Interplay between stochastic enzyme activity and microtubule stability drives detyrosination enrichment on microtubule subsets

Microtubules in cells consist of functionally diverse subpopulations carrying distinct post-translational modifications (PTMs). Akin to the histone code, the tubulin code regulates a myriad of microtubule functions, ranging from intracellular transport to chromosome segregation. However, how individ...

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Veröffentlicht in:	Current biology 2023-12, Vol.33 (23), p.5169-5184.e8
Hauptverfasser:	Tang, Qing, Sensale, Sebastian, Bond, Charles, Xing, Jiazheng, Qiao, Andy, Hugelier, Siewert, Arab, Arian, Arya, Gaurav, Lakadamyali, Melike
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line detyrosination microtubule dynamics Microtubule-Associated Proteins - metabolism microtubules Microtubules - metabolism post-translational modifications Protein Processing, Post-Translational single-molecule tracking super-resolution Tubulin - metabolism Tyrosine - metabolism VASH
Online-Zugang:	Volltext
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