Clinical Utility of Soluble Lectin Type Oxidized Low-Density Lipoprotein Receptor as a Biomarker for Myocardial Infarction and Stable Angina
Background and objectives Endothelial soluble lectin-type oxidized low-density lipoprotein receptor 1 (sLOX-1) recognizes oxidized low-density lipoprotein (LDL) and triggers downstream signaling leading to atherosclerosis. The objective of this study was to demonstrate the utility of sLOX-1 as a bio...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2023-12, Vol.15 (12), p.e50719-e50719 |
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| creator | Narsini, Radhakishan Bhaskar, Vijaya Luqman, Hajra O, Sai Satish Parupati, Shyam Sundar R B V, Ranga Reddy A Krishna Mohan, Iyyapu |
| description | Background and objectives Endothelial soluble lectin-type oxidized low-density lipoprotein receptor 1 (sLOX-1) recognizes oxidized low-density lipoprotein (LDL) and triggers downstream signaling leading to atherosclerosis. The objective of this study was to demonstrate the utility of sLOX-1 as a biomarker for detecting acute myocardial infarction (MI) and stable angina (SA) and to develop a diagnostic algorithm for distinguishing coronary vasospasm from coronary plaque rupture. Methods We enrolled 62 patients who underwent diagnostic coronary angiography (CAG) and 30 healthy controls (21 men and nine women) and measured sLOX-1, troponin I, and cardiac myosin-binding protein C (c-MyBPC) using commercial kits. Results Patients with MI exhibited higher sLOX-1 levels (301.55 ± 196.16 pg/ml) than patients with stable angina (220.76 ± 103.65 pg/ml) and healthy controls (121.14 ± 77.10, F: 10.55, p |
| doi_str_mv | 10.7759/cureus.50719 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10792998</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2920588115</sourcerecordid><originalsourceid>FETCH-LOGICAL-c300t-94f1973ab0ecdc7e52ea1b73c24b916184a04e5fe6a09fbb1e0095a2c88ca4633</originalsourceid><addsrcrecordid>eNpdkUFPFTEUhRujEYLsXJsmblw42HZmXtuVwYcKyRgSgXVzp3MHi_PaoZ0Bnr_BH20fDwm6atP75dxzegh5zdmBlLX-YOeIczqomeT6GdkVfKEKxVX1_Ml9h-yndMUY40wKJtlLslMqUVa6krvk93Jw3lkY6MXkBjetaejpWRjmdkDaoJ2cp-frEenpnevcL-xoE26LI_RpwzZuDGMME2bqO1ocpxApJAr0kwsriD8x0j4_fVsHC7Fzec2J7yFm2eAp-I6eTbDZdOgvnYdX5EUPQ8L9h3OPXHz5fL48LprTryfLw6awJWNToauea1lCy9B2VmItEHgrSyuqVvNFjgyswrrHBTDdty1HxnQNwiploVqU5R75uNUd53aFnUU_RRjMGF32vDYBnPl34t0PcxluTP5BLbRWWeHdg0IM1zOmyaxcsjgM4DHMyYjso8ow36Bv_0Ovwhx9zpcpwWqlOK8z9X5L2RhSitg_uuHMbKo226rNfdUZf_M0wSP8t9jyD6zzqCo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2920588115</pqid></control><display><type>article</type><title>Clinical Utility of Soluble Lectin Type Oxidized Low-Density Lipoprotein Receptor as a Biomarker for Myocardial Infarction and Stable Angina</title><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Narsini, Radhakishan ; Bhaskar, Vijaya ; Luqman, Hajra ; O, Sai Satish ; Parupati, Shyam Sundar R ; B V, Ranga Reddy A ; Krishna Mohan, Iyyapu</creator><creatorcontrib>Narsini, Radhakishan ; Bhaskar, Vijaya ; Luqman, Hajra ; O, Sai Satish ; Parupati, Shyam Sundar R ; B V, Ranga Reddy A ; Krishna Mohan, Iyyapu</creatorcontrib><description>Background and objectives Endothelial soluble lectin-type oxidized low-density lipoprotein receptor 1 (sLOX-1) recognizes oxidized low-density lipoprotein (LDL) and triggers downstream signaling leading to atherosclerosis. The objective of this study was to demonstrate the utility of sLOX-1 as a biomarker for detecting acute myocardial infarction (MI) and stable angina (SA) and to develop a diagnostic algorithm for distinguishing