Maternal Repetitive Hypoxia Prior to Mating Confers Epigenetic Resilience to Memory Impairment in Male Progeny

We showed previously in a mouse model of vascular cognitive impairment and dementia involving chronic cerebral hypoperfusion (CCH) that repetitive hypoxic conditioning (RHC) of both parents results in the epigenetic, intergenerational transmission of resilience to recognition memory loss in adult pr...

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Veröffentlicht in:	Behavioral neuroscience 2023-06, Vol.137 (3), p.178-183
Hauptverfasser:	Broyles, Emrey E., Corell, David H., Gidday, Jeffrey M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Animals Anoxia Brain Ischemia Cognitive ability Cognitive Dysfunction - genetics Dementia Dementia disorders Disease Models, Animal Disease transmission Epigenesis, Genetic Epigenetics Female Germ cells Hypoxia Male Males Memory Memory Disorders Memory Disorders - genetics Mice Offspring Pattern recognition Phenotypes Recognition (Learning) Resilience (Psychological) Sexual dimorphism Transgenerational Patterns Vascular dementia
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