Hepatocellular carcinoma with lung metastasis showing hemochromatosis in an Egyptian fruit bat (Rousettus aegyptiacus)
After an Egyptian fruit bat (Rousettus aegyptiacus) in a zoo became emaciated and died, a necropsy revealed multiple nodules on the liver and lung surfaces. Microscopy revealed that the liver nodules consisted of neoplastic hepatocytes and showed metastasis in the lung lobes. Most of the neoplastic...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2024, Vol.86(1), pp.49-53 |
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| creator | KAWAGUCHI, Nijiho FUKE, Naoyuki NUEANGPHUET, Phawut PORNTHUMMAWAT, Apisit NIAZI, Ahmad Massoud IZZATI, Uda Zahli HIRAI, Takuya YAMAGUCHI, Ryoji |
| description | After an Egyptian fruit bat (Rousettus aegyptiacus) in a zoo became emaciated and died, a necropsy revealed multiple nodules on the liver and lung surfaces. Microscopy revealed that the liver nodules consisted of neoplastic hepatocytes and showed metastasis in the lung lobes. Most of the neoplastic cells in the liver and lung showed positive labeling for HepPar-1, cytokeratin 19, glypican-3, and Ki-67. Hepatocellular degeneration and necrosis were diffuse in the liver parenchyma. Berlin blue staining revealed large amounts of iron in normal and neoplastic cells. Based on these pieces of evidence, this case was diagnosed as hepatocellular carcinoma with hemochromatosis. This is believed to be the first report of hepatocellular carcinoma in an Egyptian fruit bat that has been immunophenotypically examined in detail by pathological examination. |
| doi_str_mv | 10.1292/jvms.23-0152 |
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Microscopy revealed that the liver nodules consisted of neoplastic hepatocytes and showed metastasis in the lung lobes. Most of the neoplastic cells in the liver and lung showed positive labeling for HepPar-1, cytokeratin 19, glypican-3, and Ki-67. Hepatocellular degeneration and necrosis were diffuse in the liver parenchyma. Berlin blue staining revealed large amounts of iron in normal and neoplastic cells. Based on these pieces of evidence, this case was diagnosed as hepatocellular carcinoma with hemochromatosis. This is believed to be the first report of hepatocellular carcinoma in an Egyptian fruit bat that has been immunophenotypically examined in detail by pathological examination.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.23-0152</identifier><identifier>PMID: 37940547</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>Animals ; Carcinoma, Hepatocellular - veterinary ; Chiroptera ; Cytokeratin ; Egyptian fruit bat ; Fruits ; Hemochromatosis ; Hemochromatosis - veterinary ; Heparan sulfate proteoglycans ; Hepatocellular carcinoma ; Hepatocytes ; Liver ; Liver Neoplasms - veterinary ; Lung carcinoma ; lung metastasis ; Lung Neoplasms - veterinary ; Metastases ; Necropsy ; Nodules ; Parenchyma ; Pathology ; Rousettus aegyptiacus</subject><ispartof>Journal of Veterinary Medical Science, 2024, Vol.86(1), pp.49-53</ispartof><rights>2024 by the Japanese Society of Veterinary Science</rights><rights>2024. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). 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Vet. Med. Sci.</addtitle><description>After an Egyptian fruit bat (Rousettus aegyptiacus) in a zoo became emaciated and died, a necropsy revealed multiple nodules on the liver and lung surfaces. Microscopy revealed that the liver nodules consisted of neoplastic hepatocytes and showed metastasis in the lung lobes. Most of the neoplastic cells in the liver and lung showed positive labeling for HepPar-1, cytokeratin 19, glypican-3, and Ki-67. Hepatocellular degeneration and necrosis were diffuse in the liver parenchyma. Berlin blue staining revealed large amounts of iron in normal and neoplastic cells. Based on these pieces of evidence, this case was diagnosed as hepatocellular carcinoma with hemochromatosis. This is believed to be the first report of hepatocellular carcinoma in an Egyptian fruit bat that has been immunophenotypically examined in detail by pathological examination.