Sedative and physiologic effects of tiletamine–zolazepam following buccal administration in cats
Objectives The aim of this study was to describe the sedative and some physiological effects of tiletamine–zolazepam following buccal administration (BA) in cats. Methods Seven healthy spayed European shorthair cats (three males, four females) were studied twice in this randomized, blinded, crossove...
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| Veröffentlicht in: | Journal of feline medicine and surgery 2020-02, Vol.22 (2), p.108-113 |
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| creator | Nejamkin, Pablo Cavilla, Verónica Clausse, María Landivar, Florencia Lorenzutti, Augusto M Martínez, Sofía Del Sole, María J Martín-Flores, Manuel |
| description | Objectives
The aim of this study was to describe the sedative and some physiological effects of tiletamine–zolazepam following buccal administration (BA) in cats.
Methods
Seven healthy spayed European shorthair cats (three males, four females) were studied twice in this randomized, blinded, crossover study. Each cat received two doses of tiletamine–zolazepam by BA: the low-dose (LD) group consisted of 5 mg/kg of each drug, and the high-dose (HD) group consisted of 7.5 mg/kg of each. Baseline systolic blood pressure (SAP), heart rate (HR), respiratory rate (RR) and a sedation score were recorded prior to administration of each treatment. The same variables plus the percentage of hemoglobin saturated with oxygen as measured by pulse oximetry (SpO2) were recorded at predefined intervals for the next 2 h.
Results
All cats completed the study. No retching or vomiting were observed. Hypersalivation was observed in 0/7 and 3/7 for LD and HD groups, respectively (P = 0.2). There were significant changes in scores over time for posture, response to clippers and response to manual restraint for both groups, without differences between groups. RR, HR and SAP changed significantly over time. SAP and RR were significantly lower for the HD than for the LD group. No values for hemoglobin saturation |
| doi_str_mv | 10.1177/1098612X19827116 |
| format | Article |
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The aim of this study was to describe the sedative and some physiological effects of tiletamine–zolazepam following buccal administration (BA) in cats.
Methods
Seven healthy spayed European shorthair cats (three males, four females) were studied twice in this randomized, blinded, crossover study. Each cat received two doses of tiletamine–zolazepam by BA: the low-dose (LD) group consisted of 5 mg/kg of each drug, and the high-dose (HD) group consisted of 7.5 mg/kg of each. Baseline systolic blood pressure (SAP), heart rate (HR), respiratory rate (RR) and a sedation score were recorded prior to administration of each treatment. The same variables plus the percentage of hemoglobin saturated with oxygen as measured by pulse oximetry (SpO2) were recorded at predefined intervals for the next 2 h.
Results
All cats completed the study. No retching or vomiting were observed. Hypersalivation was observed in 0/7 and 3/7 for LD and HD groups, respectively (P = 0.2). There were significant changes in scores over time for posture, response to clippers and response to manual restraint for both groups, without differences between groups. RR, HR and SAP changed significantly over time. SAP and RR were significantly lower for the HD than for the LD group. No values for hemoglobin saturation <95% were observed.
Conclusions and relevance
BA of tiletamine–zolazepam at the doses studied here is a simple and effective method for chemical restraint in cats, where the LD group had a lower impact on SAP and RR than the HD group.</description><identifier>ISSN: 1098-612X</identifier><identifier>ISSN: 1532-2750</identifier><identifier>EISSN: 1532-2750</identifier><identifier>DOI: 10.1177/1098612X19827116</identifier><identifier>PMID: 30744474</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Administration, Buccal ; Animals ; Cats ; Conscious Sedation - methods ; Conscious Sedation - veterinary ; Cross-Over Studies ; Drug Combinations ; Female ; females ; heart rate ; Heart Rate - drug effects ; hemoglobin ; Hypnotics and Sedatives - administration & dosage ; Hypnotics and Sedatives - pharmacology ; Male ; males ; Original ; oxygen ; posture ; respiratory rate ; Respiratory Rate - drug effects ; sedation ; sedatives ; spaying ; systolic blood pressure ; Tiletamine - administration & dosage ; Tiletamine - pharmacology ; vomiting ; Zolazepam - administration & dosage ; Zolazepam - pharmacology</subject><ispartof>Journal of feline medicine and surgery, 2020-02, Vol.22 (2), p.108-113</ispartof><rights>The Author(s) 2019</rights><rights>The Author(s) 2019 2019 International Society of Feline Medicine and American Association of Feline Practitioners</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-396249c0cb67bf11b5919fa6de464f0488ef777996f8d0f7e7138f475c3ace5f3</citedby><cites>FETCH-LOGICAL-c426t-396249c0cb67bf11b5919fa6de464f0488ef777996f8d0f7e7138f475c3ace5f3</cites><orcidid>0000-0001-6460-3327</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10814565/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10814565/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,21945,27830,27901,27902,44921,45309,53766,53768</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/1098612X19827116?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30744474$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nejamkin, Pablo</creatorcontrib><creatorcontrib>Cavilla, Verónica</creatorcontrib><creatorcontrib>Clausse, María</creatorcontrib><creatorcontrib>Landivar, Florencia</creatorcontrib><creatorcontrib>Lorenzutti, Augusto M</creatorcontrib><creatorcontrib>Martínez, Sofía</creatorcontrib><creatorcontrib>Del Sole, María J</creatorcontrib><creatorcontrib>Martín-Flores, Manuel</creatorcontrib><title>Sedative and physiologic effects of tiletamine–zolazepam following buccal administration in cats</title><title>Journal of feline medicine and surgery</title><addtitle>J Feline Med Surg</addtitle><description>Objectives
The aim of this study was to describe the sedative and some physiological effects of tiletamine–zolazepam following buccal administration (BA) in cats.
