Prevalence of iatrogenic hypothyroidism in hyperthyroid cats treated with radioiodine using an individualised scoring system
Objectives The aim of this study was to report the prevalence of iatrogenic hypothyroidism, with or without azotaemia, based on the measurement of serum total thyroxine (T4), thyroid-stimulating hormone (TSH) and creatinine concentrations, in hyperthyroid cats undergoing radioiodine (131I) treatment...
Gespeichert in:
| Veröffentlicht in: | Journal of feline medicine and surgery 2019-12, Vol.21 (12), p.1149-1156 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1156 |
|---|---|
| container_issue | 12 |
| container_start_page | 1149 |
| container_title | Journal of feline medicine and surgery |
| container_volume | 21 |
| creator | Fernandez, Yordan Puig, Jordi Powell, Roger Seth, Mayank |
| description | Objectives
The aim of this study was to report the prevalence of iatrogenic hypothyroidism, with or without azotaemia, based on the measurement of serum total thyroxine (T4), thyroid-stimulating hormone (TSH) and creatinine concentrations, in hyperthyroid cats undergoing radioiodine (131I) treatment where the 131I dose was calculated using a previously described scoring system. A secondary aim of the study was to determine the positive and negative predictive values of serum T4 and TSH concentrations obtained 19 days after treatment in order to predict the development of iatrogenic hypothyroidism 6–9 months after 131I treatment.
Methods
Serum T4, TSH and creatinine concentrations were measured 19 days and 6–9 months after 131I treatment. The prevalence of iatrogenic hypothyroidism was assessed with the results obtained 6–9 months after 131I treatment.
Results
The prevalence of overt and subclinical hypothyroidism 6–9 months after 131I treatment was 40.0% (22/55 cats) and 12.7% (7/55 cats). Overt hypothyroidism with azotaemia was diagnosed in 8/55 (14.5%) cats. The positive and negative predictive values for the prediction of the development of iatrogenic hypothyroidism 6–9 months after 131I treatment were 72.2% and 80.0%, respectively, for a low serum T4 concentration, and 75.0% and 44.6%, respectively, for an increased serum TSH concentration.
Conclusions and relevance
The use of an individualised scoring system is effective in determining the 131I dose for the treatment of hyperthyroid cats. However, the prevalence of overt hypothyroidism was higher in comparison with other studies using different dosing protocols. Further studies comparing the efficacy of individualised scoring systems and different fixed doses to determine which method is superior are warranted. |
| doi_str_mv | 10.1177/1098612X18822396 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_AFRWT</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10814268</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1098612X18822396</sage_id><sourcerecordid>2179392589</sourcerecordid><originalsourceid>FETCH-LOGICAL-c393t-f74bc259f35f53449712c48f987ecdacd777d6d90b8ff578aff70076ad8fc0ce3</originalsourceid><addsrcrecordid>eNp1kUuLFDEUhYMozji6dyVZuinNo6qSrESG8QEDulBwF9LJTXeGqqRNUi0N_nhTdDuo4Crhnu-chHsQek7JK0qFeE2JkiNl36iUjHE1PkCXdOCsY2IgD9u9yd2qX6AnpdwRQhRX7DG64GQcBZPiEv38nOFgJogWcPI4mJrTFmKweHfcp7o75hRcKDMOcZ1APo-wNbXgmsFUcPhHqDucjQspJBci4KWEuMUmNpsLh-AWM4XSwGJTXpVyLBXmp-iRN1OBZ-fzCn19d_Pl-kN3--n9x-u3t53litfOi35j2aA8H_zA-14JymwvvZICrDPWCSHc6BTZSO8HIY33ghAxGie9JRb4FXpzyt0vmxmchVizmfQ-h9nko04m6L-VGHZ6mw6aEkl7NsqW8PKckNP3BUrVcygWpslESEvRjIp1tYNUDSUn1OZUSgZ__w4lem1N_9tas7z483_3ht81NaA7AcVsQd-lJce2r_8H_gLIRqUl</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2179392589</pqid></control><display><type>article</type><title>Prevalence of iatrogenic hypothyroidism in hyperthyroid cats treated with radioiodine using an individualised scoring system</title><source>Sage Journals GOLD Open Access 2024</source><creator>Fernandez, Yordan ; Puig, Jordi ; Powell, Roger ; Seth, Mayank</creator><creatorcontrib>Fernandez, Yordan ; Puig, Jordi ; Powell, Roger ; Seth, Mayank</creatorcontrib><description>Objectives
The aim of this study was to report the prevalence of iatrogenic hypothyroidism, with or without azotaemia, based on the measurement of serum total thyroxine (T4), thyroid-stimulating hormone (TSH) and creatinine concentrations, in hyperthyroid cats undergoing radioiodine (131I) treatment where the 131I dose was calculated using a previously described scoring system. A secondary aim of the study was to determine the positive and negative predictive values of serum T4 and TSH concentrations obtained 19 days after treatment in order to predict the development of iatrogenic hypothyroidism 6–9 months after 131I treatment.
