Effects of a Remote Multimodal Intervention Involving Diet, Walking Program, and Breathing Exercise on Quality of Life Among Newly Diagnosed People with Multiple Sclerosis: A Quasi-Experimental Non-Inferiority Pilot Study
Interventions involving diet, physical activity, and breathing exercises are shown to be beneficial in managing both fatigue and quality of life (QoL) related to MS; however, the impact of such interventions among people newly diagnosed with clinically isolated syndrome (CIS) or relapsing-remitting...
Gespeichert in:
Veröffentlicht in: | Degenerative neurological and neuromuscular disease 2024-01, Vol.14, p.1-14 |
---|---|
Hauptverfasser: | , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 14 |
---|---|
container_issue | |
container_start_page | 1 |
container_title | Degenerative neurological and neuromuscular disease |
container_volume | 14 |
creator | Saxby, Solange M Shemirani, Farnoosh Crippes, Landon J Ehlinger, Mary A Brooks, Lisa Bisht, Babita Titcomb, Tyler J Rubenstein, Linda M Eyck, Patrick Ten Hoth, Karin F Gill, Christine Kamholz, John Snetselaar, Linda G Wahls, Terry L |
description | Interventions involving diet, physical activity, and breathing exercises are shown to be beneficial in managing both fatigue and quality of life (QoL) related to MS; however, the impact of such interventions among people newly diagnosed with clinically isolated syndrome (CIS) or relapsing-remitting multiple sclerosis (RRMS) who decline disease-modifying therapies (DMTs) is unknown.
A 12-month prospective quasi-experimental non-inferiority trial recruited people newly diagnosed with CIS or RRMS who voluntarily declined DMTs (health behavior group; HB, n = 29) or followed standard of care (SOC, n = 15). Participants in the HB group were remotely coached on the study diet, moderate-intensity walking, and breathing exercises. All participants completed questionnaires validated to assess MS symptoms, including perceived mental and physical QoL (MSQOL54); fatigue (Fatigue Severity Scale, FSS; and Modified Fatigue Impact Scale, MFIS); mood (Hospital Anxiety and Depression Scale, HADS); and cognitive function (Perceived Deficits Questionnaire, PDQ).
During the 12 months, the HB group experienced improvement in scores for mental QoL (MSQOL54 - Mental, 0.24, 95% CI 0.01, 0.47; p = 0.04), fatigue (Total MFIS, -7.26, 95% CI -13.3,-1.18; p = 0.02), and perceived cognitive function (Total PDQ, PDQ-Attention, PDQ-Promemory, and PDQ-Planning, p ≤ 0.03 for all). A between-group difference was observed only for PDQ-Planning (p = 0.048). Non-inferiority analysis revealed that the 12-month changes in means for the HB group were not worse than those for the SOC group with respect to fatigue (FSS, p = 0.02), mood (HDS-Anxiety, p = 0.02; HADS-Depression, p < 0.0001), physical QoL (MSQOL54 - Physical, p = 0.02), or cognitive dysfunction (Total PDQ, p = 0.01).
The multimodal lifestyle intervention for individuals newly diagnosed with CIS or RRMS, who voluntarily decline DMTs, did not yield patient-reported outcomes worse than those observed in the SOC group regarding perceived mental quality of life, mood, fatigue, and cognitive function.
