Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study
Growth differentiation factor-15 (GDF15) might be involved in the development of cognitive frailty and depression. Therefore, we evaluated cross-sectional associations of plasma GDF15 with combined cognitive-frailty-and-depression in older (i.e. ≥ 55 years) and younger adults of the MARK-AGE study....
Gespeichert in:
| Veröffentlicht in: | GeroScience 2024-04, Vol.46 (2), p.1657-1669 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1669 |
|---|---|
| container_issue | 2 |
| container_start_page | 1657 |
| container_title | GeroScience |
| container_volume | 46 |
| creator | Kochlik, Bastian Herpich, Catrin Moreno-Villanueva, María Klaus, Susanne Müller-Werdan, Ursula Weinberger, Birgit Fiegl, Simone Toussaint, Olivier Debacq-Chainiaux, Florence Schön, Christiane Bernhard, Jürgen Breusing, Nicolle Gonos, Efstathios S. Franceschi, Claudio Capri, Miriam Sikora, Ewa Hervonen, Antti Hurme, Mikko Slagboom, P. Eline Dollé, Martijn E. T. Jansen, Eugene Grune, Tilman Bürkle, Alexander Norman, Kristina |
| description | Growth differentiation factor-15 (GDF15) might be involved in the development of cognitive frailty and depression. Therefore, we evaluated cross-sectional associations of plasma GDF15 with combined cognitive-frailty-and-depression in older (i.e. ≥ 55 years) and younger adults of the MARK-AGE study. In the present work, samples and data of MARK-AGE (“European study to establish bioMARKers of human AGEing“) participants (
N
= 2736) were analyzed. Cognitive frailty was determined by the global cognitive functioning score (GCF) and depression by the Self-Rating Depression Scale (SDS score). Adults were classified into three groups: (I) neither-cognitive-frailty-nor-depression, (II) either-cognitive-frailty-or-depression or (III) both-cognitive-frailty-and-depression. Cross-sectional associations were determined by unadjusted and by age, BMI, sex, comorbidities and hsCRP-adjusted linear and logistic regression analyses. Cognitive frailty, depression, age and GDF15 were significantly related within the whole study sample. High GDF15 levels were significantly associated with both-cognitive-frailty-and-depression (adjusted β = 0.177 [0.044 – 0.310],
p
= 0.009), and with low GCF scores and high SDS scores. High GDF15 concentrations and quartiles were significantly associated with higher odds to have both-cognitive-frailty-and-depression (adjusted odds ratio = 2.353 [1.267 – 4.372],
p
= 0.007; and adjusted odds ratio = 1.414 [1.025 – 1.951],
p
= 0.035, respectively) independent of age, BMI, sex, comorbidities and hsCRP. These associations remained significant when evaluating older adults. We conclude that plasma GDF15 concentrations are significantly associated with combined cognitive-frailty-and-depression status and, with cognitive frailty and depressive symptoms separately in old as well as young community-dwelling adults. |
| doi_str_mv | 10.1007/s11357-023-00902-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10828354</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2920223418</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-c3ffc5456e57fc64996fdcb01f637f629b48af5769aa14782f2d658035bded283</originalsourceid><addsrcrecordid>eNp9kU1vEzEQhlcIRKvSP8ABWeLCZenYXtu7JxT1I1QUISE4W15_JK42drC9Qfn3uE0phQMnjzXv-8yM3qZ5jeE9BhBnGWPKRAuEtgADkJY_a44Jg6ElgtDnT-qj5jTnWwDAgnMK8LI5okJg1nf0uNktco7aq-JjyCg6pH3S81T_YYWWF1eYoZ--rJGOm9EHa2qxCr74nUUuKT-VPVLBIGO3yeZcIcgHFCdjE1Jmnso9s6wt-rz4-qldLC9RLrPZv2peODVle_rwnjTfry6_nX9sb74sr88XN63uBCutps5p1jFumXCad8PAndEjYMepcJwMY9crxwQflMKd6IkjhrMeKBuNNaSnJ82HA3c7jxtrtA0lqUluk9-otJdRefl3J_i1XMWdxNBXO-sq4d0DIcUfs81FbnzWdppUsHHOkvSciTpxwFX69h_pbZxTqPdJMhAghHb4biVyUOkUc07WPW6DQd5FKw_RyhqtvI9W8mp68_SOR8vvIKuAHgS5tsLKpj-z_4P9BX-MrzU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2920223418</pqid></control><display><type>article</type><title>Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Kochlik, Bastian ; Herpich, Catrin ; Moreno-Villanueva, María ; Klaus, Susanne ; Müller-Werdan, Ursula ; Weinberger, Birgit ; Fiegl, Simone ; Toussaint, Olivier ; Debacq-Chainiaux, Florence ; Schön, Christiane ; Bernhard, Jürgen ; Breusing, Nicolle ; Gonos, Efstathios S. ; Franceschi, Claudio ; Capri, Miriam ; Sikora, Ewa ; Hervonen, Antti ; Hurme, Mikko ; Slagboom, P. Eline ; Dollé, Martijn E. T. ; Jansen, Eugene ; Grune, Tilman ; Bürkle, Alexander ; Norman, Kristina</creator><creatorcontrib>Kochlik, Bastian ; Herpich, Catrin ; Moreno-Villanueva, María ; Klaus, Susanne ; Müller-Werdan, Ursula ; Weinberger, Birgit ; Fiegl, Simone ; Toussaint, Olivier ; Debacq-Chainiaux, Florence ; Schön, Christiane ; Bernhard, Jürgen ; Breusing, Nicolle ; Gonos, Efstathios S. ; Franceschi, Claudio ; Capri, Miriam ; Sikora, Ewa ; Hervonen, Antti ; Hurme, Mikko ; Slagboom, P. Eline ; Dollé, Martijn E. T. ; Jansen, Eugene ; Grune, Tilman ; Bürkle, Alexander ; Norman, Kristina</creatorcontrib><description>Growth differentiation factor-15 (GDF15) might be involved in the development of cognitive frailty and depression. Therefore, we evaluated cross-sectional associations of plasma GDF15 with combined cognitive-frailty-and-depression in older (i.e. ≥ 55 years) and younger adults of the MARK-AGE study. In the present work, samples and data of MARK-AGE (“European study to establish bioMARKers of human AGEing“) participants (
N
= 2736) were analyzed. Cognitive frailty was determined by the global cognitive functioning score (GCF) and depression by the Self-Rating Depression Scale (SDS score). Adults were classified into three groups: (I) neither-cognitive-frailty-nor-depression, (II) either-cognitive-frailty-or-depression or (III) both-cognitive-frailty-and-depression. Cross-sectional associations were determined by unadjusted and by age, BMI, sex, comorbidities and hsCRP-adjusted linear and logistic regression analyses. Cognitive frailty, depression, age and GDF15 were significantly related within the whole study sample. High GDF15 levels were significantly associated with both-cognitive-frailty-and-depression (adjusted β = 0.177 [0.044 – 0.310],
p
= 0.009), and with low GCF scores and high SDS scores. High GDF15 concentrations and quartiles were significantly associated with higher odds to have both-cognitive-frailty-and-depression (adjusted odds ratio = 2.353 [1.267 – 4.372],
p
= 0.007; and adjusted odds ratio = 1.414 [1.025 – 1.951],
p
= 0.035, respectively) independent of age, BMI, sex, comorbidities and hsCRP. These associations remained significant when evaluating older adults. We conclude that plasma GDF15 concentrations are significantly associated with combined cognitive-frailty-and-depression status and, with cognitive frailty and depressive symptoms separately in old as well as young community-dwelling adults.</description><identifier>ISSN: 2509-2723</identifier><identifier>ISSN: 2509-2715</identifier><identifier>EISSN: 2509-2723</identifier><identifier>DOI: 10.1007/s11357-023-00902-6</identifier><identifier>PMID: 37715843</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Age ; Aged ; Aging ; Biomedical and Life Sciences ; C-Reactive Protein ; Cell Biology ; Cognition ; Cognitive ability ; Comorbidity ; Cross-Sectional Studies ; Depression - epidemiology ; Frail Elderly - psychology ; Frailty ; Geriatrics/Gerontology ; Growth Differentiation Factor 15 ; Humans ; Life Sciences ; Mental depression ; Molecular Medicine ; Older people ; Original ; Original Article</subject><ispartof>GeroScience, 2024-04, Vol.46 (2), p.1657-1669</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-c3ffc5456e57fc64996fdcb01f637f629b48af5769aa14782f2d658035bded283</citedby><cites>FETCH-LOGICAL-c475t-c3ffc5456e57fc64996fdcb01f637f629b48af5769aa14782f2d658035bded283</cites><orcidid>0000-0002-8614-1044 ; 0000-0002-7084-946X ; 0000-0002-1111-1748 ; 0000-0003-4775-9973 ; 0000-0003-3949-395X ; 0000-0001-9841-6386 ; 0000-0002-2875-4723 ; 0000-0003-4440-8991 ; 0000-0003-0214-7092 ; 0000-0001-6137-6544 ; 0000-0002-3151-5897 ; 0000-0003-2029-9102 ; 0000-0001-9077-0401 ; 0000-0003-3787-5268 ; 0000-0003-1069-2656 ; 0000-0003-3059-1705 ; 0000-0001-8726-185X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828354/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828354/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37715843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kochlik, Bastian</creatorcontrib><creatorcontrib>Herpich, Catrin</creatorcontrib><creatorcontrib>Moreno-Villanueva, María</creatorcontrib><creatorcontrib>Klaus, Susanne</creatorcontrib><creatorcontrib>Müller-Werdan, Ursula</creatorcontrib><creatorcontrib>Weinberger, Birgit</creatorcontrib><creatorcontrib>Fiegl, Simone</creatorcontrib><creatorcontrib>Toussaint, Olivier</creatorcontrib><creatorcontrib>Debacq-Chainiaux, Florence</creatorcontrib><creatorcontrib>Schön, Christiane</creatorcontrib><creatorcontrib>Bernhard, Jürgen</creatorcontrib><creatorcontrib>Breusing, Nicolle</creatorcontrib><creatorcontrib>Gonos, Efstathios S.</creatorcontrib><creatorcontrib>Franceschi, Claudio</creatorcontrib><creatorcontrib>Capri, Miriam</creatorcontrib><creatorcontrib>Sikora, Ewa</creatorcontrib><creatorcontrib>Hervonen, Antti</creatorcontrib><creatorcontrib>Hurme, Mikko</creatorcontrib><creatorcontrib>Slagboom, P. Eline</creatorcontrib><creatorcontrib>Dollé, Martijn E. T.</creatorcontrib><creatorcontrib>Jansen, Eugene</creatorcontrib><creatorcontrib>Grune, Tilman</creatorcontrib><creatorcontrib>Bürkle, Alexander</creatorcontrib><creatorcontrib>Norman, Kristina</creatorcontrib><title>Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study</title><title>GeroScience</title><addtitle>GeroScience</addtitle><addtitle>Geroscience</addtitle><description>Growth differentiation factor-15 (GDF15) might be involved in the development of cognitive frailty and depression. Therefore, we evaluated cross-sectional associations of plasma GDF15 with combined cognitive-frailty-and-depression in older (i.e. ≥ 55 years) and younger adults of the MARK-AGE study. In the present work, samples and data of MARK-AGE (“European study to establish bioMARKers of human AGEing“) participants (
N
= 2736) were analyzed. Cognitive frailty was determined by the global cognitive functioning score (GCF) and depression by the Self-Rating Depression Scale (SDS score). Adults were classified into three groups: (I) neither-cognitive-frailty-nor-depression, (II) either-cognitive-frailty-or-depression or (III) both-cognitive-frailty-and-depression. Cross-sectional associations were determined by unadjusted and by age, BMI, sex, comorbidities and hsCRP-adjusted linear and logistic regression analyses. Cognitive frailty, depression, age and GDF15 were significantly related within the whole study sample. High GDF15 levels were significantly associated with both-cognitive-frailty-and-depression (adjusted β = 0.177 [0.044 – 0.310],
p
= 0.009), and with low GCF scores and high SDS scores. High GDF15 concentrations and quartiles were significantly associated with higher odds to have both-cognitive-frailty-and-depression (adjusted odds ratio = 2.353 [1.267 – 4.372],
p
= 0.007; and adjusted odds ratio = 1.414 [1.025 – 1.951],
p
