Disease and Economic Burden of Poor Metabolic and Weight Control in Type 2 Diabetes in Spain: A Systematic Literature Review
Introduction Poor metabolic control and excess body weight are frequently present in people with type 2 diabetes (PwT2D). Methods A systematic literature review was conducted to identify observational studies reporting clinical, economic, and health-related quality of life (HRQoL) outcomes associate...
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| Veröffentlicht in: | Diabetes therapy 2024-02, Vol.15 (2), p.325-341 |
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| creator | Pérez, Antonio Redondo-Antón, Jennifer Romera, Irene Lizán, Luís Rubio-de Santos, Miriam Díaz-Cerezo, Silvia Orozco-Beltrán, Domingo |
| description | Introduction
Poor metabolic control and excess body weight are frequently present in people with type 2 diabetes (PwT2D).
Methods
A systematic literature review was conducted to identify observational studies reporting clinical, economic, and health-related quality of life (HRQoL) outcomes associated with poor metabolic (according to HbA1c, blood pressure [BP] and low density lipoprotein cholesterol [LDL-C] levels) and/or weight control (defined by a body mass index [BMI] ≥ 30 kg/m
2
) in adults with T2D in Spain, including articles published in either Spanish or English between 2013 and 2022 and conference abstracts from the last 2 years.
Results
Nine observational studies were included in the analysis. Poor glycemic control (HbA1c ≥ 7%) was associated with cardiovascular disease (CVD), increased requirements for antidiabetic medications, higher and more frequent weight gain, a greater probability of hypoglycemia and dyslipidemia, and worse health-related quality of life (HRQoL). Uncontrolled BP in PwT2D was related with the presence of CVD, worse metabolic control, and higher BMI and abdominal perimeter values. Poor LDL-C control or dyslipidemia was associated with CVD, hypoglycemia, and elevated HbA1c and triglycerides levels. The presence of a BMI ≥ 30 kg/m
2
was related to CVD and hypoglycemia, a higher prevalence of metabolic syndrome and worse BP control. Direct medical costs were found to be higher in PwT2D when coexisting with HbA1c levels ≥ 7%, uncontrolled BP or obesity. Increased total costs, including productivity losses, were also detected in those who presented uncontrolled BP and a BMI ≥ 30 kg/m
2
, and when poor weight control existed together with HbA1c ≥ 8% and poorly controlled BP.
Conclusion
Gathered evidence supports the high clinical, economic and HRQoL burden of poor metabolic and/or weight control in PwT2D in Spain and reinforces the importance of prioritizing its control to reduce the associated burden, at both the individual and healthcare system levels. |
| doi_str_mv | 10.1007/s13300-023-01503-4 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10838877</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A781476103</galeid><sourcerecordid>A781476103</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-3ef1b8cb26045a058935189ea5348f0cac3c89cd33ed4e57eafdeca7c6b8a59b3</originalsourceid><addsrcrecordid>eNp9kl9rFDEUxQdRbKn9Aj5IwBdfpiaTyUzii6zb-gdWFFvxMdzJ3NmmzCZrkqks-OHNOnWxICYPCbm_c7jhnqJ4yugZo7R9GRnnlJa04iVlgvKyflAcM9moslENe3i4C35UnMZ4Q_PiSinGHhdHvFVSyUodFz_PbUSISMD15MJ45zfWkDdT6NERP5DP3gfyERN0fsyFPfUN7fo6kaV3KfiRWEeudlskFTm30GHCuH-63IJ1r8iCXO5iwg2kLF7ZhAHSFJB8wVuLP54UjwYYI57enSfF17cXV8v35erTuw_Lxao0dSNSyXFgnTRd1dBaABVSccGkQhC8lgM1YLiRyvScY1-jaBGGHg20pukkCNXxk-L17Ludug32BnPnMOptsBsIO-3B6vsVZ6_12t9qRiWXsm2zw4s7h-C_TxiT3thocBzBoZ-irqSqGiEbyTL6fEbXMKK2bvDZ0uxxvWglq9uGUZ6ps39QefeYB-AdDja_3xNUs8AEH2PA4dA-o3qfCD0nQudE6N-J0HUWPfv74wfJn_lngM9AzCW3xqBv_BRcHsb_bH8BRknBUQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2892658681</pqid></control><display><type>article</type><title>Disease and Economic Burden of Poor Metabolic and Weight Control in Type 2 Diabetes in Spain: A Systematic Literature Review</title><source>Springer Nature OA Free Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Pérez, Antonio ; Redondo-Antón, Jennifer ; Romera, Irene ; Lizán, Luís ; Rubio-de Santos, Miriam ; Díaz-Cerezo, Silvia ; Orozco-Beltrán, Domingo</creator><creatorcontrib>Pérez, Antonio ; Redondo-Antón, Jennifer ; Romera, Irene ; Lizán, Luís ; Rubio-de Santos, Miriam ; Díaz-Cerezo, Silvia ; Orozco-Beltrán, Domingo</creatorcontrib><description>Introduction
Poor metabolic control and excess body weight are frequently present in people with type 2 diabetes (PwT2D).
