Neuroblastoma differentiation in vivo excludes cranial tumors

Neuroblastoma (NB), the most common cancer in the first year of life, presents almost exclusively in the trunk. To understand why an early-onset cancer would have such a specific localization, we xenotransplanted human NB cells into discrete neural crest (NC) streams in zebrafish embryos. Here, we d...

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Veröffentlicht in:	Developmental cell 2021-10, Vol.56 (19), p.2752-2764.e6
Hauptverfasser:	Treffy, Randall W., Rajan, Sriivatsan G., Jiang, Xinghang, Nacke, Lynne M., Malkana, Usama A., Naiche, L.A., Bergey, Dani E., Santana, Dianicha, Rajagopalan, Vinodh, Kitajewski, Jan K., O’Bryan, John P., Saxena, Ankur
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain-Derived Neurotrophic Factor - metabolism Cell Differentiation - physiology Cell Line, Tumor Cell Movement - physiology differentiating microenvironment Female Humans live imaging Male Mice Neural Crest - metabolism neuroblastoma Neuroblastoma - metabolism neuronal differentiation Neurons - cytology Neurons - physiology pediatric cancer Signal Transduction Transplantation, Heterologous - methods Tretinoin - metabolism Tretinoin - pharmacology Tumor Microenvironment Zebrafish - metabolism
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