Enantioselective Amination of 4‑Substituted Pyrazolones Catalyzed by Oxindole-Containing Thioureas and by a Recyclable Linear-Polymer-Supported Analogue in a Continuous Flow Process

A highly efficient organocatalytic amination of 4-substituted pyrazolones with azodicarboxylates mediated by a novel quinine-derived thiourea with a 3,3-diaryl-oxindole scaffold is reported. This synthetic method furnished 4-amino-5-pyrazolones in high yields and with excellent enantioselectivities...

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Veröffentlicht in:	Journal of organic chemistry 2024-01, Vol.89 (1), p.330-344
Hauptverfasser:	Sánchez-Molpeceres, Rodrigo, Martín, Laura, Esteban, Noelia, Miguel, Jesús A., Maestro, Alicia, Andrés, José M.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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