Selectivity and Resolving Power of Hydrophobic Interaction Chromatography Targeting the Separation of Monoclonal Antibody Variants

This study presents a comprehensive investigation of the mechanistic understanding of retention and selectivity in hydrophobic interaction chromatography. It provides valuable insights into crucial method-development parameters involved in achieving chromatographic resolution for profiling molecular...

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Veröffentlicht in:	Analytical chemistry (Washington) 2024-01, Vol.96 (3), p.1121-1128
Hauptverfasser:	Ewonde Ewonde, Raphael, Böttinger, Katharina, De Vos, Jelle, Lingg, Nico, Jungbauer, Alois, Pohl, Christopher A., Huber, Christian G., Desmet, Gert, Eeltink, Sebastiaan
Format:	Artikel
Sprache:	eng
Schlagworte:	Chloride ions Chromatography Hydrophobicity Ions Liquid chromatography Mass spectrometry Mass spectroscopy Monoclonal antibodies Oxidation Peptide mapping Peptides Polymers Proteins Resolution Retention Spatial distribution Steric effects Surface area Trastuzumab
Online-Zugang:	Volltext
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