coronary vasospasm from coronary plaque rupture. Methods We enrolled 62 patients who underwent diagnostic coronary angiography (CAG) and 30 healthy controls (21 men and nine women) and measured sLOX-1, troponin I, and cardiac myosin-binding protein C (c-MyBPC) using commercial kits. Results Patients with MI exhibited higher sLOX-1 levels (301.55 ± 196.16 pg/ml) than patients with stable angina (220.76 ± 103.65 pg/ml) and healthy controls (121.14 ± 77.10, F: 10.55, p<0.001). Although higher troponin I levels were detected in MI patients (263.00 ± 493.00 vs. 3.19 ± 2.15 ng/ml, p=0.0019), no significant elevation was observed in SA patients (1.91 ± 0.79 ng/ml). Plasma sLOX-1 levels showed a positive association with age (r=0.37, p=0.003), but not with gender (r=0.04, p=0.75). Troponin I showed no association with age (r=0.12, p=0.36) or gender (r=0.06, p=0.62). Receiver operating characteristic (ROC) curves revealed that among the three biomarkers, troponin-I showed a higher area under the curve (AUC) (AUC: 0.941), followed by sLOX-1 (AUC: 0.888), while c-MyBPC showed no clinical utility in the detection of MI (AUC: 0.666). Conclusions A marked elevation of sLOX-1 can detect MI and differentiate the presence or absence of plaque rupture, along with diagnosing stable angina.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.50719</identifier><identifier>PMID: 38234947</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Angina pectoris ; Apoptosis ; Atherosclerosis ; Biomarkers ; Cardiac/Thoracic/Vascular Surgery ; Cardiology ; Cardiovascular disease ; Coronary vessels ; Gender ; Heart attacks ; Kinases ; Lectins ; Lipoproteins ; Low density lipoprotein receptors ; Medical imaging ; Mortality ; Preventive Medicine ; Proteins ; Variance analysis ; Vein & artery diseases</subject><ispartof>Curēus (Palo Alto, CA), 2023-12, Vol.15 (12), p.e50719-e50719</ispartof><rights>Copyright © 2023, Narsini et al.</rights><rights>Copyright © 2023, Narsini et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2023, Narsini et al. 2023 Narsini et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c300t-94f1973ab0ecdc7e52ea1b73c24b916184a04e5fe6a09fbb1e0095a2c88ca4633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10792998/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10792998/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38234947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Narsini, Radhakishan</creatorcontrib><creatorcontrib>Bhaskar, Vijaya</creatorcontrib><creatorcontrib>Luqman, Hajra</creatorcontrib><creatorcontrib>O, Sai Satish</creatorcontrib><creatorcontrib>Parupati, Shyam Sundar R</creatorcontrib><creatorcontrib>B V, Ranga Reddy A</creatorcontrib><creatorcontrib>Krishna Mohan, Iyyapu</creatorcontrib><title>Clinical Utility of Soluble Lectin Type Oxidized Low-Density Lipoprotein Receptor as a Biomarker for Myocardial Infarction and Stable Angina</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Background and objectives Endothelial soluble lectin-type oxidized low-density lipoprotein receptor 1 (sLOX-1) recognizes oxidized low-density lipoprotein (LDL) and triggers downstream signaling leading to atherosclerosis. The objective of this study was to demonstrate the utility of sLOX-1 as a biomarker for detecting acute myocardial infarction (MI) and stable angina (SA) and to develop a diagnostic algorithm for distinguishing coronary vasospasm from coronary plaque rupture. Methods We enrolled 62 patients who underwent diagnostic coronary angiography (CAG) and 30 healthy controls (21 men and nine women) and measured