PEDF protects retinal pigment epithelium from ferroptosis and ameliorates dry AMD-like pathology in a murine model

Age-related macular degeneration (AMD) is the leading cause of irreversible vision damage among elderly individuals. There is still no efficient treatment for dry AMD. Retinal pigment epithelial (RPE) degeneration has been confirmed to play an important role in dry AMD. Recent studies have reported...

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Veröffentlicht in:	GeroScience 2024-04, Vol.46 (2), p.2697-2714
Hauptverfasser:	Xiang, Wei, Li, Longhui, Zhao, Qin, Zeng, Yongcheng, Shi, Jinhui, Chen, Zitong, Gao, Guoquan, Lai, Kunbei
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Animal models Animals Biomedical and Life Sciences Cell Biology Disease Models, Animal Epithelium Eye Proteins Ferritin Ferroptosis Geriatrics/Gerontology Glutathione peroxidase Humans Immunofluorescence Life Sciences Lipid peroxidation Lipids Macular degeneration Mice Mice, Knockout Molecular Medicine Nerve Growth Factors Original Original Article Pathology Pigment epithelium-derived factor Retina Retinal pigment epithelium Retinal Pigment Epithelium - metabolism Retinal Pigment Epithelium - pathology Serpins Therapeutic targets Western blotting
Online-Zugang:	Volltext
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