clinicaltrials.gov identifier: NCT04009005. |
doi_str_mv | 10.2147/DNND.S441738 |
format | Article |
fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10787513</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A785207389</galeid><sourcerecordid>A785207389</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-e0d76ca7c3c69243553b8118bbececa680831be39f33f066d0eb08f68d2812243</originalsourceid><addsrcrecordid>eNptUtGOEyEUnRiNu1n3zWdDYuJTp8LQzjC-mO62apNaq9X4OGGYSwdloAHa3X6s_yKTrps2ER7gXs499wAnSV4SPMzIqHg7XS6nw_VoRArKniSXhBRlWpYYPz3ZXyTX3v_CcYwZKWnxPLmgLMsyXGaXyZ-ZlCCCR1Yijr5BZwOgzzsdVGcbrtHcBHB7MEFZE4O91XtlNmiqIAzQT65_99HK2Y3j3QBx06AbBzy0fXp2D04oDyiWft1xrcKhb7NQEtCksxGxhDt9iGR8Y6yHBq3AbjWgOxXao4g-WgsNznrl36FJz-NVOrvfglNdlBUlLq1J50bGhHV9i5XSNqB12DWHF8kzybWH64f1KvnxYfb99lO6-PJxfjtZpILSIqSAmyIXvBBU5GU2ouMxrRkhrK5BgOA5w4ySGmgpKZU4zxsMNWYyZ03GSBYLrpL3R97tru6gEVGY47raRo3cHSrLVXV-YlRbbey-IrhgxZjQyPD6yLDhGiplpI040SkvqknBxhmOH1xG1PA_qDgb6JSwBqSK-bOCNycFLXAdWm_1rv9Ofw4cHIEiPrV3IB_FE1z1Vqt6q1UPVovwV6cXfgT_Mxb9C--G0gA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Effects of a Remote Multimodal Intervention Involving Diet, Walking Program, and Breathing Exercise on Quality of Life Among Newly Diagnosed People with Multiple Sclerosis: A Quasi-Experimental Non-Inferiority Pilot Study</title><source>Dove Press Free</source><source>Access via Taylor & Francis (Open Access Collection)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Saxby, Solange M ; Shemirani, Farnoosh ; Crippes, Landon J ; Ehlinger, Mary A ; Brooks, Lisa ; Bisht, Babita ; Titcomb, Tyler J ; Rubenstein, Linda M ; Eyck, Patrick Ten ; Hoth, Karin F ; Gill, Christine ; Kamholz, John ; Snetselaar, Linda G ; Wahls, Terry L</creator><creatorcontrib>Saxby, Solange M ; Shemirani, Farnoosh ; Crippes, Landon J ; Ehlinger, Mary A ; Brooks, Lisa ; Bisht, Babita ; Titcomb, Tyler J ; Rubenstein, Linda M ; Eyck, Patrick Ten ; Hoth, Karin F ; Gill, Christine ; Kamholz, John ; Snetselaar, Linda G ; Wahls, Terry L</creatorcontrib><description>Interventions involving diet, physical activity, and breathing exercises are shown to be beneficial in managing both fatigue and quality of life (QoL) related to MS; however, the impact of such interventions among people newly diagnosed with clinically isolated syndrome (CIS) or relapsing-remitting multiple sclerosis (RRMS) who decline disease-modifying therapies (DMTs) is unknown.
A 12-month prospective quasi-experimental non-inferiority trial recruited people newly diagnosed with CIS or RRMS who voluntarily declined DMTs (health behavior group; HB, n = 29) or followed standard of care (SOC, n = 15). Participants in the HB group were remotely coached on the study diet, moderate-intensity walking, and breathing exercises. All participants completed questionnaires validated to assess MS symptoms, including perceived mental and physical QoL (MSQOL54); fatigue (Fatigue Severity Scale, FSS; and Modified Fatigue Impact Scale, MFIS); mood (Hospital Anxiety and Depression Scale, HADS); and cognitive function (Perceived Deficits Questionnaire, PDQ).
During the 12 months, the HB group experienced improvement in scores for mental QoL (MSQOL54 - Mental, 0.24, 95% CI 0.01, 0.47; p = 0.04), fatigue (Total MFIS, -7.26, 95% CI -13.3,-1.18; p = 0.02), and perceived cognitive function (Total PDQ, PDQ-Attention, PDQ-Promemory, and PDQ-Planning, p ≤ 0.03 for all). A between-group difference was observed only for PDQ-Planning (p = 0.048). Non-inferiority analysis revealed that the 12-month changes in means for the HB group were not worse than those for the SOC group with respect to fatigue (FSS, p = 0.02), mood (HDS-Anxiety, p = 0.02; HADS-Depression, p < 0.0001), physical QoL (MSQOL54 - Physical, p = 0.02), or cognitive dysfunction (Total PDQ, p = 0.01).
