T‐cell receptor sequencing reveals hepatocellular carcinoma immune characteristics according to Barcelona Clinic liver cancer stages within liver tissue and peripheral blood
Analysis of T‐cell receptor (TCR) repertoires in different stages of hepatocellular carcinoma (HCC) might help to elucidate its pathogenesis and progression. This study aimed to investigate TCR profiles in liver biopsies and peripheral blood mononuclear cells (PBMCs) in different Barcelona Clinic li...
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| Veröffentlicht in: | Cancer science 2024-01, Vol.115 (1), p.94-108 |
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| creator | Li, Rui Wang, Junxiao Li, Xiubin Liang, Yining Jiang, Yiyun Zhang, Yuwei Xu, Pengfei Deng, Ling Wang, Zhe Sun, Tao Wu, Jian Xie, Hui Wang, Yijin |
| description | Analysis of T‐cell receptor (TCR) repertoires in different stages of hepatocellular carcinoma (HCC) might help to elucidate its pathogenesis and progression. This study aimed to investigate TCR profiles in liver biopsies and peripheral blood mononuclear cells (PBMCs) in different Barcelona Clinic liver cancer (BCLC) stages of HCC. Ten patients in early stage (BCLC_A), 10 patients in middle stage (BCLC_B), and 10 patients in late stage (BCLC_C) cancer were prospectively enrolled. The liver tumor tissues, adjacent tissues, and PBMCs of each patient were collected and examined by TCR β sequencing. Based on the ImMunoGeneTics (IMGT) database, we aligned the V, D, J, and C gene segments and identified the frequency of CDR3 sequences and amino acids sequence. Diversity of TCR in PBMCs was higher than in both tumor tissues and adjacent tissues, regardless of BCLC stage and postoperative recurrence. TCR clonality was increased in T cells from peripheral blood in advanced HCC, compared with the early and middle stages. No statistical differences were observed between different BCLC stages, either in tumors or adjacent tissues. TCR clonality revealed no significant difference between recurrent tumor and non‐recurrent tumor, therefore PBMCs was better to be representative of TCR characteristics in different stages of HCC compared to tumor tissues. Clonal expansion of T cells was associated with low risk of recurrence in HCC patients.
T‐cell receptor (TCR) clonality was increased in T cells from peripheral blood in advanced hepatocellular carcinoma (HCC), compared with the early and middle stages. Peripheral blood mononuclear cells (PBMCs) was better to be representative of TCR characteristics in different stages of HCC compared to tumor tissues. Clonal expansion of T cells was associated with low risk of recurrence in HCC patients. |
| doi_str_mv | 10.1111/cas.16013 |
| format | Article |
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T‐cell receptor (TCR) clonality was increased in T cells from peripheral blood in advanced hepatocellular carcinoma (HCC), compared with the early and middle stages. Peripheral blood mononuclear cells (PBMCs) was better to be representative of TCR characteristics in different stages of HCC compared to tumor tissues. Clonal expansion of T cells was associated with low risk of recurrence in HCC patients.