Methods
Seven healthy spayed European shorthair cats (three males, four females) were studied twice in this randomized, blinded, crossover study. Each cat received two doses of tiletamine–zolazepam by BA: the low-dose (LD) group consisted of 5 mg/kg of each drug, and the high-dose (HD) group consisted of 7.5 mg/kg of each. Baseline systolic blood pressure (SAP), heart rate (HR), respiratory rate (RR) and a sedation score were recorded prior to administration of each treatment. The same variables plus the percentage of hemoglobin saturated with oxygen as measured by pulse oximetry (SpO2) were recorded at predefined intervals for the next 2 h.
Results
All cats completed the study. No retching or vomiting were observed. Hypersalivation was observed in 0/7 and 3/7 for LD and HD groups, respectively (P = 0.2). There were significant changes in scores over time for posture, response to clippers and response to manual restraint for both groups, without differences between groups. RR, HR and SAP changed significantly over time. SAP and RR were significantly lower for the HD than for the LD group. No values for hemoglobin saturation <95% were observed.
Conclusions and relevance
BA of tiletamine–zolazepam at the doses studied here is a simple and effective method for chemical restraint in cats, where the LD group had a lower impact on SAP and RR than the HD group.</description><subject>Administration, Buccal</subject><subject>Animals</subject><subject>Cats</subject><subject>Conscious Sedation - methods</subject><subject>Conscious Sedation - veterinary</subject><subject>Cross-Over Studies</subject><subject>Drug Combinations</subject><subject>Female</subject><subject>females</subject><subject>heart rate</subject><subject>Heart Rate - drug effects</subject><subject>hemoglobin</subject><subject>Hypnotics and Sedatives - administration & dosage</subject><subject>Hypnotics and Sedatives - pharmacology</subject><subject>Male</subject><subject>males</subject><subject>Original</subject><subject>oxygen</subject><subject>posture</subject><subject>respiratory rate</subject><subject>Respiratory Rate - drug effects</subject><subject>sedation</subject><subject>sedatives</subject><subject>spaying</subject><subject>systolic blood pressure</subject><subject>Tiletamine - administration & dosage</subject><subject>Tiletamine - pharmacology</subject><subject>vomiting</subject><subject>Zolazepam - administration & dosage</subject><subject>Zolazepam - pharmacology</subject><issn>1098-612X</issn><issn>1532-2750</issn><issn>1532-2750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFTEUhoNY7IfuXUmWbqbN1ySTlUjRWih0UQV3IZM5uU3JJNfJTKVd-R_6D_0lzeXW0gri6hx4n_NyznkRekvJIaVKHVGiO0nZd6o7piiVL9AebTlrmGrJy9pXudnou2i_lCtCiOaavUK7nCghhBJ7qL-Awc7hGrBNA15f3pSQY14Fh8F7cHPB2eM5RJjtGBL8_nV3m6O9hbUdsc8x5p8hrXC_OGcjtkNlQpmn6pgTDgk7O5fXaMfbWODNQz1A3z5_-nr8pTk7Pzk9_njWOMHk3HAtmdCOuF6q3lPat5pqb-UAQgpPRNeBV0ppLX03EK9AUd55oVrHrYPW8wP0Yeu7XvoRBgepLhLNegqjnW5MtsE8V1K4NKt8bSjpqGhlWx3ePzhM-ccCZTZjKA5itAnyUgwTfPPAjqv_o4xpSpRmuqJki7oplzKBf1yJErOJ0fwdYx159_SUx4E_uVWg2QLFrsBc5WVK9bX_NrwHaHuoiQ</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Nejamkin, Pablo</creator><creator>Cavilla, Verónica</creator><creator>Clausse, María</creator><creator>Landivar, Florencia</creator><creator>Lorenzutti, Augusto M</creator><creator>Martínez, Sofía</creator><creator>Del Sole, María J</creator><creator>Martín-Flores, Manuel</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6460-3327</orcidid></search><sort><creationdate>20200201</creationdate><title>Sedative and physiologic effects of tiletamine–zolazepam following buccal administration in cats</title><author>Nejamkin, Pablo ; Cavilla, Verónica ; Clausse, María ; Landivar, Florencia ; Lorenzutti, Augusto M ; Martínez, Sofía ; Del Sole, María J ; Martín-Flores, Manuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-396249c0cb67bf11b5919fa6de464f0488ef777996f8d0f7e7138f475c3ace5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Administration, Buccal</topic><topic>Animals</topic><topic>Cats</topic><topic>Conscious Sedation - methods</topic><topic>Conscious Sedation - veterinary</topic><topic>Cross-Over Studies</topic><topic>Drug Combinations</topic><topic>Female</topic><topic>females</topic><topic>heart rate</topic><topic>Heart Rate - drug effects</topic><topic>hemoglobin</topic><topic>Hypnotics and Sedatives - administration & dosage</topic><topic>Hypnotics