Methods
A systematic literature review was conducted to identify observational studies reporting clinical, economic, and health-related quality of life (HRQoL) outcomes associated with poor metabolic (according to HbA1c, blood pressure [BP] and low density lipoprotein cholesterol [LDL-C] levels) and/or weight control (defined by a body mass index [BMI] ≥ 30 kg/m
2
) in adults with T2D in Spain, including articles published in either Spanish or English between 2013 and 2022 and conference abstracts from the last 2 years.
Results
Nine observational studies were included in the analysis. Poor glycemic control (HbA1c ≥ 7%) was associated with cardiovascular disease (CVD), increased requirements for antidiabetic medications, higher and more frequent weight gain, a greater probability of hypoglycemia and dyslipidemia, and worse health-related quality of life (HRQoL). Uncontrolled BP in PwT2D was related with the presence of CVD, worse metabolic control, and higher BMI and abdominal perimeter values. Poor LDL-C control or dyslipidemia was associated with CVD, hypoglycemia, and elevated HbA1c and triglycerides levels. The presence of a BMI ≥ 30 kg/m
2
was related to CVD and hypoglycemia, a higher prevalence of metabolic syndrome and worse BP control. Direct medical costs were found to be higher in PwT2D when coexisting with HbA1c levels ≥ 7%, uncontrolled BP or obesity. Increased total costs, including productivity losses, were also detected in those who presented uncontrolled BP and a BMI ≥ 30 kg/m
2
, and when poor weight control existed together with HbA1c ≥ 8% and poorly controlled BP.
Conclusion
Gathered evidence supports the high clinical, economic and HRQoL burden of poor metabolic and/or weight control in PwT2D in Spain and reinforces the importance of prioritizing its control to reduce the associated burden, at both the individual and healthcare system levels.</description><identifier>ISSN: 1869-6953</identifier><identifier>EISSN: 1869-6961</identifier><identifier>DOI: 10.1007/s13300-023-01503-4</identifier><identifier>PMID: 37989829</identifier><language>eng</language><publisher>Cheshire: Springer Healthcare</publisher><subject>Cardiology ; Complications and side effects ; Diabetes ; Diabetes therapy ; Economic aspects ; Endocrinology ; Evaluation ; Finance ; Health aspects ; Internal Medicine ; Medical care, Cost of ; Medicine ; Medicine & Public Health ; Quality of life ; Review ; Type 2 diabetes</subject><ispartof>Diabetes therapy, 2024-02, Vol.15 (2), p.325-341</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>COPYRIGHT 2024 Springer</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c465t-3ef1b8cb26045a058935189ea5348f0cac3c89cd33ed4e57eafdeca7c6b8a59b3</cites><orcidid>0000-0003-2661-5866</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10838877/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10838877/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,41118,42187,51574,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37989829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pérez, Antonio</creatorcontrib><creatorcontrib>Redondo-Antón, Jennifer</creatorcontrib><creatorcontrib>Romera, Irene</creatorcontrib><creatorcontrib>Lizán, Luís</creatorcontrib><creatorcontrib>Rubio-de Santos, Miriam</creatorcontrib><creatorcontrib>Díaz-Cerezo, Silvia</creatorcontrib><creatorcontrib>Orozco-Beltrán, Domingo</creatorcontrib><title>Disease and Economic Burden of Poor Metabolic and Weight Control in Type 2 Diabetes in Spain: A Systematic Literature Review</title><title>Diabetes therapy</title><addtitle>Diabetes Ther</addtitle><addtitle>Diabetes Ther</addtitle><description>Introduction
Poor metabolic control and excess body weight are frequently present in people with type 2 diabetes (PwT2D).
