon, Eunjin Kim, Ye-Ah Hur, Young Min Lee, Ga In Kim, Soo Min Song, Jeong Min Kim, Man S. Kim, Young Ju Kim, Young-Han Na, Sung Hun Park, Mi Hye Bae, Jin-Gon Cho, Geum Joon Lee, Soo-Jeong |
| description | Maternal exposure to fine particulate matter (PM
2.5
) is associated with adverse pregnancy and neonatal health outcomes. To explore the mechanism, we performed mRNA sequencing of neonatal cord blood. From an ongoing prospective cohort, Air Pollution on Pregnancy Outcome (APPO) study, 454 pregnant women from six centers between January 2021 and June 2022 were recruited. Individual PM
2.5
exposure was calculated using a time-weighted average model. In the APPO study, age-matched cord blood samples from the High PM
2.5
(˃15 ug/m
3
;
n
= 10) and Low PM
2.5
(≤ 15 ug/m
3
;
n
= 30) groups were randomly selected for mRNA sequencing. After selecting genes with differential expression in the two groups (
p
-value 1.5), pathway enrichment analysis was performed, and the mitochondrial pathway was analyzed using MitoCarta3.0. The risk of preterm birth (PTB) increased with every 5 µg/m
3
increase of PM
2.5
in the second trimester (odds ratio 1.391,
p
= 0.019) after adjusting for confounding variables. The risk of gestational diabetes mellitus (GDM) increased in the second (odds ratio 1.238,
p
= 0.041) and third trimester (odds ratio 1.290,
p
= 0.029), and entire pregnancy (odds ratio 1.295,
p
= 0.029). The mRNA-sequencing of cord blood showed that genes related to mitochondrial activity (FAM210B, KRT1, FOXO4, TRIM58, and FBXO7) and PTB-related genes (ADIPOR1, YBX1, OPTN, NFkB1, HBG2) were upregulated in the High PM
2.5
group. In addition, exposure to high PM
2.5
affected mitochondrial oxidative phosphorylation (OXPHOS) and proteins in the electron transport chain, a subunit of OXPHOS. These results suggest that exposure to high PM
2.5
during pregnancy may increase the risk of PTB and GDM, and dysregulate PTB-related genes. Alterations in mitochondrial OXPHOS by high PM
2.5
exposure may occur not only in preterm infants but also in normal newborns. Further studies with larger sample sizes are required. |
| doi_str_mv | 10.1007/s11356-023-31774-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10850187</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2923165412</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-8047c12d1a6cce6a91b779076566512931f41c9c95b375c0ac13d4405e0c883a3</originalsourceid><addsrcrecordid>eNqFks1u1TAQhSMEoqXwAiyQJTYsSJnxTxyvUFUBRWp1KwESO8uxfW9dJfHFToC-BM-M01tKYQEr2zrfHHvGp6qeIhwigHyVEZloaqCsZiglr-FetY8N8lpype7f2e9Vj3K-BKCgqHxY7bGWAmCr9qsfZ2byaTQ9OT-jh4L479uY5-RJyMTkHG0ouiPfwnRBtskXdiBdSOVkRkc2Pk9mCnGpd8F0Rc9k8H0fpjm_vEaGMEV7EUeXQoFWn89PVh-Iu8rrebRLJQkjsTE50vUxusfVg7Xps39ysx5Un96--Xh8Up-u3r0_PjqtrYB2qlvg0iJ1aBprfWMUdlIqkI1oGoFUMVxztMoq0TEpLBiLzHEOwoNtW2bYQfV657udu8E768cpmV5vUxhMutLRBP2nMoYLvYlfNUIryuRkcXhx45Dil7nMQQ8h29K6GX2cs2YomFC8adl_UaqQcc5ECwV9_hd6GeflexaKMmwER1oouqNsijknv759OIJeoqF30dAlGvo6Gnqxfna35duSX1koANsBuUjjxqffd__D9idROsUX</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2923165412</pqid></control><display><type>article</type><title>Maternal PM2.5 exposure is associated with preterm birth and gestational diabetes mellitus, and mitochondrial OXPHOS dysfunction in cord blood</title><source>SpringerLink Journals</source><creator>You, Young-Ah ; Park, Sunwha ; Kwon, Eunjin ; Kim, Ye-Ah ; Hur, Young Min ; Lee, Ga In ; Kim, Soo Min ; Song, Jeong Min ; Kim, Man S. ; Kim, Young Ju ; Kim, Young-Han ; Na, Sung Hun ; Park, Mi Hye ; Bae, Jin-Gon ; Cho, Geum Joon ; Lee, Soo-Jeong</creator><creatorcontrib>You, Young-Ah ; Park, Sunwha ; Kwon, Eunjin ; Kim, Ye-Ah ; Hur, Young Min ; Lee, Ga In ; Kim, Soo Min ; Song, Jeong Min ; Kim, Man S. ; Kim, Young Ju ; Kim, Young-Han ; Na, Sung Hun ; Park, Mi Hye ; Bae, Jin-Gon ; Cho, Geum Joon ; Lee, Soo-Jeong ; APPO study group ; The APPO study group</creatorcontrib><description>Maternal exposure to fine particulate matter (PM
2.5
