Selective inhibition of overactive warmth-sensitive Ca2+-permeable TRPV3 channels by antispasmodic agent flopropione for alleviation of skin inflammation

The temperature-sensitive Ca2+-permeable TRPV3 ion channel is robustly expressed in the skin keratinocytes, and its gain-of-function mutations are involved in the pathology of skin lesions. Here, we report the identification of an antispasmodic agent flopropione that alleviates skin inflammation by...

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Veröffentlicht in:	The Journal of biological chemistry 2024-02, Vol.300 (2), p.105595, Article 105595
Hauptverfasser:	Xu, Yimei, Qu, Yaxuan, Zhang, Congxiao, Niu, Canyang, Tang, Xiaowen, Sun, Xiaoying, Wang, KeWei
Format:	Artikel
Sprache:	eng
Schlagworte:	docking drug repurposing electrophysiology flopropione TRPV3
Online-Zugang:	Volltext
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