Preoperative Hypoalbuminemia as a Predictor of Severe Postoperative Complications in Patients Undergoing Whipple Pancreatoduodenectomy
Background: Pancreaticoduodenectomy (PD) known as Whipple procedure is still one of the most complex abdominal surgeries used for treatment of periampullary tumors. PD is often followed with postoperative complications (pancreatic, biliar or intestinal fistula, haemorrhage, intraabdominal abscess, d...
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| Veröffentlicht in: | Medicinski arhiv 2023, Vol.77 (5), p.350-353 |
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| description | Background: Pancreaticoduodenectomy (PD) known as Whipple procedure is still one of the most complex abdominal surgeries used for treatment of periampullary tumors. PD is often followed with postoperative complications (pancreatic, biliar or intestinal fistula, haemorrhage, intraabdominal abscess, delayed gastric empting. Severe postoperative complications (SPC) can be reason for reoperation and reason of bad outcome of treatment and life treathening condition. Objective: To investigate predicitive value of preoperative hypoalbuminemia for severe postoperative complications (SPC) in patients who have undergone Whipple pancreaticoduodenetomy (PD). However, no similiar study has been ever reported from our country until now. Methods: In this retrospective-prospective study, 100 patients who have had Whipple pancreaticoduodenectomy for malignant periampullary tumors at the Department for Surgery of University Clinic Center Tuzla, Bosnia and Herzegovina were enrolled, from january of 2009 to decembre of 2021. All patients were preoperatively analysed according to serum albumine levels and presensce of hypolabuminemia (serum albumine levels |
| doi_str_mv | 10.5455/medarh.2023.77.350-353 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10825745</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2883018217</sourcerecordid><originalsourceid>FETCH-LOGICAL-c234t-813e654c66d3be4f886a01e8f99f34638eaaedb9c90fea947c2e44acdef99aa13</originalsourceid><addsrcrecordid>eNpVUduK2zAQFUsLm-72F4qgz04lS7Klp1JCu1tYaKC7tG9iIo8TLbbkSnYgP9DvrkKWlj4McztzZphDyDvO1koq9WHEDtJhXbNarNt2LRSrhBJXZMWNbiplGv6KrNi5zI35eU3e5PzMmDJtbVbk9zZhnDDB7I9I709ThGG3jD7g6IFCpkALovNujonGnn7HIyak25jnf2ObOE6DdyWJIVMf6LaEGOZMn0KHaR992NMfBz9NQxmF4BLCHLsldhiwMI-nW_K6hyHj2xd_Q56-fH7c3FcP3-6-bj49VK4Wcq40F9go6ZqmEzuUvdYNMI66N6YXshEaAbDbGWdYj2Bk62qUElyHBQHAxQ35eOGdll35mytHJhjslPwI6WQjePt_J_iD3cej5UzXqpWqMLx_YUjx14J5ts9xSaEcbWutBeO65m1BNReUSzHnhP3fFZzZs2r2opo9q2bb1hZ5ignxB2PEk0U</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2883018217</pqid></control><display><type>article</type><title>Preoperative Hypoalbuminemia as a Predictor of Severe Postoperative Complications in Patients Undergoing Whipple Pancreatoduodenectomy</title><source>Electronic Journals Library</source><source>PubMed Central(OpenAccess)</source><source>PubMed Central Open Access</source><creator>Ahmetasevic, Emir ; Hasukic, Sefik ; Agic, Mirha ; Brkic, Selmira</creator><creatorcontrib>Ahmetasevic, Emir ; Hasukic, Sefik ; Agic, Mirha ; Brkic, Selmira</creatorcontrib><description>Background: Pancreaticoduodenectomy (PD) known as Whipple procedure is still one of the most complex abdominal surgeries used for treatment of periampullary tumors. PD is often followed with postoperative complications (pancreatic, biliar or intestinal fistula, haemorrhage, intraabdominal abscess, delayed gastric empting. Severe postoperative complications (SPC) can be reason for reoperation and reason of bad outcome of treatment and life treathening condition. Objective: To investigate predicitive value of preoperative hypoalbuminemia for severe postoperative complications (SPC) in patients who have undergone Whipple pancreaticoduodenetomy (PD). However, no similiar study has been ever reported from our country until now. Methods: In this retrospective-prospective study, 100 patients who have had Whipple pancreaticoduodenectomy for malignant periampullary tumors at the Department for Surgery of University Clinic Center Tuzla, Bosnia and Herzegovina were enrolled, from january of 2009 to decembre of 2021. All patients were preoperatively analysed according to serum albumine levels and presensce of hypolabuminemia (serum albumine levels <32g/l). Serum albumine biochemical test were done 1-2 days preoperatively. Clavien Dindo classification was used for determination patients with SPC. Patients who did not have SPC belonged to (I-II) Clavien Dindo group of patients while those who had SPC belonged to( III-V) Clavien Dindo group of patients. Results: Out of 100 patients who have undergone pancreaticoduodenetomy, in 55 (55%) patients postoperative complications were noticed. Mortality rate was 18 (18%) and reoperation has been done in 20 cases (20%). SPC were noticed in 19 patients and most often were: delayed gastric emptying (20%), pancreatic fistula (13%) and intraabdominal collections (9%). Hypoalbuminemic patients had a significantly higher rate of severe postoperative complications ( p<0.05). Using hypoalbuminemia-SPC correlation analaysis, there is confirmed statistically significant correlation between hypoalbuminemia and SPC (ρ= 0.236; p<0.05). Conclusion: Preoperative hypoalbuminemia can be used as predictor and prognostic factor for severe postoperative complications after Whipple pancreaticoduodenectomy. Identification and optimization of serum albumin level prior to Whipple pancreatoduodenectomy may improve surgical outcomes.