Fibrin degradation products in the cerebrospinal fluid of patients with pneumococcal meningitis
Raised levels of fibrin degradation products were found in the cerebrospinal fluid of nearly all of 35 patients with pneumococcal meningitis. The mean level was higher in patients who died subsequently than in those who survived. Cerebrospinal fluid from patients with pneumococcal meningitis showed...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1979-09, Vol.42 (9), p.843-846 |
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| container_end_page | 846 |
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| container_issue | 9 |
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| container_title | Journal of neurology, neurosurgery and psychiatry |
| container_volume | 42 |
| creator | Cleland, P G Macfarlane, J T Baird, D R Greenwood, B M |
| description | Raised levels of fibrin degradation products were found in the cerebrospinal fluid of nearly all of 35 patients with pneumococcal meningitis. The mean level was higher in patients who died subsequently than in those who survived. Cerebrospinal fluid from patients with pneumococcal meningitis showed increased fibrinolytic activity as assessed by clot lysis, suggesting local production of fibrin degradation products within the subarachnoid space. |
| doi_str_mv | 10.1136/jnnp.42.9.843 |
| format | Article |
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The mean level was higher in patients who died subsequently than in those who survived. Cerebrospinal fluid from patients with pneumococcal meningitis showed increased fibrinolytic activity as assessed by clot lysis, suggesting local production of fibrin degradation products within the subarachnoid space.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.42.9.843</identifier><identifier>PMID: 501385</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd</publisher><subject>Adult ; Female ; Fibrin Fibrinogen Degradation Products - cerebrospinal fluid ; Fibrinogen - cerebrospinal fluid ; Fibrinolysis ; Humans ; Male ; Meningitis, Meningococcal - cerebrospinal fluid ; Meningitis, Pneumococcal - cerebrospinal fluid</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 1979-09, Vol.42 (9), p.843-846</ispartof><rights>Copyright BMJ Publishing Group LTD Sep 1979</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b480t-edeac5e3eacd8c0071110ea881b5abacb474f8b06480685c50f806ae7bd5e73b3</citedby><cites>FETCH-LOGICAL-b480t-edeac5e3eacd8c0071110ea881b5abacb474f8b06480685c50f806ae7bd5e73b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082975/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082975/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/501385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cleland, P G</creatorcontrib><creatorcontrib>Macfarlane, J T</creatorcontrib><creatorcontrib>Baird, D R</creatorcontrib><creatorcontrib>Greenwood, B M</creatorcontrib><title>Fibrin degradation products in the cerebrospinal fluid of patients with pneumococcal meningitis</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>Raised levels of fibrin degradation products were found in the cerebrospinal fluid of nearly all of 35 patients with pneumococcal meningitis. The mean level was higher in patients who died subsequently than in those who survived. Cerebrospinal fluid from patients with pneumococcal meningitis showed increased fibrinolytic activity as assessed by clot lysis, suggesting local production of fibrin degradation products within the subarachnoid space.</description><subject>Adult</subject><subject>Female</subject><subject>Fibrin Fibrinogen Degradation Products - cerebrospinal fluid</subject><subject>Fibrinogen - cerebrospinal fluid</subject><subject>Fibrinolysis</subject><subject>Humans</subject><subject>Male</subject><subject>Meningitis, Meningococcal - cerebrospinal fluid</subject><subject>Meningitis, Pneumococcal - cerebrospinal fluid</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUuP0zAUhS3Eqwws2bGIhITYpNhxXDubkVChA2gEC2DE7sp2blqXxA52wuPf49JReWzwwrZ8P597dA8hDxldMsZXz_bej8u6WjZLVfMbZMHqlSo5p59ukgWlVVVyKuhdci-lPT0s1dwhtwVlXIkFgY0z0fmixW3UrZ5c8MUYQzvbKRX5fdphYTGiiSGNzuu-6PrZtUXoijHT6DP2zU27YvQ4D8EGazMzoHd-6yaX7pNbne4TPrg-z8jHzcsP61fl5buL1-vnl6WpFZ1KbFFbgTzvrbKUSsYYRa0UM0IbbU0t604Zusr0SgkraJcvGqVpBUpu-Bk5P-qOsxmwtdlY1D2M0Q06_oCgHfxd8W4H2_AVGFVVI0UWeHItEMOXGdMEg0sW-157DHMCmTsL8Qt8_A-4D3PMk0nApKxyBhVtMlUeKZsHlyJ2JyuMwiE2OMQGdQUN5C-Zf_Sn_xN9zOm3nEsTfj9VdfwMK8mlgLdXa3hRXzXvNxcK3mT-6ZE3w_4_nX8CknmzJQ</recordid><startdate>19790901</startdate><enddate>19790901</enddate><creator>Cleland, P G</creator><creator>Macfarlane, J T</creator><creator>Baird, D R</creator><creator>Greenwood, B M</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19790901</creationdate><title>Fibrin degradation products in the cerebrospinal fluid of patients with pneumococcal meningitis</title><author>Cleland, P G ; Macfarlane, J T ; Baird, D R ; Greenwood, B M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b480t-edeac5e3eacd8c0071110ea881b5abacb474f8b06480685c50f806ae7bd5e73b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Adult</topic><topic>Female</topic><topic>Fibrin Fibrinogen Degradation Products - cerebrospinal fluid</topic><topic>Fibrinogen - cerebrospinal fluid</topic><topic>Fibrinolysis</topic><topic>Humans</topic><topic>Male</topic><topic>Meningitis, Meningococcal - cerebrospinal fluid</topic><topic>Meningitis, Pneumococcal - cerebrospinal fluid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cleland, P G</creatorcontrib><creatorcontrib>Macfarlane, J T</creatorcontrib><creatorcontrib>Baird, D R</creatorcontrib><creatorcontrib>Greenwood, B M</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database (ProQuest)</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cleland, P G</au><au>Macfarlane, J T</au><au>Baird, D R</au><au>Greenwood, B M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fibrin degradation products in the cerebrospinal fluid of patients with pneumococcal meningitis</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>1979-09-01</date><risdate>1979</risdate><volume>42</volume><issue>9</issue><spage>843</spage><epage>846</epage><pages>843-846</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>Raised levels of fibrin degradation products were found in the cerebrospinal fluid of nearly all of 35 patients with pneumococcal meningitis. The mean level was higher in patients who died subsequently than in those who survived. Cerebrospinal fluid from patients with pneumococcal meningitis showed increased fibrinolytic activity as assessed by clot lysis, suggesting local production of fibrin degradation products within the subarachnoid space.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd</pub><pmid>501385</pmid><doi>10.1136/jnnp.42.9.843</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-3050 |
| ispartof | Journal of neurology, neurosurgery and psychiatry, 1979-09, Vol.42 (9), p.843-846 |
| issn | 0022-3050 1468-330X |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Female Fibrin Fibrinogen Degradation Products - cerebrospinal fluid Fibrinogen - cerebrospinal fluid Fibrinolysis Humans Male Meningitis, Meningococcal - cerebrospinal fluid Meningitis, Pneumococcal - cerebrospinal fluid |
| title | Fibrin degradation products in the cerebrospinal fluid of patients with pneumococcal meningitis |
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