Early life thymectomy induces arterial dysfunction in mice

Aging of the arteries is characterized by increased large artery stiffness and impaired endothelium-dependent dilation. We have previously shown that in old (22-24 month) mice T cells accumulate within aorta and mesentery. We have also shown that pharmacologic and genetic deletion of these T cells a...

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Veröffentlicht in:	GeroScience 2024-02, Vol.46 (1), p.1035-1051
Hauptverfasser:	Buckley, David J., Sharma, Sunita, Joseph, Blessy, Fayyaz, Alia H., Canizales, Alexandra, Terrebonne, Konner J., Trott, Daniel W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Aorta Arteries Bioavailability Biomedical and Life Sciences CD4 antigen CD8 antigen Cell Biology Clonal deletion Coronary vessels Endothelium Geriatrics/Gerontology Immunological memory Inflammation Life Sciences Lymphocytes Lymphocytes T Memory cells Mesentery Mice Molecular Medicine Nitric oxide Original Original Article Phenotypes Thymectomy Thymus Thymus Gland Veins & arteries
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