Messenger RNAs that are not synthesized by RNA polymerase II can be 3′ end cleaved and polyadenylated

The poly(A) tail of influenza virus mRNAs is synthesized by the viral RNA polymerase by reiterative copying of a U 5–7 sequence near the 5′ end of the viral RNA (vRNA) template. We have engineered a vRNA molecule by replacing its viral U 6 poly(A) site with a negative‐sense eukaryotic polyadenylatio...

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Veröffentlicht in:	EMBO reports 2000-12, Vol.1 (6), p.513-518
Hauptverfasser:	Fodor, Ervin, Mikulasova, Andrea, Mingay, Louise J, Poon, Leo L M, Brownlee, George G
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Cell Line Cloning, Molecular Humans Influenza, Human - genetics Molecular Sequence Data Mutagenesis Neuraminidase - genetics Plasmids - metabolism Poly A - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Polymerase II - metabolism RNA, Messenger - metabolism RNA, Viral - physiology RNA, Viral - ultrastructure Scientific Report Scientific Reports Single-Strand Specific DNA and RNA Endonucleases - metabolism Time Factors Transcription, Genetic Transfection
Online-Zugang:	Volltext
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