</description><identifier>ISSN: 1347-9032</identifier><identifier>ISSN: 1349-7006</identifier><identifier>EISSN: 1349-7006</identifier><identifier>DOI: 10.1111/cas.16013</identifier><identifier>PMID: 37962061</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Ablation ; Amino acids ; Biopsy ; C gene ; Carcinoma, Hepatocellular - pathology ; clonal expansion ; Complementarity-determining region 3 ; HCC stages ; Hepatocellular carcinoma ; Humans ; Leukocytes (mononuclear) ; Leukocytes, Mononuclear - pathology ; Liver cancer ; Liver Neoplasms - pathology ; Lymphocytes ; Lymphocytes T ; Medical prognosis ; Neoplasm Recurrence, Local - genetics ; Neoplasm Recurrence, Local - pathology ; Neoplasm Staging ; Original ; Peripheral blood mononuclear cells ; Receptors, Antigen, T-Cell - genetics ; recurrent tumor ; Retrospective Studies ; Software ; T cell receptors ; TCR sequencing ; Treatment Outcome ; Tumors</subject><ispartof>Cancer science, 2024-01, Vol.115 (1), p.94-108</ispartof><rights>2023 The Authors. published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.</rights><rights>2023 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4043-500c6d139dc925062ed459b3c2173e2b83ccb85ab7f05e6f2fb5f2888558f1dd3</cites><orcidid>0000-0002-3700-1766 ; 0000-0003-4322-7267</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10823291/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10823291/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37962061$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Rui</creatorcontrib><creatorcontrib>Wang, Junxiao</creatorcontrib><creatorcontrib>Li, Xiubin</creatorcontrib><creatorcontrib>Liang, Yining</creatorcontrib><creatorcontrib>Jiang, Yiyun</creatorcontrib><creatorcontrib>Zhang, Yuwei</creatorcontrib><creatorcontrib>Xu, Pengfei</creatorcontrib><creatorcontrib>Deng, Ling</creatorcontrib><creatorcontrib>Wang, Zhe</creatorcontrib><creatorcontrib>Sun, Tao</creatorcontrib><creatorcontrib>Wu, Jian</creatorcontrib><creatorcontrib>Xie, Hui</creatorcontrib><creatorcontrib>Wang, Yijin</creatorcontrib><title>T‐cell receptor sequencing reveals hepatocellular carcinoma immune characteristics according to Barcelona Clinic liver cancer stages within liver tissue and peripheral blood</title><title>Cancer science</title><addtitle>Cancer Sci</addtitle><description>Analysis of T‐cell receptor (TCR) repertoires in different stages of hepatocellular carcinoma (HCC) might help to elucidate its pathogenesis and progression. This study aimed to investigate TCR profiles in liver biopsies and peripheral blood mononuclear cells (PBMCs) in different Barcelona Clinic liver cancer (BCLC) stages of HCC. Ten patients in early stage (BCLC_A), 10 patients in middle stage (BCLC_B), and 10 patients in late stage (BCLC_C) cancer were prospectively enrolled. The liver tumor tissues, adjacent tissues, and PBMCs of each patient were collected and examined by TCR β sequencing. Based on the ImMunoGeneTics (IMGT) database, we aligned the V, D, J, and C gene segments and identified the frequency of CDR3 sequences and amino acids sequence. Diversity of TCR in PBMCs was higher than in both tumor tissues and adjacent tissues, regardless of BCLC stage and postoperative recurrence. TCR clonality was increased in T cells from peripheral blood in advanced HCC, compared with the early and middle stages. No statistical differences were observed between different BCLC stages, either in tumors or adjacent tissues. TCR clonality revealed no significant difference between recurrent tumor and non‐recurrent tumor, therefore PBMCs was better to be representative of TCR characteristics in different stages of HCC compared to tumor tissues. Clonal expansion of T cells was associated with low risk of recurrence in HCC patients.