Methods
Serum T4, TSH and creatinine concentrations were measured 19 days and 6–9 months after 131I treatment. The prevalence of iatrogenic hypothyroidism was assessed with the results obtained 6–9 months after 131I treatment.
Results
The prevalence of overt and subclinical hypothyroidism 6–9 months after 131I treatment was 40.0% (22/55 cats) and 12.7% (7/55 cats). Overt hypothyroidism with azotaemia was diagnosed in 8/55 (14.5%) cats. The positive and negative predictive values for the prediction of the development of iatrogenic hypothyroidism 6–9 months after 131I treatment were 72.2% and 80.0%, respectively, for a low serum T4 concentration, and 75.0% and 44.6%, respectively, for an increased serum TSH concentration.
Conclusions and relevance
The use of an individualised scoring system is effective in determining the 131I dose for the treatment of hyperthyroid cats. However, the prevalence of overt hypothyroidism was higher in comparison with other studies using different dosing protocols. Further studies comparing the efficacy of individualised scoring systems and different fixed doses to determine which method is superior are warranted.</description><identifier>ISSN: 1098-612X</identifier><identifier>ISSN: 1532-2750</identifier><identifier>EISSN: 1532-2750</identifier><identifier>DOI: 10.1177/1098612X18822396</identifier><identifier>PMID: 30667287</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Azotemia - etiology ; Azotemia - veterinary ; Cat Diseases - epidemiology ; Cat Diseases - etiology ; Cat Diseases - radiotherapy ; Cats ; England - epidemiology ; Female ; Hyperthyroidism - radiotherapy ; Hypothyroidism - epidemiology ; Hypothyroidism - etiology ; Hypothyroidism - veterinary ; Iatrogenic Disease - epidemiology ; Iatrogenic Disease - veterinary ; Iodine Radioisotopes - therapeutic use ; Male ; Original ; Prevalence ; Thyrotropin - blood ; Thyroxine - blood</subject><ispartof>Journal of feline medicine and surgery, 2019-12, Vol.21 (12), p.1149-1156</ispartof><rights>The Author(s) 2019</rights><rights>The Author(s) 2019 2019 International Society of Feline Medicine and American Association of Feline Practitioners</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-f74bc259f35f53449712c48f987ecdacd777d6d90b8ff578aff70076ad8fc0ce3</citedby><cites>FETCH-LOGICAL-c393t-f74bc259f35f53449712c48f987ecdacd777d6d90b8ff578aff70076ad8fc0ce3</cites><orcidid>0000-0002-9287-8931</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10814268/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10814268/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,21945,27830,27901,27902,44921,45309,53766,53768</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/1098612X18822396?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30667287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernandez, Yordan</creatorcontrib><creatorcontrib>Puig, Jordi</creatorcontrib><creatorcontrib>Powell, Roger</creatorcontrib><creatorcontrib>Seth, Mayank</creatorcontrib><title>Prevalence of iatrogenic hypothyroidism in hyperthyroid cats treated with radioiodine using an individualised scoring system</title><title>Journal of feline medicine and surgery</title><addtitle>J Feline Med Surg</addtitle><description>Objectives
The aim of this study was to report the prevalence of iatrogenic hypothyroidism, with or without azotaemia, based on the measurement of serum total thyroxine (T4), thyroid-stimulating hormone (TSH) and creatinine concentrations, in hyperthyroid cats undergoing radioiodine (131I) treatment where the 131I dose was calculated using a previously described scoring system. A secondary aim of the study was to determine the positive and negative predictive values of serum T4 and TSH concentrations obtained 19 days after treatment in order to predict the development of iatrogenic hypothyroidism 6–9 months after 131I treatment.
