Thalamic connectivity topography in newborns with spina bifida: association with neurological functional level but not developmental outcome at 2 years
Abstract Spina bifida affects spinal cord and cerebral development, leading to motor and cognitive delay. We investigated whether there are associations between thalamocortical connectivity topography, neurological function, and developmental outcomes in open spina bifida. Diffusion tensor MRI was u...
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| Veröffentlicht in: | Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2024-01, Vol.34 (1) |
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| container_title | Cerebral cortex (New York, N.Y. 1991) |
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| creator | Ji, Hui Payette, Kelly Speckert, Anna Tuura, Ruth Grehten, Patrice Kottke, Raimund Ochseinbein-Kölble, Nicole Hagmann, Cornelia Mazzone, Luca Meuli, Martin Padden, Beth Hackenberg, Annette Wille, David-Alexander Moehrlen, Ueli Latal, Beatrice SPINA BIFIDA STUDY GROUP ZURICH Jakab, Andras |
| description | Abstract
Spina bifida affects spinal cord and cerebral development, leading to motor and cognitive delay. We investigated whether there are associations between thalamocortical connectivity topography, neurological function, and developmental outcomes in open spina bifida. Diffusion tensor MRI was used to assess thalamocortical connectivity in 44 newborns with open spina bifida who underwent prenatal surgical repair. We quantified the volume of clusters formed based on the strongest probabilistic connectivity to the frontal, parietal, and temporal cortex. Developmental outcomes were assessed using the Bayley III Scales, while the functional level of the lesion was assessed by neurological examination at 2 years of age. Higher functional level was associated with smaller thalamo-parietal, while lower functional level was associated with smaller thalamo-temporal connectivity clusters (Bonferroni-corrected P |
| doi_str_mv | 10.1093/cercor/bhad438 |
| format | Article |
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Spina bifida affects spinal cord and cerebral development, leading to motor and cognitive delay. We investigated whether there are associations between thalamocortical connectivity topography, neurological function, and developmental outcomes in open spina bifida. Diffusion tensor MRI was used to assess thalamocortical connectivity in 44 newborns with open spina bifida who underwent prenatal surgical repair. We quantified the volume of clusters formed based on the strongest probabilistic connectivity to the frontal, parietal, and temporal cortex. Developmental outcomes were assessed using the Bayley III Scales, while the functional level of the lesion was assessed by neurological examination at 2 years of age. Higher functional level was associated with smaller thalamo-parietal, while lower functional level was associated with smaller thalamo-temporal connectivity clusters (Bonferroni-corrected P < 0.05). Lower functional levels were associated with weaker thalamic temporal connectivity, particularly in the ventrolateral and ventral anterior nuclei. No associations were found between thalamocortical connectivity and developmental outcomes. Our findings suggest that altered thalamocortical circuitry development in open spina bifida may contribute to impaired lower extremity function, impacting motor function and independent ambulation. We hypothesize that the neurologic function might not merely be caused by the spinal cord lesion, but further impacted by the disruption of cerebral neuronal circuitry.</description><identifier>ISSN: 1047-3211</identifier><identifier>EISSN: 1460-2199</identifier><identifier>DOI: 10.1093/cercor/bhad438</identifier><identifier>PMID: 37991274</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Diffusion Tensor Imaging ; Female ; Humans ; Infant, Newborn ; Original ; Pregnancy ; Spina Bifida Cystica - complications ; Spinal Cord - pathology ; Spinal Dysraphism - complications ; Spinal Dysraphism - diagnostic imaging ; Spinal Dysraphism - psychology ; Thalamus - pathology</subject><ispartof>Cerebral cortex (New York, N.Y. 1991), 2024-01, Vol.34 (1)</ispartof><rights>The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com. 