T‐cell receptor (TCR) clonality was increased in T cells from peripheral blood in advanced hepatocellular carcinoma (HCC), compared with the early and middle stages. Peripheral blood mononuclear cells (PBMCs) was better to be representative of TCR characteristics in different stages of HCC compared to tumor tissues. Clonal expansion of T cells was associated with low risk of recurrence in HCC patients.</description><subject>Ablation</subject><subject>Amino acids</subject><subject>Biopsy</subject><subject>C gene</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>clonal expansion</subject><subject>Complementarity-determining region 3</subject><subject>HCC stages</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Leukocytes (mononuclear)</subject><subject>Leukocytes, Mononuclear - pathology</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - pathology</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Medical prognosis</subject><subject>Neoplasm Recurrence, Local - genetics</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Staging</subject><subject>Original</subject><subject>Peripheral blood mononuclear cells</subject><subject>Receptors, Antigen, T-Cell - genetics</subject><subject>recurrent tumor</subject><subject>Retrospective Studies</subject><subject>Software</subject><subject>T cell receptors</subject><subject>TCR sequencing</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>1347-9032</issn><issn>1349-7006</issn><issn>1349-7006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kktu1TAUhiMEoqUwYAPIEhMYpPUjL49Qe8VLqsSAMrack5MbV4kdbOdWnbEEdsKeWAlO76UCJDyx5fPp82_7ZNlzRk9ZGmegwymrKBMPsmMmCpnXlFYP79Z1LqngR9mTEK4pFVUhi8fZkahlxWnFjrMfVz-_fQccR-IRcI7Ok4BfF7Rg7Dbt7VCPgQw46-hWbBm1J6B9KrtJEzNNi0UCg_YaInoTooFANIDz3WqIjlwkGkdnNdmMxhogo9nhKrGQphD1FgO5MXEw9lCKJoQFibYdmZNzHtDrkbSjc93T7FGfEuGzw3ySfXn39mrzIb_89P7j5vwyh4IWIi8phapjQnYgeUkrjl1RylYAZ7VA3jYCoG1K3dY9LbHqed-WPW-apiybnnWdOMne7L3z0k7YAdqYMqjZm0n7W-W0UX9XrBnU1u0Uow0XXLJkeHUweJceNEQ1mbA-obbolqDSaVLKMsVL6Mt_0Gu3eJvup5JJ8qLgVCbq9Z4C70Lw2N-nYVStfaBSH6i7Pkjsiz_j35O_Pz4BZ3vgxox4-3-T2px_3it_ATKawsE</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Li, Rui</creator><creator>Wang, Junxiao</creator><creator>Li, Xiubin</creator><creator>Liang, Yining</creator><creator>Jiang, Yiyun</creator><creator>Zhang, Yuwei</creator><creator>Xu, Pengfei</creator><creator>Deng, Ling</creator><creator>Wang, Zhe</creator><creator>Sun, Tao</creator><creator>Wu, Jian</creator><creator>Xie, Hui</creator><creator>Wang, Yijin</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3700-1766</orcidid><orcidid>https://orcid.org/0000-0003-4322-7267</orcidid></search><sort><creationdate>202401</creationdate><title>T‐cell receptor sequencing reveals hepatocellular carcinoma immune characteristics according to Barcelona Clinic liver cancer stages within liver tissue and peripheral blood</title><author>Li, Rui ; Wang, Junxiao ; Li, Xiubin ; Liang, Yining ; Jiang, Yiyun ; Zhang, Yuwei ; Xu, Pengfei ; Deng, Ling ; Wang, Zhe ; Sun, Tao ; Wu, Jian ; Xie, Hui ; Wang, Yijin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4043-500c6d139dc925062ed459b3c2173e2b83ccb85ab7f05e6f2fb5f2888558f1dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Ablation</topic><topic>Amino acids</topic><topic>Biopsy</topic><topic>C gene</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>clonal expansion</topic><topic>Complementarity-determining region 3</topic><topic>HCC stages</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Leukocytes (mononuclear)</topic><topic>Leukocytes, Mononuclear - pathology</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - pathology</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Medical prognosis</topic><topic>Neoplasm Recurrence, Local - genetics</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Staging</topic><topic>Original</topic><topic>Peripheral blood mononuclear cells</topic><topic>Receptors, Antigen, T-Cell - genetics</topic><topic>recurrent tumor</topic><topic>Retrospective Studies</topic><topic>Software</topic><topic>T cell receptors</topic><topic>TCR