Methods
Serum T4, TSH and creatinine concentrations were measured 19 days and 6–9 months after 131I treatment. The prevalence of iatrogenic hypothyroidism was assessed with the results obtained 6–9 months after 131I treatment.
Results
The prevalence of overt and subclinical hypothyroidism 6–9 months after 131I treatment was 40.0% (22/55 cats) and 12.7% (7/55 cats). Overt hypothyroidism with azotaemia was diagnosed in 8/55 (14.5%) cats. The positive and negative predictive values for the prediction of the development of iatrogenic hypothyroidism 6–9 months after 131I treatment were 72.2% and 80.0%, respectively, for a low serum T4 concentration, and 75.0% and 44.6%, respectively, for an increased serum TSH concentration.
Conclusions and relevance
The use of an individualised scoring system is effective in determining the 131I dose for the treatment of hyperthyroid cats. However, the prevalence of overt hypothyroidism was higher in comparison with other studies using different dosing protocols. Further studies comparing the efficacy of individualised scoring systems and different fixed doses to determine which method is superior are warranted.</description><subject>Animals</subject><subject>Azotemia - etiology</subject><subject>Azotemia - veterinary</subject><subject>Cat Diseases - epidemiology</subject><subject>Cat Diseases - etiology</subject><subject>Cat Diseases - radiotherapy</subject><subject>Cats</subject><subject>England - epidemiology</subject><subject>Female</subject><subject>Hyperthyroidism - radiotherapy</subject><subject>Hypothyroidism - epidemiology</subject><subject>Hypothyroidism - etiology</subject><subject>Hypothyroidism - veterinary</subject><subject>Iatrogenic Disease - epidemiology</subject><subject>Iatrogenic Disease - veterinary</subject><subject>Iodine Radioisotopes - therapeutic use</subject><subject>Male</subject><subject>Original</subject><subject>Prevalence</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><issn>1098-612X</issn><issn>1532-2750</issn><issn>1532-2750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUuLFDEUhYMozji6dyVZuinNo6qSrESG8QEDulBwF9LJTXeGqqRNUi0N_nhTdDuo4Crhnu-chHsQek7JK0qFeE2JkiNl36iUjHE1PkCXdOCsY2IgD9u9yd2qX6AnpdwRQhRX7DG64GQcBZPiEv38nOFgJogWcPI4mJrTFmKweHfcp7o75hRcKDMOcZ1APo-wNbXgmsFUcPhHqDucjQspJBci4KWEuMUmNpsLh-AWM4XSwGJTXpVyLBXmp-iRN1OBZ-fzCn19d_Pl-kN3--n9x-u3t53litfOi35j2aA8H_zA-14JymwvvZICrDPWCSHc6BTZSO8HIY33ghAxGie9JRb4FXpzyt0vmxmchVizmfQ-h9nko04m6L-VGHZ6mw6aEkl7NsqW8PKckNP3BUrVcygWpslESEvRjIp1tYNUDSUn1OZUSgZ__w4lem1N_9tas7z483_3ht81NaA7AcVsQd-lJce2r_8H_gLIRqUl</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Fernandez, Yordan</creator><creator>Puig, Jordi</creator><creator>Powell, Roger</creator><creator>Seth, Mayank</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9287-8931</orcidid></search><sort><creationdate>20191201</creationdate><title>Prevalence of iatrogenic hypothyroidism in hyperthyroid cats treated with radioiodine using an individualised scoring system</title><author>Fernandez, Yordan ; Puig, Jordi ; Powell, Roger ; Seth, Mayank</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-f74bc259f35f53449712c48f987ecdacd777d6d90b8ff578aff70076ad8fc0ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Azotemia - etiology</topic><topic>Azotemia - veterinary</topic><topic>Cat Diseases - epidemiology</topic><topic>Cat Diseases - etiology</topic><topic>Cat Diseases - radiotherapy</topic><topic>Cats</topic><topic>England - epidemiology</topic><topic>Female</topic><topic>Hyperthyroidism - radiotherapy</topic><topic>Hypothyroidism - epidemiology</topic><topic>Hypothyroidism - etiology</topic><topic>Hypothyroidism - veterinary</topic><topic>Iatrogenic Disease - epidemiology</topic><topic>Iatrogenic Disease - veterinary</topic><topic>Iodine Radioisotopes - therapeutic use</topic><topic>Male</topic><topic>Original</topic><topic>Prevalence</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernandez, Yordan</creatorcontrib><creatorcontrib>Puig, Jordi</creatorcontrib><creatorcontrib>Powell, Roger</creatorcontrib><creatorcontrib>Seth, Mayank</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of feline medicine and surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Fernandez, Yordan</au><au>Puig, Jordi</au><au>Powell, Roger</au><au>Seth, Mayank</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of iatrogenic hypothyroidism in hyperthyroid cats treated with radioiodine using an individualised scoring system</atitle><jtitle>Journal of feline medicine and surgery</jtitle><addtitle>J Feline Med Surg</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>21</volume><issue>12</issue><spage>1149</spage><epage>1156</epage><pages>1149-1156</pages><issn>1098-612X</issn><issn>1532-2750</issn><eissn>1532-2750</eissn><abstract>Objectives