The multimodal lifestyle intervention for individuals newly diagnosed with CIS or RRMS, who voluntarily decline DMTs, did not yield patient-reported outcomes worse than those observed in the SOC group regarding perceived mental quality of life, mood, fatigue, and cognitive function.
clinicaltrials.gov identifier: NCT04009005.</description><identifier>ISSN: 1179-9900</identifier><identifier>EISSN: 1179-9900</identifier><identifier>DOI: 10.2147/DNND.S441738</identifier><identifier>PMID: 38222092</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>Breathing exercises ; Clinical Trial Report ; Cognition disorders ; Depression, Mental ; Diet ; Fatigue ; Health aspects ; Hydrogen sulfide ; Mindfulness meditation ; Multiple sclerosis ; Physical fitness ; Walking</subject><ispartof>Degenerative neurological and neuromuscular disease, 2024-01, Vol.14, p.1-14</ispartof><rights>2024 Saxby et al.</rights><rights>COPYRIGHT 2024 Dove Medical Press Limited</rights><rights>2024 Saxby et al. 2024 Saxby et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c337t-e0d76ca7c3c69243553b8118bbececa680831be39f33f066d0eb08f68d2812243</cites><orcidid>0000-0002-5041-0708 ; 0009-0000-6930-3497 ; 0000-0002-2599-4828 ; 0000-0001-6059-7994</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10787513/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10787513/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3862,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38222092$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saxby, Solange M</creatorcontrib><creatorcontrib>Shemirani, Farnoosh</creatorcontrib><creatorcontrib>Crippes, Landon J</creatorcontrib><creatorcontrib>Ehlinger, Mary A</creatorcontrib><creatorcontrib>Brooks, Lisa</creatorcontrib><creatorcontrib>Bisht, Babita</creatorcontrib><creatorcontrib>Titcomb, Tyler J</creatorcontrib><creatorcontrib>Rubenstein, Linda M</creatorcontrib><creatorcontrib>Eyck, Patrick Ten</creatorcontrib><creatorcontrib>Hoth, Karin F</creatorcontrib><creatorcontrib>Gill, Christine</creatorcontrib><creatorcontrib>Kamholz, John</creatorcontrib><creatorcontrib>Snetselaar, Linda G</creatorcontrib><creatorcontrib>Wahls, Terry L</creatorcontrib><title>Effects of a Remote Multimodal Intervention Involving Diet, Walking Program, and Breathing Exercise on Quality of Life Among Newly Diagnosed People with Multiple Sclerosis: A Quasi-Experimental Non-Inferiority Pilot Study</title><title>Degenerative neurological and neuromuscular disease</title><addtitle>Degener Neurol Neuromuscul Dis</addtitle><description>Interventions involving diet, physical activity, and breathing exercises are shown to be beneficial in managing both fatigue and quality of life (QoL) related to MS; however, the impact of such interventions among people newly diagnosed with clinically isolated syndrome (CIS) or relapsing-remitting multiple sclerosis (RRMS) who decline disease-modifying therapies (DMTs) is unknown.
A 12-month prospective quasi-experimental non-inferiority trial recruited people newly diagnosed with CIS or RRMS who voluntarily declined DMTs (health behavior group; HB, n = 29) or followed standard of care (SOC, n = 15). Participants in the HB group were remotely coached on the study diet, moderate-intensity walking, and breathing exercises. All participants completed questionnaires validated to assess MS symptoms, including perceived mental and physical QoL (MSQOL54); fatigue (Fatigue Severity Scale, FSS; and Modified Fatigue Impact Scale, MFIS); mood (Hospital Anxiety and Depression Scale, HADS); and cognitive function (Perceived Deficits Questionnaire, PDQ).