2023</rights><rights>The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c380t-7823a99534237d25802abc519fcf21e2e55426c3e67d04de0e9b01c5376eaadd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1584,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37991274$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ji, Hui</creatorcontrib><creatorcontrib>Payette, Kelly</creatorcontrib><creatorcontrib>Speckert, Anna</creatorcontrib><creatorcontrib>Tuura, Ruth</creatorcontrib><creatorcontrib>Grehten, Patrice</creatorcontrib><creatorcontrib>Kottke, Raimund</creatorcontrib><creatorcontrib>Ochseinbein-Kölble, Nicole</creatorcontrib><creatorcontrib>Hagmann, Cornelia</creatorcontrib><creatorcontrib>Mazzone, Luca</creatorcontrib><creatorcontrib>Meuli, Martin</creatorcontrib><creatorcontrib>Padden, Beth</creatorcontrib><creatorcontrib>Hackenberg, Annette</creatorcontrib><creatorcontrib>Wille, David-Alexander</creatorcontrib><creatorcontrib>Moehrlen, Ueli</creatorcontrib><creatorcontrib>Latal, Beatrice</creatorcontrib><creatorcontrib>SPINA BIFIDA STUDY GROUP ZURICH</creatorcontrib><creatorcontrib>Jakab, Andras</creatorcontrib><title>Thalamic connectivity topography in newborns with spina bifida: association with neurological functional level but not developmental outcome at 2 years</title><title>Cerebral cortex (New York, N.Y. 1991)</title><addtitle>Cereb Cortex</addtitle><description>Abstract
Spina bifida affects spinal cord and cerebral development, leading to motor and cognitive delay. We investigated whether there are associations between thalamocortical connectivity topography, neurological function, and developmental outcomes in open spina bifida. Diffusion tensor MRI was used to assess thalamocortical connectivity in 44 newborns with open spina bifida who underwent prenatal surgical repair. We quantified the volume of clusters formed based on the strongest probabilistic connectivity to the frontal, parietal, and temporal cortex. Developmental outcomes were assessed using the Bayley III Scales, while the functional level of the lesion was assessed by neurological examination at 2 years of age. Higher functional level was associated with smaller thalamo-parietal, while lower functional level was associated with smaller thalamo-temporal connectivity clusters (Bonferroni-corrected P < 0.05). Lower functional levels were associated with weaker thalamic temporal connectivity, particularly in the ventrolateral and ventral anterior nuclei. No associations were found between thalamocortical connectivity and developmental outcomes. Our findings suggest that altered thalamocortical circuitry development in open spina bifida may contribute to impaired lower extremity function, impacting motor function and independent ambulation. We hypothesize that the neurologic function might not merely be caused by the spinal cord lesion, but further impacted by the disruption of cerebral neuronal circuitry.</description><subject>Diffusion Tensor Imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Original</subject><subject>Pregnancy</subject><subject>Spina Bifida Cystica - complications</subject><subject>Spinal Cord - pathology</subject><subject>Spinal Dysraphism - complications</subject><subject>Spinal Dysraphism - diagnostic imaging</subject><subject>Spinal Dysraphism - psychology</subject><subject>Thalamus - pathology</subject><issn>1047-3211</issn><issn>1460-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><recordid>eNqFkctu1TAQhiMEoqWwZYm8hEVaX3IzG1RV3KRKbMramjiTE6PEE2znVOdNWPIsPBk5yqGCFSuP9X_-PdKXZS8FvxRcqyuLwVK4agfoCtU8ys5FUfFcCq0frzMv6lxJIc6yZzF-41zUspRPszNVay1kXZxnP-4GGGFyllnyHm1ye5cOLNFMuwDzcGDOM4_3LQUf2b1LA4uz88Ba17sO3jKIkayD5Mhvsccl0Eg7Z2Fk_eLtMVrHEfc4snZJzFNi3fFG84Q-rRktydKEDBKTv34eEEJ8nj3pYYz44nReZF8_vL-7-ZTffvn4-eb6Nreq4SmvG6lA61IVUtWdLBsuobWl0L3tpUCJZVnIyiqs6o4XHXLULRe2VHWFAF2nLrJ3W--8tBN2dl0owGjm4CYIB0PgzL-Jd4PZ0d4IXmtVVtXa8PrUEOj7gjGZyUWL4wgeaYlGNlpWFV81rOjlhtpAMQbsH_4R3Bx9ms2nOflcH7z6e7sH_I_AFXizAbTM_yv7DRMqssA</recordid><startdate>20240114</startdate><enddate>20240114</enddate><creator>Ji, Hui</creator><creator>Payette, Kelly</creator><creator>Speckert, Anna</creator><creator>Tuura, Ruth</creator><creator>Grehten, Patrice</creator><creator>Kottke, Raimund</creator><creator>Ochseinbein-Kölble, Nicole</creator><creator>Hagmann, Cornelia</creator><creator>Mazzone, Luca</creator><creator>Meuli, Martin</creator><creator>Padden, Beth</creator><creator>Hackenberg, Annette</creator><creator>Wille, David-Alexander</creator><creator>Moehrlen, Ueli</creator><creator>Latal, Beatrice</creator><creator>SPINA BIFIDA STUDY GROUP ZURICH</creator><creator>Jakab, Andras</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240114</creationdate><title>Thalamic connectivity topography in newborns with spina bifida: association with neurological functional level but not developmental outcome at 2 years</title><author>Ji, Hui ; Payette, Kelly ; Speckert, Anna ; Tuura, Ruth ; Grehten, Patrice ; Kottke, Raimund ; Ochseinbein-Kölble, Nicole ; Hagmann, Cornelia ; Mazzone, Luca ; Meuli, Martin ; Padden, Beth ; Hackenberg, Annette ; Wille, David-Alexander ; Moehrlen, Ueli ; Latal, Beatrice ; SPINA BIFIDA STUDY GROUP