) is associated with adverse pregnancy and neonatal health outcomes. To explore the mechanism, we performed mRNA sequencing of neonatal cord blood. From an ongoing prospective cohort, Air Pollution on Pregnancy Outcome (APPO) study, 454 pregnant women from six centers between January 2021 and June 2022 were recruited. Individual PM
2.5
exposure was calculated using a time-weighted average model. In the APPO study, age-matched cord blood samples from the High PM
2.5
(˃15 ug/m
3
;
n
= 10) and Low PM
2.5
(≤ 15 ug/m
3
;
n
= 30) groups were randomly selected for mRNA sequencing. After selecting genes with differential expression in the two groups (
p
-value < 0.05 and log2 fold change > 1.5), pathway enrichment analysis was performed, and the mitochondrial pathway was analyzed using MitoCarta3.0. The risk of preterm birth (PTB) increased with every 5 µg/m
3
increase of PM
2.5
in the second trimester (odds ratio 1.391,
p
= 0.019) after adjusting for confounding variables. The risk of gestational diabetes mellitus (GDM) increased in the second (odds ratio 1.238,
p
= 0.041) and third trimester (odds ratio 1.290,
p
= 0.029), and entire pregnancy (odds ratio 1.295,
p
= 0.029). The mRNA-sequencing of cord blood showed that genes related to mitochondrial activity (FAM210B, KRT1, FOXO4, TRIM58, and FBXO7) and PTB-related genes (ADIPOR1, YBX1, OPTN, NFkB1, HBG2) were upregulated in the High PM
2.5
group. In addition, exposure to high PM
2.5
affected mitochondrial oxidative phosphorylation (OXPHOS) and proteins in the electron transport chain, a subunit of OXPHOS. These results suggest that exposure to high PM
2.5
during pregnancy may increase the risk of PTB and GDM, and dysregulate PTB-related genes. Alterations in mitochondrial OXPHOS by high PM
2.5
exposure may occur not only in preterm infants but also in normal newborns. Further studies with larger sample sizes are required.</description><identifier>ISSN: 1614-7499</identifier><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-023-31774-0</identifier><identifier>PMID: 38200189</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Air pollution ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Blood ; Cord blood ; Diabetes mellitus ; Earth and Environmental Science ; Ecotoxicology ; Electron transport ; Electron transport chain ; Environment ; Environmental Chemistry ; Environmental Health ; Exposure ; FOXO4 protein ; Gene expression ; gene expression regulation ; Gene sequencing ; Genes ; Gestational diabetes ; maternal exposure ; Mitochondria ; mRNA ; Neonates ; odds ratio ; Oxidative phosphorylation ; Particulate matter ; particulates ; Phosphorylation ; Pregnancy ; Pregnancy complications ; pregnancy outcome ; Premature birth ; Protein transport ; Research Article ; Risk ; time-weighted average ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Environmental science and pollution research international, 2024-02, Vol.31 (7), p.10565-10578</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-8047c12d1a6cce6a91b779076566512931f41c9c95b375c0ac13d4405e0c883a3</citedby><cites>FETCH-LOGICAL-c508t-8047c12d1a6cce6a91b779076566512931f41c9c95b375c0ac13d4405e0c883a3</cites><orcidid>0000-0002-3153-3008</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-023-31774-0$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-023-31774-0$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38200189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>You, Young-Ah</creatorcontrib><creatorcontrib>Park, Sunwha</creatorcontrib><creatorcontrib>Kwon, Eunjin</creatorcontrib><creatorcontrib>Kim, Ye-Ah</creatorcontrib><creatorcontrib>Hur, Young Min</creatorcontrib><creatorcontrib>Lee, Ga In</creatorcontrib><creatorcontrib>Kim, Soo Min</creatorcontrib><creatorcontrib>Song, Jeong Min</creatorcontrib><creatorcontrib>Kim, Man S.</creatorcontrib><creatorcontrib>Kim, Young Ju</creatorcontrib><creatorcontrib>Kim, Young-Han</creatorcontrib><creatorcontrib>Na, Sung Hun</creatorcontrib><creatorcontrib>Park, Mi Hye</creatorcontrib><creatorcontrib>Bae, Jin-Gon</creatorcontrib><creatorcontrib>Cho, Geum Joon</creatorcontrib><creatorcontrib>Lee, Soo-Jeong</creatorcontrib><creatorcontrib>APPO study group</creatorcontrib><creatorcontrib>The APPO study group</creatorcontrib><title>Maternal PM2.5 exposure is associated with preterm birth and gestational diabetes mellitus, and mitochondrial OXPHOS dysfunction in cord blood</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Maternal exposure to fine particulate matter (PM