During the 12 months, the HB group experienced improvement in scores for mental QoL (MSQOL54 - Mental, 0.24, 95% CI 0.01, 0.47; p = 0.04), fatigue (Total MFIS, -7.26, 95% CI -13.3,-1.18; p = 0.02), and perceived cognitive function (Total PDQ, PDQ-Attention, PDQ-Promemory, and PDQ-Planning, p ≤ 0.03 for all). A between-group difference was observed only for PDQ-Planning (p = 0.048). Non-inferiority analysis revealed that the 12-month changes in means for the HB group were not worse than those for the SOC group with respect to fatigue (FSS, p = 0.02), mood (HDS-Anxiety, p = 0.02; HADS-Depression, p < 0.0001), physical QoL (MSQOL54 - Physical, p = 0.02), or cognitive dysfunction (Total PDQ, p = 0.01).
The multimodal lifestyle intervention for individuals newly diagnosed with CIS or RRMS, who voluntarily decline DMTs, did not yield patient-reported outcomes worse than those observed in the SOC group regarding perceived mental quality of life, mood, fatigue, and cognitive function.
clinicaltrials.gov identifier: NCT04009005.</description><subject>Breathing exercises</subject><subject>Clinical Trial Report</subject><subject>Cognition disorders</subject><subject>Depression, Mental</subject><subject>Diet</subject><subject>Fatigue</subject><subject>Health aspects</subject><subject>Hydrogen sulfide</subject><subject>Mindfulness meditation</subject><subject>Multiple sclerosis</subject><subject>Physical fitness</subject><subject>Walking</subject><issn>1179-9900</issn><issn>1179-9900</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNptUtGOEyEUnRiNu1n3zWdDYuJTp8LQzjC-mO62apNaq9X4OGGYSwdloAHa3X6s_yKTrps2ER7gXs499wAnSV4SPMzIqHg7XS6nw_VoRArKniSXhBRlWpYYPz3ZXyTX3v_CcYwZKWnxPLmgLMsyXGaXyZ-ZlCCCR1Yijr5BZwOgzzsdVGcbrtHcBHB7MEFZE4O91XtlNmiqIAzQT65_99HK2Y3j3QBx06AbBzy0fXp2D04oDyiWft1xrcKhb7NQEtCksxGxhDt9iGR8Y6yHBq3AbjWgOxXao4g-WgsNznrl36FJz-NVOrvfglNdlBUlLq1J50bGhHV9i5XSNqB12DWHF8kzybWH64f1KvnxYfb99lO6-PJxfjtZpILSIqSAmyIXvBBU5GU2ouMxrRkhrK5BgOA5w4ySGmgpKZU4zxsMNWYyZ03GSBYLrpL3R97tru6gEVGY47raRo3cHSrLVXV-YlRbbey-IrhgxZjQyPD6yLDhGiplpI040SkvqknBxhmOH1xG1PA_qDgb6JSwBqSK-bOCNycFLXAdWm_1rv9Ofw4cHIEiPrV3IB_FE1z1Vqt6q1UPVovwV6cXfgT_Mxb9C--G0gA</recordid><startdate>20240131</startdate><enddate>20240131</enddate><creator>Saxby, Solange M</creator><creator>Shemirani, Farnoosh</creator><creator>Crippes, Landon J</creator><creator>Ehlinger, Mary A</creator><creator>Brooks, Lisa</creator><creator>Bisht, Babita</creator><creator>Titcomb, Tyler J</creator><creator>Rubenstein, Linda M</creator><creator>Eyck, Patrick Ten</creator><creator>Hoth, Karin F</creator><creator>Gill, Christine</creator><creator>Kamholz, John</creator><creator>Snetselaar, Linda G</creator><creator>Wahls, Terry L</creator><general>Dove Medical Press Limited</general><general>Dove</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5041-0708</orcidid><orcidid>https://orcid.org/0009-0000-6930-3497</orcidid><orcidid>https://orcid.org/0000-0002-2599-4828</orcidid><orcidid>https://orcid.org/0000-0001-6059-7994</orcidid></search><sort><creationdate>20240131</creationdate><title>Effects of a Remote Multimodal Intervention