Polybrominated biphenyls (PBBs) and prevalence of autoimmune disorders among members of the Michigan PBB registry
Polybrominated biphenyls (PBBs), a class of endocrine disrupting chemicals, were the main chemicals present in one of the largest industrial accidents in the United States. We investigated the association between serum PBB-153 levels and autoimmune disorders among members of the Michigan PBB Registr...
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| Veröffentlicht in: | Environmental research 2023-12, Vol.239 (Pt 1), p.117312-117312, Article 117312 |
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| creator | Hood, Robert B. Terrell, Metrecia L. Mardovich, Sarah Somers, Emily C. Pearson, Melanie Barton, Hillary Tomlinson, Martha Scott Marder, M. Elizabeth Barr, Dana Boyd Marcus, Michele |
| description | Polybrominated biphenyls (PBBs), a class of endocrine disrupting chemicals, were the main chemicals present in one of the largest industrial accidents in the United States. We investigated the association between serum PBB-153 levels and autoimmune disorders among members of the Michigan PBB Registry.
Eight hundred and ninety-five members of the registry had both a serum PBB-153 measurement and had completed one or more questionnaires about autoimmune disorders. Autoimmune disorders were examined collectively and within specific organ systems. Sex-stratified unadjusted and adjusted log-binomial models were used to examine the association between tertiles of serum PBB-153 levels and autoimmune disorders. Models were adjusted by lifestage at exposure (in utero, childhood, adulthood), smoking history (never, past, current), and total serum lipid levels (continuous). We utilized cubic spline models to investigate non-linearity between serum PBB-153 levels and the prevalence of autoimmune disorders.
Approximately 12.9% and 20.7% of male and female participants reported having one or more autoimmune disorders, respectively. After adjustment for potential confounders, we observed no association between PBB-153 tertiles and the composite classification of ‘any autoimmune disorder’ in either sex. We observed some evidence for an association between serum PBB-153 levels and rheumatoid arthritis in males and females; however, this was not statistically significant in females. We also observed some evidence for an association between serum PBB-153 levels and neurological- and thyroid-related autoimmune disorders in females, but again this was not statistically significant. Additionally, we identified dose-response curves for serum PBB-153 levels and the prevalence of autoimmune disorders that differed by lifestage of exposure and sex.
We observed some evidence that increasing serum PBB-153 levels were associated with three specified autoimmune disorders. Studies focusing on these three autoimmune disorders and the potential non-linear trend differences by lifestage of exposure warrant further investigation.
•Serum PBB-153 levels were not associated with the prevalence of autoimmune disorders as a composite outcome.•Serum PBB-153 levels may be associated with rheumatoid arthritis in males and females.•Serum PBB-153 levels may be associated with neurological and thyroid autoimmune disorders in females.•The dose-response curve between serum PBB-153 levels and autoimmune |
| doi_str_mv | 10.1016/j.envres.2023.117312 |
| format | Article |
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Eight hundred and ninety-five members of the registry had both a serum PBB-153 measurement and had completed one or more questionnaires about autoimmune disorders. Autoimmune disorders were examined collectively and within specific organ systems. Sex-stratified unadjusted and adjusted log-binomial models were used to examine the association between tertiles of serum PBB-153 levels and autoimmune disorders. Models were adjusted by lifestage at exposure (in utero, childhood, adulthood), smoking history (never, past, current), and total serum lipid levels (continuous). We utilized cubic spline models to investigate non-linearity between serum PBB-153 levels and the prevalence of autoimmune disorders.
Approximately 12.9% and 20.7% of male and female participants reported having one or more autoimmune disorders, respectively. After adjustment for potential confounders, we observed no association between PBB-153 tertiles and the composite classification of ‘any autoimmune disorder’ in either sex. We observed some evidence for an association between serum PBB-153 levels and rheumatoid arthritis in males and females; however, this was not statistically significant in females. We also observed some evidence for an association between serum PBB-153 levels and neurological- and thyroid-related autoimmune disorders in females, but again this was not statistically significant. Additionally, we identified dose-response curves for serum PBB-153 levels and the prevalence of autoimmune disorders that differed by lifestage of exposure and sex.
We observed some evidence that increasing serum PBB-153 levels were associated with three specified autoimmune disorders. Studies focusing on these three autoimmune disorders and the potential non-linear trend differences by lifestage of exposure warrant further investigation.