2.5
) is associated with adverse pregnancy and neonatal health outcomes. To explore the mechanism, we performed mRNA sequencing of neonatal cord blood. From an ongoing prospective cohort, Air Pollution on Pregnancy Outcome (APPO) study, 454 pregnant women from six centers between January 2021 and June 2022 were recruited. Individual PM
2.5
exposure was calculated using a time-weighted average model. In the APPO study, age-matched cord blood samples from the High PM
2.5
(˃15 ug/m
3
;
n
= 10) and Low PM
2.5
(≤ 15 ug/m
3
;
n
= 30) groups were randomly selected for mRNA sequencing. After selecting genes with differential expression in the two groups (
p
-value < 0.05 and log2 fold change > 1.5), pathway enrichment analysis was performed, and the mitochondrial pathway was analyzed using MitoCarta3.0. The risk of preterm birth (PTB) increased with every 5 µg/m
3
increase of PM
2.5
in the second trimester (odds ratio 1.391,
p
= 0.019) after adjusting for confounding variables. The risk of gestational diabetes mellitus (GDM) increased in the second (odds ratio 1.238,
p
= 0.041) and third trimester (odds ratio 1.290,
p
= 0.029), and entire pregnancy (odds ratio 1.295,
p
= 0.029). The mRNA-sequencing of cord blood showed that genes related to mitochondrial activity (FAM210B, KRT1, FOXO4, TRIM58, and FBXO7) and PTB-related genes (ADIPOR1, YBX1, OPTN, NFkB1, HBG2) were upregulated in the High PM
2.5
group. In addition, exposure to high PM
2.5
affected mitochondrial oxidative phosphorylation (OXPHOS) and proteins in the electron transport chain, a subunit of OXPHOS. These results suggest that exposure to high PM
2.5
during pregnancy may increase the risk of PTB and GDM, and dysregulate PTB-related genes. Alterations in mitochondrial OXPHOS by high PM
2.5
exposure may occur not only in preterm infants but also in normal newborns. Further studies with larger sample sizes are required.</description><subject>Air pollution</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Blood</subject><subject>Cord blood</subject><subject>Diabetes mellitus</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Electron transport</subject><subject>Electron transport chain</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Exposure</subject><subject>FOXO4 protein</subject><subject>Gene expression</subject><subject>gene expression regulation</subject><subject>Gene sequencing</subject><subject>Genes</subject><subject>Gestational diabetes</subject><subject>maternal exposure</subject><subject>Mitochondria</subject><subject>mRNA</subject><subject>Neonates</subject><subject>odds ratio</subject><subject>Oxidative phosphorylation</subject><subject>Particulate matter</subject><subject>particulates</subject><subject>Phosphorylation</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>pregnancy outcome</subject><subject>Premature birth</subject><subject>Protein transport</subject><subject>Research Article</subject><subject>Risk</subject><subject>time-weighted average</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><issn>1614-7499</issn><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNqFks1u1TAQhSMEoqXwAiyQJTYsSJnxTxyvUFUBRWp1KwESO8uxfW9dJfHFToC-BM-M01tKYQEr2zrfHHvGp6qeIhwigHyVEZloaqCsZiglr-FetY8N8lpype7f2e9Vj3K-BKCgqHxY7bGWAmCr9qsfZ2byaTQ9OT-jh4L479uY5-RJyMTkHG0ouiPfwnRBtskXdiBdSOVkRkc2Pk9mCnGpd8F0Rc9k8H0fpjm_vEaGMEV7EUeXQoFWn89PVh-Iu8rrebRLJQkjsTE50vUxusfVg7Xps39ysx5Un96--Xh8Up-u3r0_PjqtrYB2qlvg0iJ1aBprfWMUdlIqkI1oGoFUMVxztMoq0TEpLBiLzHEOwoNtW2bYQfV657udu8E768cpmV5vUxhMutLRBP2nMoYLvYlfNUIryuRkcXhx45Dil7nMQQ8h29K6GX2cs2YomFC8adl_UaqQcc5ECwV9_hd6GeflexaKMmwER1oouqNsijknv759OIJeoqF30dAlGvo6Gnqxfna35duSX1koANsBuUjjxqffd__D9idROsUX</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>You, Young-Ah</creator><creator>Park, Sunwha</creator><creator>Kwon, Eunjin</creator><creator>Kim, Ye-Ah</creator><creator>Hur, Young Min</creator><creator>Lee, Ga In</creator><creator>Kim, Soo Min</creator><creator>Song, Jeong Min</creator><creator>Kim, Man S.