Research progress and application of single-cell sequencing in head and neck malignant tumors
Single-cell sequencing (SCS) is a technology that separates thousands of cells from the organism and accurately analyzes the genetic material expressed in each cell using high-throughput sequencing technology. Unlike the traditional bulk sequencing approach, which can only provide the average value...
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| Veröffentlicht in: | Cancer gene therapy 2024, Vol.31 (1), p.18-27 |
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| creator | Qu, Siyuan Gong, Mengdan Deng, Yongqin Xiang, Yizhen Ye, Dong |
| description | Single-cell sequencing (SCS) is a technology that separates thousands of cells from the organism and accurately analyzes the genetic material expressed in each cell using high-throughput sequencing technology. Unlike the traditional bulk sequencing approach, which can only provide the average value of a cell population and cannot obtain specific single-cell data, single-cell sequencing can identify the gene sequence and expression changes of a single cell, and reflects the differences between genetic material and protein between cells, and ultimately the role played by the tumor microenvironment. single-cell sequencing can further explore the pathogenesis of head and neck malignancies from the single-cell biological level and provides a theoretical basis for the clinical diagnosis and treatment of head and neck malignancies. This article will systematically introduce the latest progress and application of single-cell sequencing in malignant head and neck tumors. |
| doi_str_mv | 10.1038/s41417-023-00691-2 |
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| ispartof | Cancer gene therapy, 2024, Vol.31 (1), p.18-27 |
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| subjects | 38/39 38/43 38/61 38/77 631/67/2329 631/67/69 Biomedical and Life Sciences Biomedicine Gene Expression Gene Therapy Head & neck cancer Head and neck Head and Neck Neoplasms - diagnosis Head and Neck Neoplasms - genetics High-Throughput Nucleotide Sequencing Humans Malignancy Next-generation sequencing Review Review Article Tumor microenvironment Tumor Microenvironment - genetics Tumors |
| title | Research progress and application of single-cell sequencing in head and neck malignant tumors |
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