•Serum PBB-153 levels were not associated with the prevalence of autoimmune disorders as a composite outcome.•Serum PBB-153 levels may be associated with rheumatoid arthritis in males and females.•Serum PBB-153 levels may be associated with neurological and thyroid autoimmune disorders in females.•The dose-response curve between serum PBB-153 levels and autoimmune disorders may differ by lifestage exposure window.</description><identifier>ISSN: 0013-9351</identifier><identifier>ISSN: 1096-0953</identifier><identifier>EISSN: 1096-0953</identifier><identifier>DOI: 10.1016/j.envres.2023.117312</identifier><identifier>PMID: 37806482</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adult ; Autoimmune Diseases - chemically induced ; Autoimmune Diseases - epidemiology ; Autoimmune disorders ; Child ; Female ; Humans ; Male ; Michigan ; Michigan - epidemiology ; Polybrominated Biphenyls ; Prevalence ; Registries ; Rheumatoid arthritis ; Thyroid autoimmune disorders</subject><ispartof>Environmental research, 2023-12, Vol.239 (Pt 1), p.117312-117312, Article 117312</ispartof><rights>2023 Elsevier Inc.</rights><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c367t-bc8cab21b24a84612004440663b4c9848c16de7bb55457f5b2a989ee66edd7eb3</cites><orcidid>0000-0002-2052-1685 ; 0000-0002-9068-9280 ; 0000-0003-3909-7084 ; 0000-0001-9406-2226 ; 0000-0001-9902-9206 ; 0000-0001-5234-3978</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.envres.2023.117312$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37806482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hood, Robert B.</creatorcontrib><creatorcontrib>Terrell, Metrecia L.</creatorcontrib><creatorcontrib>Mardovich, Sarah</creatorcontrib><creatorcontrib>Somers, Emily C.</creatorcontrib><creatorcontrib>Pearson, Melanie</creatorcontrib><creatorcontrib>Barton, Hillary</creatorcontrib><creatorcontrib>Tomlinson, Martha Scott</creatorcontrib><creatorcontrib>Marder, M. Elizabeth</creatorcontrib><creatorcontrib>Barr, Dana Boyd</creatorcontrib><creatorcontrib>Marcus, Michele</creatorcontrib><title>Polybrominated biphenyls (PBBs) and prevalence of autoimmune disorders among members of the Michigan PBB registry</title><title>Environmental research</title><addtitle>Environ Res</addtitle><description>Polybrominated biphenyls (PBBs), a class of endocrine disrupting chemicals, were the main chemicals present in one of the largest industrial accidents in the United States. We investigated the association between serum PBB-153 levels and autoimmune disorders among members of the Michigan PBB Registry.
Eight hundred and ninety-five members of the registry had both a serum PBB-153 measurement and had completed one or more questionnaires about autoimmune disorders. Autoimmune disorders were examined collectively and within specific organ systems. Sex-stratified unadjusted and adjusted log-binomial models were used to examine the association between tertiles of serum PBB-153 levels and autoimmune disorders. Models were adjusted by lifestage at exposure (in utero, childhood, adulthood), smoking history (never, past, current), and total serum lipid levels (continuous). We utilized cubic spline models to investigate non-linearity between serum PBB-153 levels and the prevalence of autoimmune disorders.
Approximately 12.9% and 20.7% of male and female participants reported having one or more autoimmune disorders, respectively. After adjustment for potential confounders, we observed no association between PBB-153 tertiles and the composite classification of ‘any autoimmune disorder’ in either sex. We observed some evidence for an association between serum PBB-153 levels and rheumatoid arthritis in males and females; however, this was not statistically significant in females. We also observed some evidence for an association between serum PBB-153 levels and neurological- and thyroid-related autoimmune disorders in females, but again this was not statistically significant. Additionally, we identified dose-response curves for serum PBB-153 levels and the prevalence of autoimmune disorders that differed by lifestage of exposure and sex.
We observed some evidence that increasing serum PBB-153 levels were associated with three specified autoimmune disorders. Studies focusing on these three autoimmune disorders and the potential non-linear trend differences by lifestage of exposure warrant further investigation.