Methods
A systematic literature review was conducted to identify observational studies reporting clinical, economic, and health-related quality of life (HRQoL) outcomes associated with poor metabolic (according to HbA1c, blood pressure [BP] and low density lipoprotein cholesterol [LDL-C] levels) and/or weight control (defined by a body mass index [BMI] ≥ 30 kg/m
2
) in adults with T2D in Spain, including articles published in either Spanish or English between 2013 and 2022 and conference abstracts from the last 2 years.
Results
Nine observational studies were included in the analysis. Poor glycemic control (HbA1c ≥ 7%) was associated with cardiovascular disease (CVD), increased requirements for antidiabetic medications, higher and more frequent weight gain, a greater probability of hypoglycemia and dyslipidemia, and worse health-related quality of life (HRQoL). Uncontrolled BP in PwT2D was related with the presence of CVD, worse metabolic control, and higher BMI and abdominal perimeter values. Poor LDL-C control or dyslipidemia was associated with CVD, hypoglycemia, and elevated HbA1c and triglycerides levels. The presence of a BMI ≥ 30 kg/m
2
was related to CVD and hypoglycemia, a higher prevalence of metabolic syndrome and worse BP control. Direct medical costs were found to be higher in PwT2D when coexisting with HbA1c levels ≥ 7%, uncontrolled BP or obesity. Increased total costs, including productivity losses, were also detected in those who presented uncontrolled BP and a BMI ≥ 30 kg/m
2
, and when poor weight control existed together with HbA1c ≥ 8% and poorly controlled BP.
Conclusion
Gathered evidence supports the high clinical, economic and HRQoL burden of poor metabolic and/or weight control in PwT2D in Spain and reinforces the importance of prioritizing its control to reduce the associated burden, at both the individual and healthcare system levels.</description><subject>Cardiology</subject><subject>Complications and side effects</subject><subject>Diabetes</subject><subject>Diabetes therapy</subject><subject>Economic aspects</subject><subject>Endocrinology</subject><subject>Evaluation</subject><subject>Finance</subject><subject>Health aspects</subject><subject>Internal Medicine</subject><subject>Medical care, Cost of</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Quality of life</subject><subject>Review</subject><subject>Type 2 diabetes</subject><issn>1869-6953</issn><issn>1869-6961</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kl9rFDEUxQdRbKn9Aj5IwBdfpiaTyUzii6zb-gdWFFvxMdzJ3NmmzCZrkqks-OHNOnWxICYPCbm_c7jhnqJ4yugZo7R9GRnnlJa04iVlgvKyflAcM9moslENe3i4C35UnMZ4Q_PiSinGHhdHvFVSyUodFz_PbUSISMD15MJ45zfWkDdT6NERP5DP3gfyERN0fsyFPfUN7fo6kaV3KfiRWEeudlskFTm30GHCuH-63IJ1r8iCXO5iwg2kLF7ZhAHSFJB8wVuLP54UjwYYI57enSfF17cXV8v35erTuw_Lxao0dSNSyXFgnTRd1dBaABVSccGkQhC8lgM1YLiRyvScY1-jaBGGHg20pukkCNXxk-L17Ludug32BnPnMOptsBsIO-3B6vsVZ6_12t9qRiWXsm2zw4s7h-C_TxiT3thocBzBoZ-irqSqGiEbyTL6fEbXMKK2bvDZ0uxxvWglq9uGUZ6ps39QefeYB-AdDja_3xNUs8AEH2PA4dA-o3qfCD0nQudE6N-J0HUWPfv74wfJn_lngM9AzCW3xqBv_BRcHsb_bH8BRknBUQ</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Pérez, Antonio</creator><creator>Redondo-Antón, Jennifer</creator><creator>Romera, Irene</creator><creator>Lizán, Luís</creator><creator>Rubio-de Santos, Miriam</creator><creator>Díaz-Cerezo, Silvia</creator><creator>Orozco-Beltrán, Domingo</creator><general>Springer Healthcare</general><general>Springer</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2661-5866</orcidid></search><sort><creationdate>20240201</creationdate><title>Disease and Economic Burden of Poor Metabolic and Weight Control in Type 2 Diabetes in Spain: A Systematic Literature Review</title><author>Pérez, Antonio ; Redondo-Antón, Jennifer ; Romera, Irene ; Lizán, Luís ; Rubio-de Santos, Miriam ; Díaz-Cerezo, Silvia ; Orozco-Beltrán, Domingo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-3ef1b8cb26045a058935189ea5348f0cac3c89cd33ed4e57eafdeca7c6b8a59b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cardiology</topic><topic>Complications and side effects</topic><topic>Diabetes</topic><topic>Diabetes therapy</topic><topic>Economic aspects</topic><topic>Endocrinology</topic><topic>Evaluation</topic><topic>Finance</topic><topic>Health