Modulating Nrf-2/HO-1, apoptosis and oxidative stress signaling pathways by gabapentin ameliorates sepsis-induced acute kidney injury

Purpose Globally, sepsis, which is a major health issue resulting from severe infection-induced inflammation, is the fifth biggest cause of death. This research aimed to evaluate, for the first time, the molecular effects of gabapentin's possible nephroprotective potential on septic rats by cec...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2024-02, Vol.397 (2), p.947-958
Hauptverfasser:	Abdelnaser, Mahmoud, Alaaeldin, Rania, Attya, Mina Ezzat, Fathy, Moustafa
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - drug therapy Acute Kidney Injury - etiology Animals Apoptosis BAX protein Bcl-2 protein bcl-2-Associated X Protein - metabolism Biomedical and Life Sciences Biomedicine Blood levels Cecum Creatinine GA-binding protein Gabapentin Gabapentin - pharmacology Gene expression Genes IL-1β Inflammation Interleukin 6 Interleukin-6 - metabolism Kidneys Male Neurosciences NF-kappa B - metabolism NF-κB protein Oxidative Stress Pharmacology/Toxicology Proteins Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Rats, Wistar Renal function Sepsis Sepsis - complications Sepsis - drug therapy Signal Transduction Superoxide Dismutase - metabolism Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Western blotting
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!