</creator><creator>Kim, Young Ju</creator><creator>Kim, Young-Han</creator><creator>Na, Sung Hun</creator><creator>Park, Mi Hye</creator><creator>Bae, Jin-Gon</creator><creator>Cho, Geum Joon</creator><creator>Lee, Soo-Jeong</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7SN</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3153-3008</orcidid></search><sort><creationdate>20240201</creationdate><title>Maternal PM2.5 exposure is associated with preterm birth and gestational diabetes mellitus, and mitochondrial OXPHOS dysfunction in cord blood</title><author>You, Young-Ah ; Park, Sunwha ; Kwon, Eunjin ; Kim, Ye-Ah ; Hur, Young Min ; Lee, Ga In ; Kim, Soo Min ; Song, Jeong Min ; Kim, Man S. ; Kim, Young Ju ; Kim, Young-Han ; Na, Sung Hun ; Park, Mi Hye ; Bae, Jin-Gon ; Cho, Geum Joon ; Lee, Soo-Jeong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-8047c12d1a6cce6a91b779076566512931f41c9c95b375c0ac13d4405e0c883a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Air pollution</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Blood</topic><topic>Cord blood</topic><topic>Diabetes mellitus</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Electron transport</topic><topic>Electron transport chain</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Exposure</topic><topic>FOXO4 protein</topic><topic>Gene expression</topic><topic>gene expression regulation</topic><topic>Gene sequencing</topic><topic>Genes</topic><topic>Gestational diabetes</topic><topic>maternal exposure</topic><topic>Mitochondria</topic><topic>mRNA</topic><topic>Neonates</topic><topic>odds ratio</topic><topic>Oxidative phosphorylation</topic><topic>Particulate matter</topic><topic>particulates</topic><topic>Phosphorylation</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>pregnancy outcome</topic><topic>Premature birth</topic><topic>Protein transport</topic><topic>Research Article</topic><topic>Risk</topic><topic>time-weighted average</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollution Control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>You, Young-Ah</creatorcontrib><creatorcontrib>Park, Sunwha</creatorcontrib><creatorcontrib>Kwon, Eunjin</creatorcontrib><creatorcontrib>Kim, Ye-Ah</creatorcontrib><creatorcontrib>Hur, Young Min</creatorcontrib><creatorcontrib>Lee, Ga In</creatorcontrib><creatorcontrib>Kim, Soo Min</creatorcontrib><creatorcontrib>Song, Jeong Min</creatorcontrib><creatorcontrib>Kim, Man S.</creatorcontrib><creatorcontrib>Kim, Young Ju</creatorcontrib><creatorcontrib>Kim, Young-Han</creatorcontrib><creatorcontrib>Na, Sung Hun</creatorcontrib><creatorcontrib>Park, Mi Hye</creatorcontrib><creatorcontrib>Bae, Jin-Gon</creatorcontrib><creatorcontrib>Cho, Geum Joon</creatorcontrib><creatorcontrib>Lee, Soo-Jeong</creatorcontrib><creatorcontrib>APPO study group</creatorcontrib><creatorcontrib>The APPO study group</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ecology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>You, Young-Ah</au><au>Park, Sunwha</au><au>Kwon, Eunjin</au><au>Kim, Ye-Ah</au><au>Hur, Young Min</au><au>Lee, Ga In</au><au>Kim, Soo Min</au><au>Song, Jeong Min</au><au>Kim, Man S.</au><au>Kim, Young Ju</au><au>Kim, Young-Han</au><au>Na, Sung Hun</au><au>Park, Mi Hye</au><au>Bae, Jin-Gon</au><au>Cho, Geum Joon</au><au>Lee, Soo-Jeong</au><aucorp>APPO study group</aucorp><aucorp>The APPO study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal PM2.5 exposure is associated with preterm birth and gestational diabetes mellitus, and mitochondrial OXPHOS dysfunction in cord blood</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>31</volume><issue>7</issue><spage>10565</spage><epage>10578</epage><pages>10565-10578</pages><issn>1614-7499</issn><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Maternal exposure to fine particulate matter (PM