= 0.035, respectively) independent of age, BMI, sex, comorbidities and hsCRP. These associations remained significant when evaluating older adults. We conclude that plasma GDF15 concentrations are significantly associated with combined cognitive-frailty-and-depression status and, with cognitive frailty and depressive symptoms separately in old as well as young community-dwelling adults.</description><subject>Age</subject><subject>Aged</subject><subject>Aging</subject><subject>Biomedical and Life Sciences</subject><subject>C-Reactive Protein</subject><subject>Cell Biology</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Comorbidity</subject><subject>Cross-Sectional Studies</subject><subject>Depression - epidemiology</subject><subject>Frail Elderly - psychology</subject><subject>Frailty</subject><subject>Geriatrics/Gerontology</subject><subject>Growth Differentiation Factor 15</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Mental depression</subject><subject>Molecular Medicine</subject><subject>Older people</subject><subject>Original</subject><subject>Original Article</subject><issn>2509-2723</issn><issn>2509-2715</issn><issn>2509-2723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kU1vEzEQhlcIRKvSP8ABWeLCZenYXtu7JxT1I1QUISE4W15_JK42drC9Qfn3uE0phQMnjzXv-8yM3qZ5jeE9BhBnGWPKRAuEtgADkJY_a44Jg6ElgtDnT-qj5jTnWwDAgnMK8LI5okJg1nf0uNktco7aq-JjyCg6pH3S81T_YYWWF1eYoZ--rJGOm9EHa2qxCr74nUUuKT-VPVLBIGO3yeZcIcgHFCdjE1Jmnso9s6wt-rz4-qldLC9RLrPZv2peODVle_rwnjTfry6_nX9sb74sr88XN63uBCutps5p1jFumXCad8PAndEjYMepcJwMY9crxwQflMKd6IkjhrMeKBuNNaSnJ82HA3c7jxtrtA0lqUluk9-otJdRefl3J_i1XMWdxNBXO-sq4d0DIcUfs81FbnzWdppUsHHOkvSciTpxwFX69h_pbZxTqPdJMhAghHb4biVyUOkUc07WPW6DQd5FKw_RyhqtvI9W8mp68_SOR8vvIKuAHgS5tsLKpj-z_4P9BX-MrzU</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Kochlik, Bastian</creator><creator>Herpich, Catrin</creator><creator>Moreno-Villanueva, María</creator><creator>Klaus, Susanne</creator><creator>Müller-Werdan, Ursula</creator><creator>Weinberger, Birgit</creator><creator>Fiegl, Simone</creator><creator>Toussaint, Olivier</creator><creator>Debacq-Chainiaux, Florence</creator><creator>Schön, Christiane</creator><creator>Bernhard, Jürgen</creator><creator>Breusing, Nicolle</creator><creator>Gonos, Efstathios S.</creator><creator>Franceschi, Claudio</creator><creator>Capri, Miriam</creator><creator>Sikora, Ewa</creator><creator>Hervonen, Antti</creator><creator>Hurme, Mikko</creator><creator>Slagboom, P. Eline</creator><creator>Dollé, Martijn E. T.</creator><creator>Jansen, Eugene</creator><creator>Grune, Tilman</creator><creator>Bürkle, Alexander</creator><creator>Norman, Kristina</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8614-1044</orcidid><orcidid>https://orcid.org/0000-0002-7084-946X</orcidid><orcidid>https://orcid.org/0000-0002-1111-1748</orcidid><orcidid>https://orcid.org/0000-0003-4775-9973</orcidid><orcidid>https://orcid.org/0000-0003-3949-395X</orcidid><orcidid>https://orcid.org/0000-0001-9841-6386</orcidid><orcidid>https://orcid.org/0000-0002-2875-4723</orcidid><orcidid>https://orcid.org/0000-0003-4440-8991</orcidid><orcidid>https://orcid.org/0000-0003-0214-7092</orcidid><orcidid>https://orcid.org/0000-0001-6137-6544</orcidid><orcidid>https://orcid.org/0000-0002-3151-5897</orcidid><orcidid>https://orcid.org/0000-0003-2029-9102</orcidid><orcidid>https://orcid.org/0000-0001-9077-0401</orcidid><orcidid>https://orcid.org/0000-0003-3787-5268</orcidid><orcidid>https://orcid.org/0000-0003-1069-2656</orcidid><orcidid>https://orcid.org/0000-0003-3059-1705</orcidid><orcidid>https://orcid.org/0000-0001-8726-185X</orcidid></search><sort><creationdate>20240401</creationdate><title>Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study</title><author>Kochlik, Bastian ; Herpich, Catrin ; Moreno-Villanueva, María ; Klaus, Susanne ; Müller-Werdan, Ursula ; Weinberger, Birgit ; Fiegl, Simone ; Toussaint, Olivier ; Debacq-Chainiaux, Florence ; Schön, Christiane ; Bernhard, Jürgen ; Breusing, Nicolle ; Gonos, Efstathios S. ; Franceschi, Claudio ; Capri, Miriam ; Sikora, Ewa ; Hervonen, Antti ; Hurme, Mikko ; Slagboom, P. Eline ; Dollé, Martijn E. T. ; Jansen, Eugene ; Grune, Tilman ; Bürkle, Alexander ; Norman, Kristina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-c3ffc5456e57fc64996fdcb01f637f629b48af5769aa14782f2d658035bded283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Age</topic><topic>Aged</topic><topic>Aging</topic><topic>Biomedical and Life Sciences</topic><topic>C-Reactive Protein</topic><topic>Cell Biology</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Comorbidity</topic><topic>Cross-Sectional Studies</topic><topic>Depression - epidemiology</topic><topic>Frail Elderly - psychology</topic><topic>Frailty</topic><topic>Geriatrics/Gerontology</topic><topic>Growth Differentiation Factor 15</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Mental depression</topic><topic>Molecular Medicine</topic><topic>Older people</topic><topic>Original</topic><topic>Original Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kochlik, Bastian</creatorcontrib><creatorcontrib>Herpich, Catrin</creatorcontrib><creatorcontrib>Moreno-Villanueva, María</creatorcontrib><creatorcontrib>Klaus, Susanne</creatorcontrib><creatorcontrib>Müller-Werdan, Ursula</creatorcontrib><creatorcontrib>Weinberger, Birgit</creatorcontrib><creatorcontrib>Fiegl, Simone</creatorcontrib><creatorcontrib>Toussaint, Olivier</creatorcontrib><creatorcontrib>Debacq-Chainiaux, Florence</creatorcontrib><creatorcontrib>Schön, Christiane</creatorcontrib><creatorcontrib>Bernhard, Jürgen</creatorcontrib><creatorcontrib>Breusing, Nicolle</creatorcontrib><creatorcontrib>Gonos, Efstathios S.</creatorcontrib><creatorcontrib>Franceschi, Claudio</creatorcontrib><creatorcontrib>Capri, Miriam</creatorcontrib><creatorcontrib>Sikora, Ewa</creatorcontrib><creatorcontrib>Hervonen, Antti</creatorcontrib><creatorcontrib>Hurme, Mikko</creatorcontrib><creatorcontrib>Slagboom, P. Eline</creatorcontrib><creatorcontrib>Dollé, Martijn E. T.</creatorcontrib><creatorcontrib>Jansen, Eugene</creatorcontrib><creatorcontrib>Grune, Tilman</creatorcontrib><creatorcontrib>Bürkle, Alexander</creatorcontrib><creatorcontrib>Norman, Kristina</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>GeroScience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kochlik, Bastian</au><au>Herpich, Catrin</au><au>Moreno-Villanueva, María</au><au>Klaus, Susanne</au><au>Müller-Werdan, Ursula</au><au>Weinberger, Birgit</au><au>Fiegl, Simone</au><au>Toussaint, Olivier</au><au>Debacq-Chainiaux, Florence</au><au>Schön, Christiane</au><au>Bernhard, Jürgen</au><au>Breusing, Nicolle</au><au>Gonos, Efstathios S.</au><au>Franceschi, Claudio</au><au>Capri, Miriam</au><au>Sikora, Ewa</au><au>Hervonen, Antti</au><au>Hurme, Mikko</au><au>Slagboom, P. Eline</au><au>Dollé, Martijn E. T.</au><au>Jansen, Eugene</au><au>Grune, Tilman</au><au>Bürkle, Alexander</au><au>Norman, Kristina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study</atitle><jtitle>GeroScience</jtitle><stitle>GeroScience</stitle><addtitle>Geroscience</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>46</volume><issue>2</issue><spage>1657</spage><epage>1669</epage><pages>1657-1669</pages><issn>2509-2723</issn><issn>2509-2715</issn><eissn>2509-2723</eissn><abstract>Growth differentiation factor-15 (GDF15) might be involved in the development of cognitive frailty and depression. Therefore, we evaluated cross-sectional associations of plasma GDF15 with combined cognitive-frailty-and-depression in older (i.e. ≥ 55 years) and younger adults of the MARK-AGE study. In the present work, samples and data of MARK-AGE (“European study to establish bioMARKers of human AGEing“) participants (
N
