Reduced Mitochondrial Protein Translation Promotes Cardiomyocyte Proliferation and Heart Regeneration

The importance of mitochondria in normal heart function are well recognized and recent studies have implicated changes in mitochondrial metabolism with some forms of heart disease. Previous studies demonstrated that knockdown of the mitochondrial ribosomal protein S5 (MRPS5) by small interfering RNA...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2023-12, Vol.148 (23), p.1887-1906
Hauptverfasser:	Gao, Feng, Liang, Tian, Lu, Yao Wei, Pu, Linbin, Fu, Xuyang, Dong, Xiaoxuan, Hong, Tingting, Zhang, Feng, Liu, Ning, Zhou, Yuxia, Wang, Hongkun, Liang, Ping, Guo, Yuxuan, Yu, Hong, Zhu, Wei, Hu, Xinyang, Chen, Hong, Zhou, Bin, Pu, William T, Mably, John D, Wang, Jian'an, Wang, Da-Zhi, Chen, Jinghai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation Cells, Cultured Doxycycline Humans Induced Pluripotent Stem Cells - metabolism Mice Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Myocytes, Cardiac - metabolism Protein Biosynthesis Regeneration RNA, Small Interfering - metabolism
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