•Serum PBB-153 levels were not associated with the prevalence of autoimmune disorders as a composite outcome.•Serum PBB-153 levels may be associated with rheumatoid arthritis in males and females.•Serum PBB-153 levels may be associated with neurological and thyroid autoimmune disorders in females.•The dose-response curve between serum PBB-153 levels and autoimmune disorders may differ by lifestage exposure window.</description><subject>Adult</subject><subject>Autoimmune Diseases - chemically induced</subject><subject>Autoimmune Diseases - epidemiology</subject><subject>Autoimmune disorders</subject><subject>Child</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Michigan</subject><subject>Michigan - epidemiology</subject><subject>Polybrominated Biphenyls</subject><subject>Prevalence</subject><subject>Registries</subject><subject>Rheumatoid arthritis</subject><subject>Thyroid autoimmune disorders</subject><issn>0013-9351</issn><issn>1096-0953</issn><issn>1096-0953</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1vEzEQhi0EoqHwDxDysRw2-Gu93guIVnxJRfQAZ8sfk8TR2k7t3Uj592y0pYILp9FonnnH8oPQa0rWlFD5br-GdCxQ14wwvqa045Q9QStKetmQvuVP0YoQypuet_QCvah1P7e05eQ5uuCdIlIotkL3d3k42ZJjSGYEj2047CCdhoqv7q6v61tskseHAkczQHKA8wabacwhxikB9qHm4qFUbGJOWxwh2nM3U-MO8PfgdmFrEp6jcIFtqGM5vUTPNmao8OqhXqJfnz_9vPna3P748u3m423juOzGxjrljGXUMmGUkJQRIoQgUnIrXK-EclR66KxtW9F2m9Yy06seQErwvgPLL9GHJfcw2QjeQRqLGfShhGjKSWcT9L-TFHZ6m4-aEiU4YWpOuHpIKPl-gjrqGKqDYTAJ8lQ1U51QvGNEzqhYUFdyrQU2j3co0Wddeq8XXfqsSy-65rU3f7_xcemPnxl4vwAw_9QxQNHVhbMIHwq4Ufsc_n_hN9CJqm8</recordid><startdate>20231215</startdate><enddate>20231215</enddate><creator>Hood, Robert B.</creator><creator>Terrell, Metrecia L.</creator><creator>Mardovich, Sarah</creator><creator>Somers, Emily C.</creator><creator>Pearson, Melanie</creator><creator>Barton, Hillary</creator><creator>Tomlinson, Martha Scott</creator><creator>Marder, M. Elizabeth</creator><creator>Barr, Dana Boyd</creator><creator>Marcus, Michele</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2052-1685</orcidid><orcidid>https://orcid.org/0000-0002-9068-9280</orcidid><orcidid>https://orcid.org/0000-0003-3909-7084</orcidid><orcidid>https://orcid.org/0000-0001-9406-2226</orcidid><orcidid>https://orcid.org/0000-0001-9902-9206</orcidid><orcidid>https://orcid.org/0000-0001-5234-3978</orcidid></search><sort><creationdate>20231215</creationdate><title>Polybrominated biphenyls (PBBs) and prevalence of autoimmune disorders among members of the Michigan PBB registry</title><author>Hood, Robert B. ; Terrell, Metrecia L. ; Mardovich, Sarah ; Somers, Emily C. ; Pearson, Melanie ; Barton, Hillary ; Tomlinson, Martha Scott ; Marder, M. Elizabeth ; Barr, Dana Boyd ; Marcus, Michele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-bc8cab21b24a84612004440663b4c9848c16de7bb55457f5b2a989ee66edd7eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Autoimmune Diseases - chemically induced</topic><topic>Autoimmune Diseases - epidemiology</topic><topic>Autoimmune disorders</topic><topic>Child</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Michigan</topic><topic>Michigan - epidemiology</topic><topic>Polybrominated Biphenyls</topic><topic>Prevalence</topic><topic>Registries</topic><topic>Rheumatoid arthritis</topic><topic>Thyroid autoimmune disorders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hood, Robert B.</creatorcontrib><creatorcontrib>Terrell, Metrecia L.</creatorcontrib><creatorcontrib>Mardovich, Sarah</creatorcontrib><creatorcontrib>Somers, Emily C.</creatorcontrib><creatorcontrib>Pearson, Melanie</creatorcontrib><creatorcontrib>Barton, Hillary</creatorcontrib><creatorcontrib>Tomlinson, Martha Scott</creatorcontrib><creatorcontrib>Marder, M. Elizabeth</creatorcontrib><creatorcontrib>Barr, Dana Boyd</creatorcontrib><creatorcontrib>Marcus, Michele</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hood, Robert B.</au><au>Terrell, Metrecia L.</au><au>Mardovich, Sarah</au><au>Somers, Emily C.