Commensal Fecal Microbiota Profiles Associated with Initial Stages of Intestinal Mucosa Damage: A Pilot Study
Progressive intestinal mucosal damage occurs over years prior to colorectal cancer (CRC) development. The endoscopic screening of polyps and histopathological examination are used clinically to determine the risk and progression of mucosal lesions. We analyzed fecal microbiota compositions using 16S...
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| Veröffentlicht in: | Cancers 2023-12, Vol.16 (1), p.104 |
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| creator | Ruiz-Saavedra, Sergio Arboleya, Silvia Nogacka, Alicja M González Del Rey, Carmen Suárez, Adolfo Diaz, Ylenia Gueimonde, Miguel Salazar, Nuria González, Sonia de Los Reyes-Gavilán, Clara G |
| description | Progressive intestinal mucosal damage occurs over years prior to colorectal cancer (CRC) development. The endoscopic screening of polyps and histopathological examination are used clinically to determine the risk and progression of mucosal lesions. We analyzed fecal microbiota compositions using 16S rRNA gene-based metataxonomic analyses and the levels of short-chain fatty acids (SCFAs) using gas chromatography in volunteers undergoing colonoscopy and histopathological analyses to determine the microbiota shifts occurring at the early stages of intestinal mucosa alterations. The results were compared between diagnosis groups (nonpathological controls and polyps), between samples from individuals with hyperplastic polyps or conventional adenomas, and between grades of dysplasia in conventional adenomas. Some microbial taxa from the
and
phyla were the most affected when comparing the diagnosis and histopathological groups. Deeper microbiota alterations were found in the conventional adenomas than in the hyperplastic polyps. The
group was enriched in both the hyperplastic polyps and conventional adenomas, whereas the family
was enriched only in the hyperplastic polyps. The abundance of
,
,
,
,
,
, and
shifted in conventional adenomas depending on the grade of dysplasia, without affecting the major SCFAs. Our results suggest a reorganization of microbial consortia involved in gut fermentative processes. |
| doi_str_mv | 10.3390/cancers16010104 |
| format | Article |
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and
phyla were the most affected when comparing the diagnosis and histopathological groups. Deeper microbiota alterations were found in the conventional adenomas than in the hyperplastic polyps. The
group was enriched in both the hyperplastic polyps and conventional adenomas, whereas the family
was enriched only in the hyperplastic polyps. The abundance of
,
,
,
,
,
, and
shifted in conventional adenomas depending on the grade of dysplasia, without affecting the major SCFAs. Our results suggest a reorganization of microbial consortia involved in gut fermentative processes.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers16010104</identifier><identifier>PMID: 38201530</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adenoma ; Amino acids ; Bar codes ; Bioethics ; Cancer ; Chromatography ; Colonoscopy ; Colorectal cancer ; Colorectal carcinoma ; Comparative analysis ; Development and progression ; Diagnosis ; Dysbacteriosis ; Dysplasia ; Fatty acids ; Fecal microflora ; Feces ; Gas chromatography ; Health aspects ; Intestinal microflora ; Intestine ; Microbiota ; Microbiota (Symbiotic organisms) ; Morphology ; Mortality ; Mucosa ; Oncology, Experimental ; Pilot projects ; Polyps ; RNA ; rRNA 16S ; Software ; Spain ; Tumors ; Variables</subject><ispartof>Cancers, 2023-12, Vol.16 (1), p.104</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-df824e88eebc57906ca1736113e782f95fc503e4575dd6254ec9f237c46f29773</citedby><cites>FETCH-LOGICAL-c489t-df824e88eebc57906ca1736113e782f95fc503e4575dd6254ec9f237c46f29773</cites><orcidid>0000-0002-6834-9060 ; 0000-0002-0192-901X ; 0000-0003-1435-7628 ; 0000-0003-2602-7036 ; 0000-0001-8300-6149 ; 0000-0001-9396-6311 ; 0000-0002-6155-5822 ; 0000-0001-7149-6814</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10778549/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10778549/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38201530$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruiz-Saavedra, Sergio</creatorcontrib><creatorcontrib>Arboleya, Silvia</creatorcontrib><creatorcontrib>Nogacka, Alicja M</creatorcontrib><creatorcontrib>González Del Rey, Carmen</creatorcontrib><creatorcontrib>Suárez, Adolfo</creatorcontrib><creatorcontrib>Diaz, Ylenia</creatorcontrib><creatorcontrib>Gueimonde, Miguel</creatorcontrib><creatorcontrib>Salazar, Nuria</creatorcontrib><creatorcontrib>González, Sonia</creatorcontrib><creatorcontrib>de