</description><subject>Animals</subject><subject>Carcinoma, Hepatocellular - veterinary</subject><subject>Chiroptera</subject><subject>Cytokeratin</subject><subject>Egyptian fruit bat</subject><subject>Fruits</subject><subject>Hemochromatosis</subject><subject>Hemochromatosis - veterinary</subject><subject>Heparan sulfate proteoglycans</subject><subject>Hepatocellular carcinoma</subject><subject>Hepatocytes</subject><subject>Liver</subject><subject>Liver Neoplasms - veterinary</subject><subject>Lung carcinoma</subject><subject>lung metastasis</subject><subject>Lung Neoplasms - veterinary</subject><subject>Metastases</subject><subject>Necropsy</subject><subject>Nodules</subject><subject>Parenchyma</subject><subject>Pathology</subject><subject>Rousettus aegyptiacus</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV1rFDEYhYModlu981oC3lRwaj5m8nFVtLRWKAii1-HdbGYny8xkTTJb-u_NMOuiQkjCex4OOTkIvaHkijLNPu4OQ7pivCK0Yc_QivJaVrLm-jlaEU1FJVlDztB5SjtCGK2FfonOuNQ1aWq5Qod7t4ccrOv7qYeILUTrxzAAfvS5w_00bvHgMqSyfMKpC4--jDo3BNvFwuUwz_2IYcS326d99uXSxslnvIaML7-HKbmcp4TBLbKd0vtX6EULfXKvj-cF-nl3--Pmvnr49uXrzaeHyjZU58pSoahcU0k2wtVtQxvQsLFtzYTQAKJdW8lZ2zRArOJSUSrq1gm2AaeoBsov0PXiu5_Wg9tYN-YIvdlHP0B8MgG8-VcZfWe24WAoUbVWjSwOl0eHGH5NLmUz-DR_F4yuRDNMKUW4IGpG3_2H7sIUx5LPlKIEV4TJmfqwUDaGlKJrT6-hxMyNmrlRw7iZGy34278TnOA_FRbg8wLsSkdbdwIgZm97t7gpYei8HV1Pou0gGjfy3zSlt-w</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>KAWAGUCHI, Nijiho</creator><creator>FUKE, Naoyuki</creator><creator>NUEANGPHUET, Phawut</creator><creator>PORNTHUMMAWAT, Apisit</creator><creator>NIAZI, Ahmad Massoud</creator><creator>IZZATI, Uda Zahli</creator><creator>HIRAI, Takuya</creator><creator>YAMAGUCHI, Ryoji</creator><general>JAPANESE SOCIETY OF VETERINARY SCIENCE</general><general>Japan Science and Technology Agency</general><general>The Japanese Society of Veterinary Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240101</creationdate><title>Hepatocellular carcinoma with lung metastasis showing hemochromatosis in an Egyptian fruit bat (Rousettus aegyptiacus)</title><author>KAWAGUCHI, Nijiho ; FUKE, Naoyuki ; NUEANGPHUET, Phawut ; PORNTHUMMAWAT, Apisit ; NIAZI, Ahmad Massoud ; IZZATI, Uda Zahli ; HIRAI, Takuya ; YAMAGUCHI, Ryoji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-c16817b170d6e4f515a9adcf42669aa6fbc732f55a0c83781164fe62dae819a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Carcinoma, Hepatocellular - veterinary</topic><topic>Chiroptera</topic><topic>Cytokeratin</topic><topic>Egyptian fruit bat</topic><topic>Fruits</topic><topic>Hemochromatosis</topic><topic>Hemochromatosis - veterinary</topic><topic>Heparan sulfate proteoglycans</topic><topic>Hepatocellular carcinoma</topic><topic>Hepatocytes</topic><topic>Liver</topic><topic>Liver Neoplasms - veterinary</topic><topic>Lung carcinoma</topic><topic>lung metastasis</topic><topic>Lung Neoplasms - veterinary</topic><topic>Metastases</topic><topic>Necropsy</topic><topic>Nodules</topic><topic>Parenchyma</topic><topic>Pathology</topic><topic>Rousettus aegyptiacus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAWAGUCHI, Nijiho</creatorcontrib><creatorcontrib>FUKE, Naoyuki</creatorcontrib><creatorcontrib>NUEANGPHUET, Phawut</creatorcontrib><creatorcontrib>PORNTHUMMAWAT, Apisit</creatorcontrib><creatorcontrib>NIAZI, Ahmad Massoud</creatorcontrib><creatorcontrib>IZZATI, Uda Zahli</creatorcontrib><creatorcontrib>HIRAI, Takuya</creatorcontrib><creatorcontrib>YAMAGUCHI, Ryoji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAWAGUCHI, Nijiho</au><au>FUKE, Naoyuki</au><au>NUEANGPHUET, Phawut</au><au>PORNTHUMMAWAT, Apisit</au><au>NIAZI, Ahmad Massoud</au><au>IZZATI, Uda Zahli</au><au>HIRAI, Takuya</au><au>YAMAGUCHI, Ryoji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatocellular carcinoma with lung metastasis showing hemochromatosis in an Egyptian fruit bat (Rousettus aegyptiacus)</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>86</volume><issue>1</issue><spage>49</spage><epage>53</epage><pages>49-53</pages><artnum>23-0152</artnum><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>After an Egyptian fruit bat (Rousettus aegyptiacus) in a zoo became emaciated and died, a necropsy revealed multiple nodules on the liver and lung surfaces. Microscopy revealed that the liver nodules consisted of neoplastic hepatocytes and showed metastasis in the lung lobes. Most of the neoplastic cells in the liver and lung showed positive labeling for HepPar-1, cytokeratin 19, glypican-3, and Ki-67. Hepatocellular degeneration and necrosis were diffuse in the liver parenchyma. Berlin blue staining revealed large amounts of iron in normal and neoplastic cells. Based on these pieces of evidence, this case was diagnosed as hepatocellular carcinoma with hemochromatosis. 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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Animals Carcinoma, Hepatocellular - veterinary Chiroptera Cytokeratin Egyptian fruit bat Fruits Hemochromatosis Hemochromatosis - veterinary Heparan sulfate proteoglycans Hepatocellular carcinoma Hepatocytes Liver Liver Neoplasms - veterinary Lung carcinoma lung metastasis Lung Neoplasms - veterinary Metastases Necropsy Nodules Parenchyma Pathology Rousettus aegyptiacus |
| title | Hepatocellular carcinoma with lung metastasis showing hemochromatosis in an Egyptian fruit bat (Rousettus aegyptiacus) |
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