</au><au>Pearson, Melanie</au><au>Barton, Hillary</au><au>Tomlinson, Martha Scott</au><au>Marder, M. Elizabeth</au><au>Barr, Dana Boyd</au><au>Marcus, Michele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polybrominated biphenyls (PBBs) and prevalence of autoimmune disorders among members of the Michigan PBB registry</atitle><jtitle>Environmental research</jtitle><addtitle>Environ Res</addtitle><date>2023-12-15</date><risdate>2023</risdate><volume>239</volume><issue>Pt 1</issue><spage>117312</spage><epage>117312</epage><pages>117312-117312</pages><artnum>117312</artnum><issn>0013-9351</issn><issn>1096-0953</issn><eissn>1096-0953</eissn><abstract>Polybrominated biphenyls (PBBs), a class of endocrine disrupting chemicals, were the main chemicals present in one of the largest industrial accidents in the United States. We investigated the association between serum PBB-153 levels and autoimmune disorders among members of the Michigan PBB Registry.
Eight hundred and ninety-five members of the registry had both a serum PBB-153 measurement and had completed one or more questionnaires about autoimmune disorders. Autoimmune disorders were examined collectively and within specific organ systems. Sex-stratified unadjusted and adjusted log-binomial models were used to examine the association between tertiles of serum PBB-153 levels and autoimmune disorders. Models were adjusted by lifestage at exposure (in utero, childhood, adulthood), smoking history (never, past, current), and total serum lipid levels (continuous). We utilized cubic spline models to investigate non-linearity between serum PBB-153 levels and the prevalence of autoimmune disorders.
Approximately 12.9% and 20.7% of male and female participants reported having one or more autoimmune disorders, respectively. After adjustment for potential confounders, we observed no association between PBB-153 tertiles and the composite classification of ‘any autoimmune disorder’ in either sex. We observed some evidence for an association between serum PBB-153 levels and rheumatoid arthritis in males and females; however, this was not statistically significant in females. We also observed some evidence for an association between serum PBB-153 levels and neurological- and thyroid-related autoimmune disorders in females, but again this was not statistically significant. Additionally, we identified dose-response curves for serum PBB-153 levels and the prevalence of autoimmune disorders that differed by lifestage of exposure and sex.
We observed some evidence that increasing serum PBB-153 levels were associated with three specified autoimmune disorders. Studies focusing on these three autoimmune disorders and the potential non-linear trend differences by lifestage of exposure warrant further investigation.
•Serum PBB-153 levels were not associated with the prevalence of autoimmune disorders as a composite outcome.•Serum PBB-153 levels may be associated with rheumatoid arthritis in males and females.•Serum PBB-153 levels may be associated with neurological and thyroid autoimmune disorders in females.•The dose-response curve between serum PBB-153 levels and autoimmune disorders may differ by lifestage exposure window.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>37806482</pmid><doi>10.1016/j.envres.2023.117312</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-2052-1685</orcidid><orcidid>https://orcid.org/0000-0002-9068-9280</orcidid><orcidid>https://orcid.org/0000-0003-3909-7084</orcidid><orcidid>https://orcid.org/0000-0001-9406-2226</orcidid><orcidid>https://orcid.org/0000-0001-9902-9206</orcidid><orcidid>https://orcid.org/0000-0001-5234-3978</orcidid></addata></record> |
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| subjects | Adult Autoimmune Diseases - chemically induced Autoimmune Diseases - epidemiology Autoimmune disorders Child Female Humans Male Michigan Michigan - epidemiology Polybrominated Biphenyls Prevalence Registries Rheumatoid arthritis Thyroid autoimmune disorders |
| title | Polybrominated biphenyls (PBBs) and prevalence of autoimmune disorders among members of the Michigan PBB registry |
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