Los Reyes-Gavilán, Clara G</creatorcontrib><title>Commensal Fecal Microbiota Profiles Associated with Initial Stages of Intestinal Mucosa Damage: A Pilot Study</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Progressive intestinal mucosal damage occurs over years prior to colorectal cancer (CRC) development. The endoscopic screening of polyps and histopathological examination are used clinically to determine the risk and progression of mucosal lesions. We analyzed fecal microbiota compositions using 16S rRNA gene-based metataxonomic analyses and the levels of short-chain fatty acids (SCFAs) using gas chromatography in volunteers undergoing colonoscopy and histopathological analyses to determine the microbiota shifts occurring at the early stages of intestinal mucosa alterations. The results were compared between diagnosis groups (nonpathological controls and polyps), between samples from individuals with hyperplastic polyps or conventional adenomas, and between grades of dysplasia in conventional adenomas. Some microbial taxa from the
and
phyla were the most affected when comparing the diagnosis and histopathological groups. Deeper microbiota alterations were found in the conventional adenomas than in the hyperplastic polyps. The
group was enriched in both the hyperplastic polyps and conventional adenomas, whereas the family
was enriched only in the hyperplastic polyps. The abundance of
,
,
,
,
,
, and
shifted in conventional adenomas depending on the grade of dysplasia, without affecting the major SCFAs. Our results suggest a reorganization of microbial consortia involved in gut fermentative processes.</description><subject>Adenoma</subject><subject>Amino acids</subject><subject>Bar codes</subject><subject>Bioethics</subject><subject>Cancer</subject><subject>Chromatography</subject><subject>Colonoscopy</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Comparative analysis</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Dysbacteriosis</subject><subject>Dysplasia</subject><subject>Fatty acids</subject><subject>Fecal microflora</subject><subject>Feces</subject><subject>Gas chromatography</subject><subject>Health aspects</subject><subject>Intestinal microflora</subject><subject>Intestine</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Morphology</subject><subject>Mortality</subject><subject>Mucosa</subject><subject>Oncology, Experimental</subject><subject>Pilot projects</subject><subject>Polyps</subject><subject>RNA</subject><subject>rRNA 16S</subject><subject>Software</subject><subject>Spain</subject><subject>Tumors</subject><subject>Variables</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptks9vFCEUx4nR2Gbt2ZuZxIuXbfk5gBezWa02qbGJeiYs89jSzEAFRtP_vmxba9vIS4DwPu9L3g-EXhN8yJjGR85GB7mQHpNm_Bnap1jSZd9r_vzBfQ8dlHKB22KMyF6-RHtMUUwEw_toWqdpgljs2B2Da_vX4HLahFRtd5aTDyOUblVKcsFWGLo_oZ53JzHU0Njv1W6bO_n2UqHUEHcCs0vFdh_t1Jzvu1V3FsZUGzsPV6_QC2_HAgd35wL9PP70Y_1lefrt88l6dbp0XOm6HLyiHJQC2DghNe6dJZL1hDCQinotvBOYARdSDENPBQenPWXS8d5TLSVboA-3upfzZoLBQazZjuYyh8nmK5NsMI89MZybbfptCJZSCa6bwrs7hZx-zS03M4XiYBxthDQXQzVhnCvMVUPfPkEv0pxbKW4oKihVQv-jtnYEE6JP7WO3EzUrKZsa5S2_BTr8D9VsgCm4FGHXkMcBR7cBrWulZPD3SRJsdlNinkxJi3jzsDb3_N-ZYNdDC7e8</recordid><startdate>20231224</startdate><enddate>20231224</enddate><creator>Ruiz-Saavedra, Sergio</creator><creator>Arboleya, Silvia</creator><creator>Nogacka, Alicja M</creator><creator>González Del Rey, Carmen</creator><creator>Suárez, Adolfo</creator><creator>Diaz, Ylenia</creator><creator>Gueimonde, Miguel</creator><creator>Salazar, Nuria</creator><creator>González, Sonia</creator><creator>de Los Reyes-Gavilán, Clara G</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6834-9060</orcidid><orcidid>https://orcid.org/0000-0002-0192-901X</orcidid><orcidid>https://orcid.org/0000-0003-1435-7628</orcidid><orcidid>https://orcid.org/0000-0003-2602-7036</orcidid><orcidid>https://orcid.org/0000-0001-8300-6149</orcidid><orcidid>https://orcid.org/0000-0001-9396-6311</orcidid><orcidid>https://orcid.org/0000-0002-6155-5822</orcidid><orcidid>https://orcid.org/0000-0001-7149-6814</orcidid></search><sort><creationdate>20231224</creationdate><title>Commensal Fecal Microbiota Profiles Associated with Initial Stages of Intestinal Mucosa Damage: A Pilot Study</title><author>Ruiz-Saavedra, Sergio ; Arboleya, Silvia ; Nogacka, Alicja M ; González Del Rey, Carmen ; Suárez, Adolfo ; Diaz, Ylenia ; Gueimonde, Miguel ; Salazar, Nuria ; González, Sonia ; de Los Reyes-Gavilán, Clara G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-df824e88eebc57906ca1736113e782f95fc503e4575dd6254ec9f237c46f29773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adenoma</topic><topic>Amino acids</topic><topic>Bar