Coronary and carotid artery dysfunction and KV7 overexpression in a mouse model of Hutchinson-Gilford progeria syndrome

Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disease caused by expression of progerin, a lamin A variant that is also expressed at low levels in non-HGPS individuals. Although HGPS patients die predominantly from myocardial infarction and stroke, the mechanisms that provo...

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Veröffentlicht in:	GeroScience 2024-02, Vol.46 (1), p.867-884
Hauptverfasser:	Macías, Álvaro, Nevado, Rosa M., González-Gómez, Cristina, Gonzalo, Pilar, Andrés-Manzano, María Jesús, Dorado, Beatriz, Benedicto, Ignacio, Andrés, Vicente
Format:	Artikel
Sprache:	eng
Schlagworte:	Aorta Biomedical and Life Sciences Carotid arteries Carotid artery Cell Biology Cerebral infarction Coronary artery Gene expression Genetic disorders Geriatrics/Gerontology Heart Hypoxia Hypoxia-inducible factor 1a Hypoxia-inducible factors Life Sciences Molecular Medicine Myocardial infarction Original Original Article Potassium channels (voltage-gated) Progeria Smooth muscle Stenosis Vascularization
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