= 2736) were analyzed. Cognitive frailty was determined by the global cognitive functioning score (GCF) and depression by the Self-Rating Depression Scale (SDS score). Adults were classified into three groups: (I) neither-cognitive-frailty-nor-depression, (II) either-cognitive-frailty-or-depression or (III) both-cognitive-frailty-and-depression. Cross-sectional associations were determined by unadjusted and by age, BMI, sex, comorbidities and hsCRP-adjusted linear and logistic regression analyses. Cognitive frailty, depression, age and GDF15 were significantly related within the whole study sample. High GDF15 levels were significantly associated with both-cognitive-frailty-and-depression (adjusted β = 0.177 [0.044 – 0.310],
p
= 0.009), and with low GCF scores and high SDS scores. High GDF15 concentrations and quartiles were significantly associated with higher odds to have both-cognitive-frailty-and-depression (adjusted odds ratio = 2.353 [1.267 – 4.372],
p
= 0.007; and adjusted odds ratio = 1.414 [1.025 – 1.951],
p
= 0.035, respectively) independent of age, BMI, sex, comorbidities and hsCRP. These associations remained significant when evaluating older adults. We conclude that plasma GDF15 concentrations are significantly associated with combined cognitive-frailty-and-depression status and, with cognitive frailty and depressive symptoms separately in old as well as young community-dwelling adults.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>37715843</pmid><doi>10.1007/s11357-023-00902-6</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-8614-1044</orcidid><orcidid>https://orcid.org/0000-0002-7084-946X</orcidid><orcidid>https://orcid.org/0000-0002-1111-1748</orcidid><orcidid>https://orcid.org/0000-0003-4775-9973</orcidid><orcidid>https://orcid.org/0000-0003-3949-395X</orcidid><orcidid>https://orcid.org/0000-0001-9841-6386</orcidid><orcidid>https://orcid.org/0000-0002-2875-4723</orcidid><orcidid>https://orcid.org/0000-0003-4440-8991</orcidid><orcidid>https://orcid.org/0000-0003-0214-7092</orcidid><orcidid>https://orcid.org/0000-0001-6137-6544</orcidid><orcidid>https://orcid.org/0000-0002-3151-5897</orcidid><orcidid>https://orcid.org/0000-0003-2029-9102</orcidid><orcidid>https://orcid.org/0000-0001-9077-0401</orcidid><orcidid>https://orcid.org/0000-0003-3787-5268</orcidid><orcidid>https://orcid.org/0000-0003-1069-2656</orcidid><orcidid>https://orcid.org/0000-0003-3059-1705</orcidid><orcidid>https://orcid.org/0000-0001-8726-185X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2509-2723 |
| ispartof | GeroScience, 2024-04, Vol.46 (2), p.1657-1669 |
| issn | 2509-2723 2509-2715 2509-2723 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10828354 |
| source | MEDLINE; SpringerLink Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Age Aged Aging Biomedical and Life Sciences C-Reactive Protein Cell Biology Cognition Cognitive ability Comorbidity Cross-Sectional Studies Depression - epidemiology Frail Elderly - psychology Frailty Geriatrics/Gerontology Growth Differentiation Factor 15 Humans Life Sciences Mental depression Molecular Medicine Older people Original Original Article |
| title | Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T03%3A16%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Associations%20of%20circulating%20GDF15%20with%20combined%20cognitive%20frailty%20and%20depression%20in%20older%20adults%20of%20the%20MARK-AGE%20study&rft.jtitle=GeroScience&rft.au=Kochlik,%20Bastian&rft.date=2024-04-01&rft.volume=46&rft.issue=2&rft.spage=1657&rft.epage=1669&rft.pages=1657-1669&rft.issn=2509-2723&rft.eissn=2509-2723&rft_id=info:doi/10.1007/s11357-023-00902-6&rft_dat=%3Cproquest_pubme%3E2920223418%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2920223418&rft_id=info:pmid/37715843&rfr_iscdi=true |