ZURICH ; Jakab, Andras</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-7823a99534237d25802abc519fcf21e2e55426c3e67d04de0e9b01c5376eaadd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Diffusion Tensor Imaging</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Original</topic><topic>Pregnancy</topic><topic>Spina Bifida Cystica - complications</topic><topic>Spinal Cord - pathology</topic><topic>Spinal Dysraphism - complications</topic><topic>Spinal Dysraphism - diagnostic imaging</topic><topic>Spinal Dysraphism - psychology</topic><topic>Thalamus - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ji, Hui</creatorcontrib><creatorcontrib>Payette, Kelly</creatorcontrib><creatorcontrib>Speckert, Anna</creatorcontrib><creatorcontrib>Tuura, Ruth</creatorcontrib><creatorcontrib>Grehten, Patrice</creatorcontrib><creatorcontrib>Kottke, Raimund</creatorcontrib><creatorcontrib>Ochseinbein-Kölble, Nicole</creatorcontrib><creatorcontrib>Hagmann, Cornelia</creatorcontrib><creatorcontrib>Mazzone, Luca</creatorcontrib><creatorcontrib>Meuli, Martin</creatorcontrib><creatorcontrib>Padden, Beth</creatorcontrib><creatorcontrib>Hackenberg, Annette</creatorcontrib><creatorcontrib>Wille, David-Alexander</creatorcontrib><creatorcontrib>Moehrlen, Ueli</creatorcontrib><creatorcontrib>Latal, Beatrice</creatorcontrib><creatorcontrib>SPINA BIFIDA STUDY GROUP ZURICH</creatorcontrib><creatorcontrib>Jakab, Andras</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cerebral cortex (New York, N.Y. 1991)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ji, Hui</au><au>Payette, Kelly</au><au>Speckert, Anna</au><au>Tuura, Ruth</au><au>Grehten, Patrice</au><au>Kottke, Raimund</au><au>Ochseinbein-Kölble, Nicole</au><au>Hagmann, Cornelia</au><au>Mazzone, Luca</au><au>Meuli, Martin</au><au>Padden, Beth</au><au>Hackenberg, Annette</au><au>Wille, David-Alexander</au><au>Moehrlen, Ueli</au><au>Latal, Beatrice</au><au>SPINA BIFIDA STUDY GROUP ZURICH</au><au>Jakab, Andras</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thalamic connectivity topography in newborns with spina bifida: association with neurological functional level but not developmental outcome at 2 years</atitle><jtitle>Cerebral cortex (New York, N.Y. 1991)</jtitle><addtitle>Cereb Cortex</addtitle><date>2024-01-14</date><risdate>2024</risdate><volume>34</volume><issue>1</issue><issn>1047-3211</issn><eissn>1460-2199</eissn><abstract>Abstract
Spina bifida affects spinal cord and cerebral development, leading to motor and cognitive delay. We investigated whether there are associations between thalamocortical connectivity topography, neurological function, and developmental outcomes in open spina bifida. Diffusion tensor MRI was used to assess thalamocortical connectivity in 44 newborns with open spina bifida who underwent prenatal surgical repair. We quantified the volume of clusters formed based on the strongest probabilistic connectivity to the frontal, parietal, and temporal cortex. Developmental outcomes were assessed using the Bayley III Scales, while the functional level of the lesion was assessed by neurological examination at 2 years of age. Higher functional level was associated with smaller thalamo-parietal, while lower functional level was associated with smaller thalamo-temporal connectivity clusters (Bonferroni-corrected P < 0.05). Lower functional levels were associated with weaker thalamic temporal connectivity, particularly in the ventrolateral and ventral anterior nuclei. No associations were found between thalamocortical connectivity and developmental outcomes. Our findings suggest that altered thalamocortical circuitry development in open spina bifida may contribute to impaired lower extremity function, impacting motor function and independent ambulation. We hypothesize that the neurologic function might not merely be caused by the spinal cord lesion, but further impacted by the disruption of cerebral neuronal circuitry.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>37991274</pmid><doi>10.1093/cercor/bhad438</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1047-3211 |
| ispartof | Cerebral cortex (New York, N.Y. 1991), 2024-01, Vol.34 (1) |
| issn | 1047-3211 1460-2199 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Diffusion Tensor Imaging Female Humans Infant, Newborn Original Pregnancy Spina Bifida Cystica - complications Spinal Cord - pathology Spinal Dysraphism - complications Spinal Dysraphism - diagnostic imaging Spinal Dysraphism - psychology Thalamus - pathology |
| title | Thalamic connectivity topography in newborns with spina bifida: association with neurological functional level but not developmental outcome at 2 years |
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