</description><identifier>ISSN: 0350-199X</identifier><identifier>EISSN: 1986-5961</identifier><identifier>DOI: 10.5455/medarh.2023.77.350-353</identifier><language>eng</language><publisher>Sarajevo: Academy of Medical Sciences of Bosnia and Herzegovina</publisher><subject>Abdominal surgery ; Abscesses ; Conflicts of interest ; Fistula ; Hemorrhage ; Metastasis ; Morbidity ; Mortality ; Original Paper ; Pancreaticoduodenectomy ; Statistical analysis ; Surgical outcomes ; Tumors</subject><ispartof>Medicinski arhiv, 2023, Vol.77 (5), p.350-353</ispartof><rights>Copyright Academy of Medical Sciences of Bosnia and Herzegovina 2023</rights><rights>2023 Emir Ahmetasevic, Sefik Hasukic, Mirha Agic, Selmira Brkic 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10825745/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10825745/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Ahmetasevic, Emir</creatorcontrib><creatorcontrib>Hasukic, Sefik</creatorcontrib><creatorcontrib>Agic, Mirha</creatorcontrib><creatorcontrib>Brkic, Selmira</creatorcontrib><title>Preoperative Hypoalbuminemia as a Predictor of Severe Postoperative Complications in Patients Undergoing Whipple Pancreatoduodenectomy</title><title>Medicinski arhiv</title><description>Background: Pancreaticoduodenectomy (PD) known as Whipple procedure is still one of the most complex abdominal surgeries used for treatment of periampullary tumors. PD is often followed with postoperative complications (pancreatic, biliar or intestinal fistula, haemorrhage, intraabdominal abscess, delayed gastric empting. Severe postoperative complications (SPC) can be reason for reoperation and reason of bad outcome of treatment and life treathening condition. Objective: To investigate predicitive value of preoperative hypoalbuminemia for severe postoperative complications (SPC) in patients who have undergone Whipple pancreaticoduodenetomy (PD). However, no similiar study has been ever reported from our country until now. Methods: In this retrospective-prospective study, 100 patients who have had Whipple pancreaticoduodenectomy for malignant periampullary tumors at the Department for Surgery of University Clinic Center Tuzla, Bosnia and Herzegovina were enrolled, from january of 2009 to decembre of 2021. All patients were preoperatively analysed according to serum albumine levels and presensce of hypolabuminemia (serum albumine levels <32g/l). Serum albumine biochemical test were done 1-2 days preoperatively. Clavien Dindo classification was used for determination patients with SPC. Patients who did not have SPC belonged to (I-II) Clavien Dindo group of patients while those who had SPC belonged to( III-V) Clavien Dindo group of patients. Results: Out of 100 patients who have undergone pancreaticoduodenetomy, in 55 (55%) patients postoperative complications were noticed. Mortality rate was 18 (18%) and reoperation has been done in 20 cases (20%). SPC were noticed in 19 patients and most often were: delayed gastric emptying (20%), pancreatic fistula (13%) and intraabdominal collections (9%). Hypoalbuminemic patients had a significantly higher rate of severe postoperative complications ( p<0.05). Using hypoalbuminemia-SPC correlation analaysis, there is confirmed statistically significant correlation between hypoalbuminemia and SPC (ρ= 0.236; p<0.05). Conclusion: Preoperative hypoalbuminemia can be used as predictor and prognostic factor for severe postoperative complications after Whipple pancreaticoduodenectomy. Identification and optimization of serum albumin level prior to Whipple pancreatoduodenectomy may improve surgical outcomes.</description><subject>Abdominal surgery</subject><subject>Abscesses</subject><subject>Conflicts of interest</subject><subject>Fistula</subject><subject>Hemorrhage</subject><subject>Metastasis</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Original Paper</subject><subject>Pancreaticoduodenectomy</subject><subject>Statistical analysis</subject><subject>Surgical outcomes</subject><subject>Tumors</subject><issn>0350-199X</issn><issn>1986-5961</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpVUduK2zAQFUsLm-72F4qgz04lS7Klp1JCu1tYaKC7tG9iIo8TLbbkSnYgP9DvrkKWlj4McztzZphDyDvO1koq9WHEDtJhXbNarNt2LRSrhBJXZMWNbiplGv6KrNi5zI35eU3e5PzMmDJtbVbk9zZhnDDB7I9I709ThGG3jD7g6IFCpkALovNujonGnn7HIyak25jnf2ObOE6DdyWJIVMf6LaEGOZMn0KHaR992NMfBz9NQxmF4BLCHLsldhiwMI-nW_K6hyHj2xd_Q56-fH7c3FcP3-6-bj49VK4Wcq40F9go6ZqmEzuUvdYNMI66N6YXshEaAbDbGWdYj2Bk62qUElyHBQHAxQ35eOGdll35mytHJhjslPwI6WQjePt_J_iD3cej5UzXqpWqMLx_YUjx14J5ts9xSaEcbWutBeO65m1BNReUSzHnhP3fFZzZs2r2opo9q2bb1hZ5ignxB2PEk0U</recordid><startdate>2023</startdate><enddate>2023</enddate><creator>Ahmetasevic, Emir</creator><creator>Hasukic, Sefik</creator><creator>Agic, Mirha</creator><creator>Brkic, Selmira</creator><general>Academy