Deoxyadenosine Bisphosphate Derivatives as Potent Antagonists at P2Y1 Receptors

Adenosine 3‘,5‘- and 2‘,5‘-bisphosphates previously were demonstrated to act as competitive antagonists at the P2Y1 receptor (Boyer et al. Mol. Pharmacol. 1996, 50, 1323−1329). 2‘- and 3‘-Deoxyadenosine bisphosphate analogues containing various structural modifications at the 2- and 6-positions of t...

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Veröffentlicht in:	Journal of medicinal chemistry 1998-01, Vol.41 (2), p.183-190
Hauptverfasser:	Camaioni, Emidio, Boyer, José L, Mohanram, Arvind, Harden, T. Kendall, Jacobson, Kenneth A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chromatography, High Pressure Liquid Deoxyadenine Nucleotides - chemistry Deoxyadenine Nucleotides - pharmacology Erythrocyte Membrane - drug effects Erythrocyte Membrane - metabolism Medical sciences Miscellaneous Models, Chemical Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Purinergic P2 Receptor Antagonists Receptors, Purinergic P2Y1 Structure-Activity Relationship Turkeys Type C Phospholipases - metabolism
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