Amine Basicity of Quinoline ATP Synthase Inhibitors Drives Antibacterial Activity against Pseudomonas aeruginosa

Pseudomonas aeruginosa (PA), a Gram-negative pathogen, is a common cause of nosocomial infections, especially in immunocompromised and cystic fibrosis patients. PA is intrinsically resistant to many currently prescribed antibiotics due to its tightly packed, anionic lipopolysaccharide outer membrane...

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Veröffentlicht in:	ACS medicinal chemistry letters 2024-01, Vol.15 (1), p.149-155
Hauptverfasser:	Ward, Katie T., Williams, Alexander P. L., Blair, Courtney A., Chatterjee, Ananya M., Karthikeyan, Abirami, Roper, Addison S., Kellogg, Casey N., Steed, P. Ryan, Wolfe, Amanda L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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