sLOX-1, troponin I, and cardiac myosin-binding protein C (c-MyBPC) using commercial kits. Results Patients with MI exhibited higher sLOX-1 levels (301.55 ± 196.16 pg/ml) than patients with stable angina (220.76 ± 103.65 pg/ml) and healthy controls (121.14 ± 77.10, F: 10.55, p<0.001). Although higher troponin I levels were detected in MI patients (263.00 ± 493.00 vs. 3.19 ± 2.15 ng/ml, p=0.0019), no significant elevation was observed in SA patients (1.91 ± 0.79 ng/ml). Plasma sLOX-1 levels showed a positive association with age (r=0.37, p=0.003), but not with gender (r=0.04, p=0.75). Troponin I showed no association with age (r=0.12, p=0.36) or gender (r=0.06, p=0.62). Receiver operating characteristic (ROC) curves revealed that among the three biomarkers, troponin-I showed a higher area under the curve (AUC) (AUC: 0.941), followed by sLOX-1 (AUC: 0.888), while c-MyBPC showed no clinical utility in the detection of MI (AUC: 0.666). Conclusions A marked elevation of sLOX-1 can detect MI and differentiate the presence or absence of plaque rupture, along with diagnosing stable angina.</description><subject>Angina pectoris</subject><subject>Apoptosis</subject><subject>Atherosclerosis</subject><subject>Biomarkers</subject><subject>Cardiac/Thoracic/Vascular Surgery</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Coronary vessels</subject><subject>Gender</subject><subject>Heart attacks</subject><subject>Kinases</subject><subject>Lectins</subject><subject>Lipoproteins</subject><subject>Low density lipoprotein receptors</subject><subject>Medical imaging</subject><subject>Mortality</subject><subject>Preventive Medicine</subject><subject>Proteins</subject><subject>Variance analysis</subject><subject>Vein & artery diseases</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkUFPFTEUhRujEYLsXJsmblw42HZmXtuVwYcKyRgSgXVzp3MHi_PaoZ0Bnr_BH20fDwm6atP75dxzegh5zdmBlLX-YOeIczqomeT6GdkVfKEKxVX1_Ml9h-yndMUY40wKJtlLslMqUVa6krvk93Jw3lkY6MXkBjetaejpWRjmdkDaoJ2cp-frEenpnevcL-xoE26LI_RpwzZuDGMME2bqO1ocpxApJAr0kwsriD8x0j4_fVsHC7Fzec2J7yFm2eAp-I6eTbDZdOgvnYdX5EUPQ8L9h3OPXHz5fL48LprTryfLw6awJWNToauea1lCy9B2VmItEHgrSyuqVvNFjgyswrrHBTDdty1HxnQNwiploVqU5R75uNUd53aFnUU_RRjMGF32vDYBnPl34t0PcxluTP5BLbRWWeHdg0IM1zOmyaxcsjgM4DHMyYjso8ow36Bv_0Ovwhx9zpcpwWqlOK8z9X5L2RhSitg_uuHMbKo226rNfdUZf_M0wSP8t9jyD6zzqCo</recordid><startdate>20231218</startdate><enddate>20231218</enddate><creator>Narsini, Radhakishan</creator><creator>Bhaskar, Vijaya</creator><creator>Luqman, Hajra</creator><creator>O, Sai Satish</creator><creator>Parupati, Shyam Sundar R</creator><creator>B V, Ranga Reddy A</creator><creator>Krishna Mohan, Iyyapu</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20231218</creationdate><title>Clinical Utility of Soluble Lectin Type Oxidized Low-Density Lipoprotein Receptor as a Biomarker for Myocardial Infarction and Stable Angina</title><author>Narsini, Radhakishan ; Bhaskar, Vijaya ; Luqman, Hajra ; O, Sai Satish ; Parupati, Shyam Sundar R ; B V, Ranga Reddy A ; Krishna Mohan, Iyyapu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-94f1973ab0ecdc7e52ea1b73c24b916184a04e5fe6a09fbb1e0095a2c88ca4633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Angina pectoris</topic><topic>Apoptosis</topic><topic>Atherosclerosis</topic><topic>Biomarkers</topic><topic>Cardiac/Thoracic/Vascular Surgery</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Coronary vessels</topic><topic>Gender</topic><topic>Heart attacks</topic><topic>Kinases</topic><topic>Lectins</topic><topic>Lipoproteins</topic><topic>Low density lipoprotein receptors</topic><topic>Medical