sequencing</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Rui</creatorcontrib><creatorcontrib>Wang, Junxiao</creatorcontrib><creatorcontrib>Li, Xiubin</creatorcontrib><creatorcontrib>Liang, Yining</creatorcontrib><creatorcontrib>Jiang, Yiyun</creatorcontrib><creatorcontrib>Zhang, Yuwei</creatorcontrib><creatorcontrib>Xu, Pengfei</creatorcontrib><creatorcontrib>Deng, Ling</creatorcontrib><creatorcontrib>Wang, Zhe</creatorcontrib><creatorcontrib>Sun, Tao</creatorcontrib><creatorcontrib>Wu, Jian</creatorcontrib><creatorcontrib>Xie, Hui</creatorcontrib><creatorcontrib>Wang, Yijin</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Rui</au><au>Wang, Junxiao</au><au>Li, Xiubin</au><au>Liang, Yining</au><au>Jiang, Yiyun</au><au>Zhang, Yuwei</au><au>Xu, Pengfei</au><au>Deng, Ling</au><au>Wang, Zhe</au><au>Sun, Tao</au><au>Wu, Jian</au><au>Xie, Hui</au><au>Wang, Yijin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T‐cell receptor sequencing reveals hepatocellular carcinoma immune characteristics according to Barcelona Clinic liver cancer stages within liver tissue and peripheral blood</atitle><jtitle>Cancer science</jtitle><addtitle>Cancer Sci</addtitle><date>2024-01</date><risdate>2024</risdate><volume>115</volume><issue>1</issue><spage>94</spage><epage>108</epage><pages>94-108</pages><issn>1347-9032</issn><issn>1349-7006</issn><eissn>1349-7006</eissn><abstract>Analysis of T‐cell receptor (TCR) repertoires in different stages of hepatocellular carcinoma (HCC) might help to elucidate its pathogenesis and progression. This study aimed to investigate TCR profiles in liver biopsies and peripheral blood mononuclear cells (PBMCs) in different Barcelona Clinic liver cancer (BCLC) stages of HCC. Ten patients in early stage (BCLC_A), 10 patients in middle stage (BCLC_B), and 10 patients in late stage (BCLC_C) cancer were prospectively enrolled. The liver tumor tissues, adjacent tissues, and PBMCs of each patient were collected and examined by TCR β sequencing. Based on the ImMunoGeneTics (IMGT) database, we aligned the V, D, J, and C gene segments and identified the frequency of CDR3 sequences and amino acids sequence. Diversity of TCR in PBMCs was higher than in both tumor tissues and adjacent tissues, regardless of BCLC stage and postoperative recurrence. TCR clonality was increased in T cells from peripheral blood in advanced HCC, compared with the early and middle stages. No statistical differences were observed between different BCLC stages, either in tumors or adjacent tissues. TCR clonality revealed no significant difference between recurrent tumor and non‐recurrent tumor, therefore PBMCs was better to be representative of TCR characteristics in different stages of HCC compared to tumor tissues. Clonal expansion of T cells was associated with low risk of recurrence in HCC patients.
T‐cell receptor (TCR) clonality was increased in T cells from peripheral blood in advanced hepatocellular carcinoma (HCC), compared with the early and middle stages. Peripheral blood mononuclear cells (PBMCs) was better to be representative of TCR characteristics in different stages of HCC compared to tumor tissues. Clonal expansion of T cells was associated with low risk of recurrence in HCC patients.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>37962061</pmid><doi>10.1111/cas.16013</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-3700-1766</orcidid><orcidid>https://orcid.org/0000-0003-4322-7267</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Ablation Amino acids Biopsy C gene Carcinoma, Hepatocellular - pathology clonal expansion Complementarity-determining region 3 HCC stages Hepatocellular carcinoma Humans Leukocytes (mononuclear) Leukocytes, Mononuclear - pathology Liver cancer Liver Neoplasms - pathology Lymphocytes Lymphocytes T Medical prognosis Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Neoplasm Staging Original Peripheral blood mononuclear cells Receptors, Antigen, T-Cell - genetics recurrent tumor Retrospective Studies Software T cell receptors TCR sequencing Treatment Outcome Tumors |
| title | T‐cell receptor sequencing reveals hepatocellular carcinoma immune characteristics according to Barcelona Clinic liver cancer stages within liver tissue and peripheral blood |
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