of Medical Sciences of Bosnia and Herzegovina</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>2023</creationdate><title>Preoperative Hypoalbuminemia as a Predictor of Severe Postoperative Complications in Patients Undergoing Whipple Pancreatoduodenectomy</title><author>Ahmetasevic, Emir ; Hasukic, Sefik ; Agic, Mirha ; Brkic, Selmira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c234t-813e654c66d3be4f886a01e8f99f34638eaaedb9c90fea947c2e44acdef99aa13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Abdominal surgery</topic><topic>Abscesses</topic><topic>Conflicts of interest</topic><topic>Fistula</topic><topic>Hemorrhage</topic><topic>Metastasis</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Original Paper</topic><topic>Pancreaticoduodenectomy</topic><topic>Statistical analysis</topic><topic>Surgical outcomes</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmetasevic, Emir</creatorcontrib><creatorcontrib>Hasukic, Sefik</creatorcontrib><creatorcontrib>Agic, Mirha</creatorcontrib><creatorcontrib>Brkic, Selmira</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicinski arhiv</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmetasevic, Emir</au><au>Hasukic, Sefik</au><au>Agic, Mirha</au><au>Brkic, Selmira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoperative Hypoalbuminemia as a Predictor of Severe Postoperative Complications in Patients Undergoing Whipple Pancreatoduodenectomy</atitle><jtitle>Medicinski arhiv</jtitle><date>2023</date><risdate>2023</risdate><volume>77</volume><issue>5</issue><spage>350</spage><epage>353</epage><pages>350-353</pages><issn>0350-199X</issn><eissn>1986-5961</eissn><abstract>Background: Pancreaticoduodenectomy (PD) known as Whipple procedure is still one of the most complex abdominal surgeries used for treatment of periampullary tumors. PD is often followed with postoperative complications (pancreatic, biliar or intestinal fistula, haemorrhage, intraabdominal abscess, delayed gastric empting. Severe postoperative complications (SPC) can be reason for reoperation and reason of bad outcome of treatment and life treathening condition. Objective: To investigate predicitive value of preoperative hypoalbuminemia for severe postoperative complications (SPC) in patients who have undergone Whipple pancreaticoduodenetomy (PD). However, no similiar study has been ever reported from our country until now. Methods: In this retrospective-prospective study, 100 patients who have had Whipple pancreaticoduodenectomy for malignant periampullary tumors at the Department for Surgery of University Clinic Center Tuzla, Bosnia and Herzegovina were enrolled, from january of 2009 to decembre of 2021. All patients were preoperatively analysed according to serum albumine levels and presensce of hypolabuminemia (serum albumine levels <32g/l). Serum albumine biochemical test were done 1-2 days preoperatively. Clavien Dindo classification was used for determination patients with SPC. Patients who did not have SPC belonged to (I-II) Clavien Dindo group of patients while those who had SPC belonged to( III-V) Clavien Dindo group of patients. Results: Out of 100 patients who have undergone pancreaticoduodenetomy, in 55 (55%) patients postoperative complications were noticed. Mortality rate was 18 (18%) and reoperation has been done in 20 cases (20%). SPC were noticed in 19 patients and most often were: delayed gastric emptying (20%), pancreatic fistula (13%) and intraabdominal collections (9%). Hypoalbuminemic patients had a significantly higher rate of severe postoperative complications ( p<0.05). Using hypoalbuminemia-SPC correlation analaysis, there is confirmed statistically significant correlation between hypoalbuminemia and SPC (ρ= 0.236; p<0.05). Conclusion: Preoperative hypoalbuminemia can be used as predictor and prognostic factor for severe postoperative complications after Whipple pancreaticoduodenectomy. Identification and optimization of serum albumin level prior to Whipple pancreatoduodenectomy may improve surgical outcomes.</abstract><cop>Sarajevo</cop><pub>Academy of Medical Sciences of Bosnia and Herzegovina</pub><doi>10.5455/medarh.2023.77.350-353</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abdominal surgery Abscesses Conflicts of interest Fistula Hemorrhage Metastasis Morbidity Mortality Original Paper Pancreaticoduodenectomy Statistical analysis Surgical outcomes Tumors |
| title | Preoperative Hypoalbuminemia as a Predictor of Severe Postoperative Complications in Patients Undergoing Whipple Pancreatoduodenectomy |
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