imaging</topic><topic>Mortality</topic><topic>Preventive Medicine</topic><topic>Proteins</topic><topic>Variance analysis</topic><topic>Vein & artery diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Narsini, Radhakishan</creatorcontrib><creatorcontrib>Bhaskar, Vijaya</creatorcontrib><creatorcontrib>Luqman, Hajra</creatorcontrib><creatorcontrib>O, Sai Satish</creatorcontrib><creatorcontrib>Parupati, Shyam Sundar R</creatorcontrib><creatorcontrib>B V, Ranga Reddy A</creatorcontrib><creatorcontrib>Krishna Mohan, Iyyapu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Narsini, Radhakishan</au><au>Bhaskar, Vijaya</au><au>Luqman, Hajra</au><au>O, Sai Satish</au><au>Parupati, Shyam Sundar R</au><au>B V, Ranga Reddy A</au><au>Krishna Mohan, Iyyapu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Utility of Soluble Lectin Type Oxidized Low-Density Lipoprotein Receptor as a Biomarker for Myocardial Infarction and Stable Angina</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2023-12-18</date><risdate>2023</risdate><volume>15</volume><issue>12</issue><spage>e50719</spage><epage>e50719</epage><pages>e50719-e50719</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Background and objectives Endothelial soluble lectin-type oxidized low-density lipoprotein receptor 1 (sLOX-1) recognizes oxidized low-density lipoprotein (LDL) and triggers downstream signaling leading to atherosclerosis. The objective of this study was to demonstrate the utility of sLOX-1 as a biomarker for detecting acute myocardial infarction (MI) and stable angina (SA) and to develop a diagnostic algorithm for distinguishing coronary vasospasm from coronary plaque rupture. Methods We enrolled 62 patients who underwent diagnostic coronary angiography (CAG) and 30 healthy controls (21 men and nine women) and measured sLOX-1, troponin I, and cardiac myosin-binding protein C (c-MyBPC) using commercial kits. Results Patients with MI exhibited higher sLOX-1 levels (301.55 ± 196.16 pg/ml) than patients with stable angina (220.76 ± 103.65 pg/ml) and healthy controls (121.14 ± 77.10, F: 10.55, p<0.001). Although higher troponin I levels were detected in MI patients (263.00 ± 493.00 vs. 3.19 ± 2.15 ng/ml, p=0.0019), no significant elevation was observed in SA patients (1.91 ± 0.79 ng/ml). Plasma sLOX-1 levels showed a positive association with age (r=0.37, p=0.003), but not with gender (r=0.04, p=0.75). Troponin I showed no association with age (r=0.12, p=0.36) or gender (r=0.06, p=0.62). Receiver operating characteristic (ROC) curves revealed that among the three biomarkers, troponin-I showed a higher area under the curve (AUC) (AUC: 0.941), followed by sLOX-1 (AUC: 0.888), while c-MyBPC showed no clinical utility in the detection of MI (AUC: 0.666). Conclusions A marked elevation of sLOX-1 can detect MI and differentiate the presence or absence of plaque rupture, along with diagnosing stable angina.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>38234947</pmid><doi>10.7759/cureus.50719</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Angina pectoris Apoptosis Atherosclerosis Biomarkers Cardiac/Thoracic/Vascular Surgery Cardiology Cardiovascular disease Coronary vessels Gender Heart attacks Kinases Lectins Lipoproteins Low density lipoprotein receptors Medical imaging Mortality Preventive Medicine Proteins Variance analysis Vein & artery diseases |
| title | Clinical Utility of Soluble Lectin Type Oxidized Low-Density Lipoprotein Receptor as a Biomarker for Myocardial Infarction and Stable Angina |
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