Targeting the AKT‐P53/CREB pathway with epicatechin for improved prognosis of traumatic brain injury

Aims The aim of this study was to evaluate the effect of epicatechin, on neurological recovery and neuroinflammation after traumatic brain injury (TBI) to investigate its potential value in clinical practice. Methods TBI model was established in adult rats by CCI method. The effect of epicatechin wa...

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Veröffentlicht in:	CNS neuroscience & therapeutics 2024-02, Vol.30 (2), p.e14364-n/a
Hauptverfasser:	Wang, Ziheng, Lu, Zhichao, Chen, Yixun, Wang, Chenxing, Gong, Peipei, Jiang, Rui, Liu, Qianqian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesives AKT protein Alzheimer's disease Anti-inflammatory agents Antibodies Antigens Biotechnology industry Brain Chemokines Cocoa Cyclic AMP response element-binding protein Cytokines Enzyme-linked immunosorbent assay Epicatechin Gene expression Hydraulics Immunofluorescence Inflammation Injuries International economic relations Kinases microglia neurological function Neurons Original p53 Protein Polymerase chain reaction Polyphenols Proteins Traumatic brain injury Tumor necrosis factor-TNF
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