Involving Diet, Walking Program, and Breathing Exercise on Quality of Life Among Newly Diagnosed People with Multiple Sclerosis: A Quasi-Experimental Non-Inferiority Pilot Study</title><author>Saxby, Solange M ; Shemirani, Farnoosh ; Crippes, Landon J ; Ehlinger, Mary A ; Brooks, Lisa ; Bisht, Babita ; Titcomb, Tyler J ; Rubenstein, Linda M ; Eyck, Patrick Ten ; Hoth, Karin F ; Gill, Christine ; Kamholz, John ; Snetselaar, Linda G ; Wahls, Terry L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-e0d76ca7c3c69243553b8118bbececa680831be39f33f066d0eb08f68d2812243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Breathing exercises</topic><topic>Clinical Trial Report</topic><topic>Cognition disorders</topic><topic>Depression, Mental</topic><topic>Diet</topic><topic>Fatigue</topic><topic>Health aspects</topic><topic>Hydrogen sulfide</topic><topic>Mindfulness meditation</topic><topic>Multiple sclerosis</topic><topic>Physical fitness</topic><topic>Walking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saxby, Solange M</creatorcontrib><creatorcontrib>Shemirani, Farnoosh</creatorcontrib><creatorcontrib>Crippes, Landon J</creatorcontrib><creatorcontrib>Ehlinger, Mary A</creatorcontrib><creatorcontrib>Brooks, Lisa</creatorcontrib><creatorcontrib>Bisht, Babita</creatorcontrib><creatorcontrib>Titcomb, Tyler J</creatorcontrib><creatorcontrib>Rubenstein, Linda M</creatorcontrib><creatorcontrib>Eyck, Patrick Ten</creatorcontrib><creatorcontrib>Hoth, Karin F</creatorcontrib><creatorcontrib>Gill, Christine</creatorcontrib><creatorcontrib>Kamholz, John</creatorcontrib><creatorcontrib>Snetselaar, Linda G</creatorcontrib><creatorcontrib>Wahls, Terry L</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Degenerative neurological and neuromuscular disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saxby, Solange M</au><au>Shemirani, Farnoosh</au><au>Crippes, Landon J</au><au>Ehlinger, Mary A</au><au>Brooks, Lisa</au><au>Bisht, Babita</au><au>Titcomb, Tyler J</au><au>Rubenstein, Linda M</au><au>Eyck, Patrick Ten</au><au>Hoth, Karin F</au><au>Gill, Christine</au><au>Kamholz, John</au><au>Snetselaar, Linda G</au><au>Wahls, Terry L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of a Remote Multimodal Intervention Involving Diet, Walking Program, and Breathing Exercise on Quality of Life Among Newly Diagnosed People with Multiple Sclerosis: A Quasi-Experimental Non-Inferiority Pilot Study</atitle><jtitle>Degenerative neurological and neuromuscular disease</jtitle><addtitle>Degener Neurol Neuromuscul Dis</addtitle><date>2024-01-31</date><risdate>2024</risdate><volume>14</volume><spage>1</spage><epage>14</epage><pages>1-14</pages><issn>1179-9900</issn><eissn>1179-9900</eissn><abstract>Interventions involving diet, physical activity, and breathing exercises are shown to be beneficial in managing both fatigue and quality of life (QoL) related to MS; however, the impact of such interventions among people newly diagnosed with clinically isolated syndrome (CIS) or relapsing-remitting multiple sclerosis (RRMS) who decline disease-modifying therapies (DMTs) is unknown.