aspects</topic><topic>Internal Medicine</topic><topic>Medical care, Cost of</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Quality of life</topic><topic>Review</topic><topic>Type 2 diabetes</topic><toplevel>online_resources</toplevel><creatorcontrib>Pérez, Antonio</creatorcontrib><creatorcontrib>Redondo-Antón, Jennifer</creatorcontrib><creatorcontrib>Romera, Irene</creatorcontrib><creatorcontrib>Lizán, Luís</creatorcontrib><creatorcontrib>Rubio-de Santos, Miriam</creatorcontrib><creatorcontrib>Díaz-Cerezo, Silvia</creatorcontrib><creatorcontrib>Orozco-Beltrán, Domingo</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetes therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pérez, Antonio</au><au>Redondo-Antón, Jennifer</au><au>Romera, Irene</au><au>Lizán, Luís</au><au>Rubio-de Santos, Miriam</au><au>Díaz-Cerezo, Silvia</au><au>Orozco-Beltrán, Domingo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disease and Economic Burden of Poor Metabolic and Weight Control in Type 2 Diabetes in Spain: A Systematic Literature Review</atitle><jtitle>Diabetes therapy</jtitle><stitle>Diabetes Ther</stitle><addtitle>Diabetes Ther</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>15</volume><issue>2</issue><spage>325</spage><epage>341</epage><pages>325-341</pages><issn>1869-6953</issn><eissn>1869-6961</eissn><abstract>Introduction
Poor metabolic control and excess body weight are frequently present in people with type 2 diabetes (PwT2D).
Methods
A systematic literature review was conducted to identify observational studies reporting clinical, economic, and health-related quality of life (HRQoL) outcomes associated with poor metabolic (according to HbA1c, blood pressure [BP] and low density lipoprotein cholesterol [LDL-C] levels) and/or weight control (defined by a body mass index [BMI] ≥ 30 kg/m
2
) in adults with T2D in Spain, including articles published in either Spanish or English between 2013 and 2022 and conference abstracts from the last 2 years.
Results
Nine observational studies were included in the analysis. Poor glycemic control (HbA1c ≥ 7%) was associated with cardiovascular disease (CVD), increased requirements for antidiabetic medications, higher and more frequent weight gain, a greater probability of hypoglycemia and dyslipidemia, and worse health-related quality of life (HRQoL). Uncontrolled BP in PwT2D was related with the presence of CVD, worse metabolic control, and higher BMI and abdominal perimeter values. Poor LDL-C control or dyslipidemia was associated with CVD, hypoglycemia, and elevated HbA1c and triglycerides levels. The presence of a BMI ≥ 30 kg/m
2
was related to CVD and hypoglycemia, a higher prevalence of metabolic syndrome and worse BP control. Direct medical costs were found to be higher in PwT2D when coexisting with HbA1c levels ≥ 7%, uncontrolled BP or obesity. Increased total costs, including productivity losses, were also detected in those who presented uncontrolled BP and a BMI ≥ 30 kg/m
2
, and when poor weight control existed together with HbA1c ≥ 8% and poorly controlled BP.
Conclusion
Gathered evidence supports the high clinical, economic and HRQoL burden of poor metabolic and/or weight control in PwT2D in Spain and reinforces the importance of prioritizing its control to reduce the associated burden, at both the individual and healthcare system levels.</abstract><cop>Cheshire</cop><pub>Springer Healthcare</pub><pmid>37989829</pmid><doi>10.1007/s13300-023-01503-4</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0003-2661-5866</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Diabetes therapy, 2024-02, Vol.15 (2), p.325-341 |
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| source | Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Cardiology Complications and side effects Diabetes Diabetes therapy Economic aspects Endocrinology Evaluation Finance Health aspects Internal Medicine Medical care, Cost of Medicine Medicine & Public Health Quality of life Review Type 2 diabetes |
| title | Disease and Economic Burden of Poor Metabolic and Weight Control in Type 2 Diabetes in Spain: A Systematic Literature Review |
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