The aim of this study was to report the prevalence of iatrogenic hypothyroidism, with or without azotaemia, based on the measurement of serum total thyroxine (T4), thyroid-stimulating hormone (TSH) and creatinine concentrations, in hyperthyroid cats undergoing radioiodine (131I) treatment where the 131I dose was calculated using a previously described scoring system. A secondary aim of the study was to determine the positive and negative predictive values of serum T4 and TSH concentrations obtained 19 days after treatment in order to predict the development of iatrogenic hypothyroidism 6–9 months after 131I treatment.
Methods
Serum T4, TSH and creatinine concentrations were measured 19 days and 6–9 months after 131I treatment. The prevalence of iatrogenic hypothyroidism was assessed with the results obtained 6–9 months after 131I treatment.
Results
The prevalence of overt and subclinical hypothyroidism 6–9 months after 131I treatment was 40.0% (22/55 cats) and 12.7% (7/55 cats). Overt hypothyroidism with azotaemia was diagnosed in 8/55 (14.5%) cats. The positive and negative predictive values for the prediction of the development of iatrogenic hypothyroidism 6–9 months after 131I treatment were 72.2% and 80.0%, respectively, for a low serum T4 concentration, and 75.0% and 44.6%, respectively, for an increased serum TSH concentration.
Conclusions and relevance
The use of an individualised scoring system is effective in determining the 131I dose for the treatment of hyperthyroid cats. However, the prevalence of overt hypothyroidism was higher in comparison with other studies using different dosing protocols. Further studies comparing the efficacy of individualised scoring systems and different fixed doses to determine which method is superior are warranted.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>30667287</pmid><doi>10.1177/1098612X18822396</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-9287-8931</orcidid></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 1098-612X |
| ispartof | Journal of feline medicine and surgery, 2019-12, Vol.21 (12), p.1149-1156 |
| issn | 1098-612X 1532-2750 1532-2750 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10814268 |
| source | Sage Journals GOLD Open Access 2024 |
| subjects | Animals Azotemia - etiology Azotemia - veterinary Cat Diseases - epidemiology Cat Diseases - etiology Cat Diseases - radiotherapy Cats England - epidemiology Female Hyperthyroidism - radiotherapy Hypothyroidism - epidemiology Hypothyroidism - etiology Hypothyroidism - veterinary Iatrogenic Disease - epidemiology Iatrogenic Disease - veterinary Iodine Radioisotopes - therapeutic use Male Original Prevalence Thyrotropin - blood Thyroxine - blood |
| title | Prevalence of iatrogenic hypothyroidism in hyperthyroid cats treated with radioiodine using an individualised scoring system |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T04%3A53%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_AFRWT&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence%20of%20iatrogenic%20hypothyroidism%20in%20hyperthyroid%20cats%20treated%20with%20radioiodine%20using%20an%20individualised%20scoring%20system&rft.jtitle=Journal%20of%20feline%20medicine%20and%20surgery&rft.au=Fernandez,%20Yordan&rft.date=2019-12-01&rft.volume=21&rft.issue=12&rft.spage=1149&rft.epage=1156&rft.pages=1149-1156&rft.issn=1098-612X&rft.eissn=1532-2750&rft_id=info:doi/10.1177/1098612X18822396&rft_dat=%3Cproquest_AFRWT%3E2179392589%3C/proquest_AFRWT%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2179392589&rft_id=info:pmid/30667287&rft_sage_id=10.1177_1098612X18822396&rfr_iscdi=true |