A 12-month prospective quasi-experimental non-inferiority trial recruited people newly diagnosed with CIS or RRMS who voluntarily declined DMTs (health behavior group; HB, n = 29) or followed standard of care (SOC, n = 15). Participants in the HB group were remotely coached on the study diet, moderate-intensity walking, and breathing exercises. All participants completed questionnaires validated to assess MS symptoms, including perceived mental and physical QoL (MSQOL54); fatigue (Fatigue Severity Scale, FSS; and Modified Fatigue Impact Scale, MFIS); mood (Hospital Anxiety and Depression Scale, HADS); and cognitive function (Perceived Deficits Questionnaire, PDQ).
During the 12 months, the HB group experienced improvement in scores for mental QoL (MSQOL54 - Mental, 0.24, 95% CI 0.01, 0.47; p = 0.04), fatigue (Total MFIS, -7.26, 95% CI -13.3,-1.18; p = 0.02), and perceived cognitive function (Total PDQ, PDQ-Attention, PDQ-Promemory, and PDQ-Planning, p ≤ 0.03 for all). A between-group difference was observed only for PDQ-Planning (p = 0.048). Non-inferiority analysis revealed that the 12-month changes in means for the HB group were not worse than those for the SOC group with respect to fatigue (FSS, p = 0.02), mood (HDS-Anxiety, p = 0.02; HADS-Depression, p < 0.0001), physical QoL (MSQOL54 - Physical, p = 0.02), or cognitive dysfunction (Total PDQ, p = 0.01).
The multimodal lifestyle intervention for individuals newly diagnosed with CIS or RRMS, who voluntarily decline DMTs, did not yield patient-reported outcomes worse than those observed in the SOC group regarding perceived mental quality of life, mood, fatigue, and cognitive function.
clinicaltrials.gov identifier: NCT04009005.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>38222092</pmid><doi>10.2147/DNND.S441738</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-5041-0708</orcidid><orcidid>https://orcid.org/0009-0000-6930-3497</orcidid><orcidid>https://orcid.org/0000-0002-2599-4828</orcidid><orcidid>https://orcid.org/0000-0001-6059-7994</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1179-9900 |
ispartof | Degenerative neurological and neuromuscular disease, 2024-01, Vol.14, p.1-14 |
issn | 1179-9900 1179-9900 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10787513 |
source | Dove Press Free; Access via Taylor & Francis (Open Access Collection); EZB-FREE-00999 freely available EZB journals; PubMed Central |
subjects | Breathing exercises Clinical Trial Report Cognition disorders Depression, Mental Diet Fatigue Health aspects Hydrogen sulfide Mindfulness meditation Multiple sclerosis Physical fitness Walking |
title | Effects of a Remote Multimodal Intervention Involving Diet, Walking Program, and Breathing Exercise on Quality of Life Among Newly Diagnosed People with Multiple Sclerosis: A Quasi-Experimental Non-Inferiority Pilot Study |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T14%3A42%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20a%20Remote%20Multimodal%20Intervention%20Involving%20Diet,%20Walking%20Program,%20and%20Breathing%20Exercise%20on%20Quality%20of%20Life%20Among%20Newly%20Diagnosed%20People%20with%20Multiple%20Sclerosis:%20A%20Quasi-Experimental%20Non-Inferiority%20Pilot%20Study&rft.jtitle=Degenerative%20neurological%20and%20neuromuscular%20disease&rft.au=Saxby,%20Solange%20M&rft.date=2024-01-31&rft.volume=14&rft.spage=1&rft.epage=14&rft.pages=1-14&rft.issn=1179-9900&rft.eissn=1179-9900&rft_id=info:doi/10.2147/DNND.S441738&rft_dat=%3Cgale_pubme%3EA785207389%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/38222092&rft_galeid=A785207389&rfr_iscdi=true |