Mitochondrial oxidative damage reprograms lipid metabolism of renal tubular epithelial cells in the diabetic kidney

The functional and structural changes in the proximal tubule play an important role in the occurrence and development of diabetic kidney disease (DKD). Diabetes-induced metabolic changes, including lipid metabolism reprogramming, are reported to lead to changes in the state of tubular epithelial cel...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2024-12, Vol.81 (1), p.23-23, Article 23
Hauptverfasser:	Hou, Yanjuan, Tan, Enxue, Shi, Honghong, Ren, Xiayu, Wan, Xing, Wu, Wenjie, Chen, Yiliang, Niu, Hiumin, Zhu, Guozhen, Li, Jing, Li, Yafeng, Wang, Lihua
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities aerobiosis beta oxidation Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cristae Damage accumulation Diabetes Diabetes Mellitus Diabetic Nephropathies droplets Enzymes Epithelial Cells Epithelium Glucose Homeostasis Humans Isoforms Kidney diseases Kidneys Life Sciences Lipid Metabolism Lipid peroxidation Lipids Metabolic flux Metabolic pathways Metabolic rate Metabolism Mitochondria nephroprotective effect Original Original Article Oxidation Oxidative metabolism Oxidative Stress Peroxidation Phospholipase A2 Reactive oxygen species sphingolipids Sphingosine 1-phosphate Structure-function relationships
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