GDF15 linked to maternal risk of nausea and vomiting during pregnancy

GDF15, a hormone acting on the brainstem, has been implicated in the nausea and vomiting of pregnancy, including its most severe form, hyperemesis gravidarum (HG), but a full mechanistic understanding is lacking 1 – 4 . Here we report that fetal production of GDF15 and maternal sensitivity to it bot...

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Veröffentlicht in:	Nature (London) 2024-01, Vol.625 (7996), p.760-767
Hauptverfasser:	Fejzo, M., Rocha, N., Cimino, I., Lockhart, S. M., Petry, C. J., Kay, R. G., Burling, K., Barker, P., George, A. L., Yasara, N., Premawardhena, A., Gong, S., Cook, E., Rimmington, D., Rainbow, K., Withers, D. J., Cortessis, V., Mullin, P. M., MacGibbon, K. W., Jin, E., Kam, A., Campbell, A., Polasek, O., Tzoneva, G., Gribble, F. M., Yeo, G. S. H., Lam, B. Y. H., Saudek, V., Hughes, I. A., Ong, K. K., Perry, J. R. B., Sutton Cole, A., Baumgarten, M., Welsh, P., Sattar, N., Smith, G. C. S., Charnock-Jones, D. S., Coll, A. P., Meek, C. L., Mettananda, S., Hayward, C., Mancuso, N., O’Rahilly, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	45 631/208/205 64/60 692/308/575 692/699/2732 82/1 82/58 Animals beta-Thalassemia - blood beta-Thalassemia - metabolism Brain stem Desensitization Female Fetus - metabolism Fetuses Food intake Genetic diversity Genetic variance Growth Differentiation Factor 15 - blood Growth Differentiation Factor 15 - metabolism Hormones - blood Hormones - metabolism Humanities and Social Sciences Humans Hyperemesis Gravidarum - complications Hyperemesis Gravidarum - metabolism Hyperemesis Gravidarum - prevention & control Hyperemesis Gravidarum - therapy Mass spectrometry Mass spectroscopy Mice multidisciplinary Nausea Nausea - blood Nausea - complications Nausea - metabolism Peptides Placenta - metabolism Pregnancy Pregnancy complications Risk Science Science (multidisciplinary) Scientific imaging Sensitivity Thalassemia Vomiting Vomiting - blood Vomiting - complications Vomiting - metabolism
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