and Sedatives - pharmacology</topic><topic>Male</topic><topic>males</topic><topic>Original</topic><topic>oxygen</topic><topic>posture</topic><topic>respiratory rate</topic><topic>Respiratory Rate - drug effects</topic><topic>sedation</topic><topic>sedatives</topic><topic>spaying</topic><topic>systolic blood pressure</topic><topic>Tiletamine - administration & dosage</topic><topic>Tiletamine - pharmacology</topic><topic>vomiting</topic><topic>Zolazepam - administration & dosage</topic><topic>Zolazepam - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nejamkin, Pablo</creatorcontrib><creatorcontrib>Cavilla, Verónica</creatorcontrib><creatorcontrib>Clausse, María</creatorcontrib><creatorcontrib>Landivar, Florencia</creatorcontrib><creatorcontrib>Lorenzutti, Augusto M</creatorcontrib><creatorcontrib>Martínez, Sofía</creatorcontrib><creatorcontrib>Del Sole, María J</creatorcontrib><creatorcontrib>Martín-Flores, Manuel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of feline medicine and surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Nejamkin, Pablo</au><au>Cavilla, Verónica</au><au>Clausse, María</au><au>Landivar, Florencia</au><au>Lorenzutti, Augusto M</au><au>Martínez, Sofía</au><au>Del Sole, María J</au><au>Martín-Flores, Manuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sedative and physiologic effects of tiletamine–zolazepam following buccal administration in cats</atitle><jtitle>Journal of feline medicine and surgery</jtitle><addtitle>J Feline Med Surg</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>22</volume><issue>2</issue><spage>108</spage><epage>113</epage><pages>108-113</pages><issn>1098-612X</issn><issn>1532-2750</issn><eissn>1532-2750</eissn><abstract>Objectives
The aim of this study was to describe the sedative and some physiological effects of tiletamine–zolazepam following buccal administration (BA) in cats.
Methods
Seven healthy spayed European shorthair cats (three males, four females) were studied twice in this randomized, blinded, crossover study. Each cat received two doses of tiletamine–zolazepam by BA: the low-dose (LD) group consisted of 5 mg/kg of each drug, and the high-dose (HD) group consisted of 7.5 mg/kg of each. Baseline systolic blood pressure (SAP), heart rate (HR), respiratory rate (RR) and a sedation score were recorded prior to administration of each treatment. The same variables plus the percentage of hemoglobin saturated with oxygen as measured by pulse oximetry (SpO2) were recorded at predefined intervals for the next 2 h.
Results
All cats completed the study. No retching or vomiting were observed. Hypersalivation was observed in 0/7 and 3/7 for LD and HD groups, respectively (P = 0.2). There were significant changes in scores over time for posture, response to clippers and response to manual restraint for both groups, without differences between groups. RR, HR and SAP changed significantly over time. SAP and RR were significantly lower for the HD than for the LD group. No values for hemoglobin saturation <95% were observed.
Conclusions and relevance
BA of tiletamine–zolazepam at the doses studied here is a simple and effective method for chemical restraint in cats, where the LD group had a lower impact on SAP and RR than the HD group.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>30744474</pmid><doi>10.1177/1098612X19827116</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-6460-3327</orcidid></addata></record> |
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| ispartof | Journal of feline medicine and surgery, 2020-02, Vol.22 (2), p.108-113 |
| issn | 1098-612X 1532-2750 1532-2750 |
| language | eng |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Administration, Buccal Animals Cats Conscious Sedation - methods Conscious Sedation - veterinary Cross-Over Studies Drug Combinations Female females heart rate Heart Rate - drug effects hemoglobin Hypnotics and Sedatives - administration & dosage Hypnotics and Sedatives - pharmacology Male males Original oxygen posture respiratory rate Respiratory Rate - drug effects sedation sedatives spaying systolic blood pressure Tiletamine - administration & dosage Tiletamine - pharmacology vomiting Zolazepam - administration & dosage Zolazepam - pharmacology |
| title | Sedative and physiologic effects of tiletamine–zolazepam following buccal administration in cats |
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