2.5
) is associated with adverse pregnancy and neonatal health outcomes. To explore the mechanism, we performed mRNA sequencing of neonatal cord blood. From an ongoing prospective cohort, Air Pollution on Pregnancy Outcome (APPO) study, 454 pregnant women from six centers between January 2021 and June 2022 were recruited. Individual PM
2.5
exposure was calculated using a time-weighted average model. In the APPO study, age-matched cord blood samples from the High PM
2.5
(˃15 ug/m
3
;
n
= 10) and Low PM
2.5
(≤ 15 ug/m
3
;
n
= 30) groups were randomly selected for mRNA sequencing. After selecting genes with differential expression in the two groups (
p
-value < 0.05 and log2 fold change > 1.5), pathway enrichment analysis was performed, and the mitochondrial pathway was analyzed using MitoCarta3.0. The risk of preterm birth (PTB) increased with every 5 µg/m
3
increase of PM
2.5
in the second trimester (odds ratio 1.391,
p
= 0.019) after adjusting for confounding variables. The risk of gestational diabetes mellitus (GDM) increased in the second (odds ratio 1.238,
p
= 0.041) and third trimester (odds ratio 1.290,
p
= 0.029), and entire pregnancy (odds ratio 1.295,
p
= 0.029). The mRNA-sequencing of cord blood showed that genes related to mitochondrial activity (FAM210B, KRT1, FOXO4, TRIM58, and FBXO7) and PTB-related genes (ADIPOR1, YBX1, OPTN, NFkB1, HBG2) were upregulated in the High PM
2.5
group. In addition, exposure to high PM
2.5
affected mitochondrial oxidative phosphorylation (OXPHOS) and proteins in the electron transport chain, a subunit of OXPHOS. These results suggest that exposure to high PM
2.5
during pregnancy may increase the risk of PTB and GDM, and dysregulate PTB-related genes. Alterations in mitochondrial OXPHOS by high PM
2.5
exposure may occur not only in preterm infants but also in normal newborns. Further studies with larger sample sizes are required.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38200189</pmid><doi>10.1007/s11356-023-31774-0</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-3153-3008</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1614-7499 |
| ispartof | Environmental science and pollution research international, 2024-02, Vol.31 (7), p.10565-10578 |
| issn | 1614-7499 0944-1344 1614-7499 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10850187 |
| source | SpringerLink Journals |
| subjects | Air pollution Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Blood Cord blood Diabetes mellitus Earth and Environmental Science Ecotoxicology Electron transport Electron transport chain Environment Environmental Chemistry Environmental Health Exposure FOXO4 protein Gene expression gene expression regulation Gene sequencing Genes Gestational diabetes maternal exposure Mitochondria mRNA Neonates odds ratio Oxidative phosphorylation Particulate matter particulates Phosphorylation Pregnancy Pregnancy complications pregnancy outcome Premature birth Protein transport Research Article Risk time-weighted average Waste Water Technology Water Management Water Pollution Control |
| title | Maternal PM2.5 exposure is associated with preterm birth and gestational diabetes mellitus, and mitochondrial OXPHOS dysfunction in cord blood |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T05%3A11%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Maternal%20PM2.5%20exposure%20is%20associated%20with%20preterm%20birth%20and%20gestational%20diabetes%20mellitus,%20and%20mitochondrial%20OXPHOS%20dysfunction%20in%20cord%20blood&rft.jtitle=Environmental%20science%20and%20pollution%20research%20international&rft.au=You,%20Young-Ah&rft.aucorp=APPO%20study%20group&rft.date=2024-02-01&rft.volume=31&rft.issue=7&rft.spage=10565&rft.epage=10578&rft.pages=10565-10578&rft.issn=1614-7499&rft.eissn=1614-7499&rft_id=info:doi/10.1007/s11356-023-31774-0&rft_dat=%3Cproquest_pubme%3E2923165412%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2923165412&rft_id=info:pmid/38200189&rfr_iscdi=true |