codes</topic><topic>Bioethics</topic><topic>Cancer</topic><topic>Chromatography</topic><topic>Colonoscopy</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Comparative analysis</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Dysbacteriosis</topic><topic>Dysplasia</topic><topic>Fatty acids</topic><topic>Fecal microflora</topic><topic>Feces</topic><topic>Gas chromatography</topic><topic>Health aspects</topic><topic>Intestinal microflora</topic><topic>Intestine</topic><topic>Microbiota</topic><topic>Microbiota (Symbiotic organisms)</topic><topic>Morphology</topic><topic>Mortality</topic><topic>Mucosa</topic><topic>Oncology, Experimental</topic><topic>Pilot projects</topic><topic>Polyps</topic><topic>RNA</topic><topic>rRNA 16S</topic><topic>Software</topic><topic>Spain</topic><topic>Tumors</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruiz-Saavedra, Sergio</creatorcontrib><creatorcontrib>Arboleya, Silvia</creatorcontrib><creatorcontrib>Nogacka, Alicja M</creatorcontrib><creatorcontrib>González Del Rey, Carmen</creatorcontrib><creatorcontrib>Suárez, Adolfo</creatorcontrib><creatorcontrib>Diaz, Ylenia</creatorcontrib><creatorcontrib>Gueimonde, Miguel</creatorcontrib><creatorcontrib>Salazar, Nuria</creatorcontrib><creatorcontrib>González, Sonia</creatorcontrib><creatorcontrib>de Los Reyes-Gavilán, Clara G</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruiz-Saavedra, Sergio</au><au>Arboleya, Silvia</au><au>Nogacka, Alicja M</au><au>González Del Rey, Carmen</au><au>Suárez, Adolfo</au><au>Diaz, Ylenia</au><au>Gueimonde, Miguel</au><au>Salazar, Nuria</au><au>González, Sonia</au><au>de Los Reyes-Gavilán, Clara G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Commensal Fecal Microbiota Profiles Associated with Initial Stages of Intestinal Mucosa Damage: A Pilot Study</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2023-12-24</date><risdate>2023</risdate><volume>16</volume><issue>1</issue><spage>104</spage><pages>104-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Progressive intestinal mucosal damage occurs over years prior to colorectal cancer (CRC) development. The endoscopic screening of polyps and histopathological examination are used clinically to determine the risk and progression of mucosal lesions. We analyzed fecal microbiota compositions using 16S rRNA gene-based metataxonomic analyses and the levels of short-chain fatty acids (SCFAs) using gas chromatography in volunteers undergoing colonoscopy and histopathological analyses to determine the microbiota shifts occurring at the early stages of intestinal mucosa alterations. The results were compared between diagnosis groups (nonpathological controls and polyps), between samples from individuals with hyperplastic polyps or conventional adenomas, and between grades of dysplasia in conventional adenomas. Some microbial taxa from the
and
phyla were the most affected when comparing the diagnosis and histopathological groups. Deeper microbiota alterations were found in the conventional adenomas than in the hyperplastic polyps. The
group was enriched in both the hyperplastic polyps and conventional adenomas, whereas the family
was enriched only in the hyperplastic polyps. The abundance of
,
,
,
,
,
, and
shifted in conventional adenomas depending on the grade of dysplasia, without affecting the major SCFAs. Our results suggest a reorganization of microbial consortia involved in gut fermentative processes.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38201530</pmid><doi>10.3390/cancers16010104</doi><orcidid>https://orcid.org/0000-0002-6834-9060</orcidid><orcidid>https://orcid.org/0000-0002-0192-901X</orcidid><orcidid>https://orcid.org/0000-0003-1435-7628</orcidid><orcidid>https://orcid.org/0000-0003-2602-7036</orcidid><orcidid>https://orcid.org/0000-0001-8300-6149</orcidid><orcidid>https://orcid.org/0000-0001-9396-6311</orcidid><orcidid>https://orcid.org/0000-0002-6155-5822</orcidid><orcidid>https://orcid.org/0000-0001-7149-6814</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancers, 2023-12, Vol.16 (1), p.104 |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Adenoma Amino acids Bar codes Bioethics Cancer Chromatography Colonoscopy Colorectal cancer Colorectal carcinoma Comparative analysis Development and progression Diagnosis Dysbacteriosis Dysplasia Fatty acids Fecal microflora Feces Gas chromatography Health aspects Intestinal microflora Intestine Microbiota Microbiota (Symbiotic organisms) Morphology Mortality Mucosa Oncology, Experimental Pilot projects Polyps RNA rRNA 16S Software Spain Tumors Variables |
| title | Commensal Fecal Microbiota Profiles Associated with Initial Stages of Intestinal Mucosa Damage: A Pilot Study |
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