Structure of a tripartite protein complex that targets toxins to the type VII secretion system

Type VII secretion systems are membrane-embedded nanomachines used by Gram-positive bacteria to export effector proteins from the cytoplasm to the extracellular environment. Many of these effectors are polymorphic toxins comprised of an N-terminal Leu-x-Gly (LXG) domain of unknown function and a C-t...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2024-01, Vol.121 (3), p.e2312455121
Hauptverfasser: Klein, Timothy A, Shah, Prakhar Y, Gkragkopoulou, Polyniki, Grebenc, Dirk W, Kim, Youngchang, Whitney, John C
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Sprache:eng
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