Codiversification of gut microbiota with humans
The gut microbiomes of human populations worldwide have many core microbial species in common. However, within a species, some strains can show remarkable population specificity. The question is whether such specificity arises from a shared evolutionary history (codiversification) between humans and...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2022-09, Vol.377 (6612), p.1328-1332 |
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| creator | Suzuki, Taichi A Fitzstevens, J Liam Schmidt, Victor T Enav, Hagay Huus, Kelsey E Mbong Ngwese, Mirabeau Grießhammer, Anne Pfleiderer, Anne Adegbite, Bayode R Zinsou, Jeannot F Esen, Meral Velavan, Thirumalaisamy P Adegnika, Ayola A Song, Le Huu Spector, Timothy D Muehlbauer, Amanda L Marchi, Nina Kang, Hyena Maier, Lisa Blekhman, Ran Ségurel, Laure Ko, GwangPyo Youngblut, Nicholas D Kremsner, Peter Ley, Ruth E |
| description | The gut microbiomes of human populations worldwide have many core microbial species in common. However, within a species, some strains can show remarkable population specificity. The question is whether such specificity arises from a shared evolutionary history (codiversification) between humans and their microbes. To test for codiversification of host and microbiota, we analyzed paired gut metagenomes and human genomes for 1225 individuals in Europe, Asia, and Africa, including mothers and their children. Between and within countries, a parallel evolutionary history was evident for humans and their gut microbes. Moreover, species displaying the strongest codiversification independently evolved traits characteristic of host dependency, including reduced genomes and oxygen and temperature sensitivity. These findings all point to the importance of understanding the potential role of population-specific microbial strains in microbiome-mediated disease phenotypes. |
| doi_str_mv | 10.1126/science.abm7759 |
| format | Article |
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However, within a species, some strains can show remarkable population specificity. The question is whether such specificity arises from a shared evolutionary history (codiversification) between humans and their microbes. To test for codiversification of host and microbiota, we analyzed paired gut metagenomes and human genomes for 1225 individuals in Europe, Asia, and Africa, including mothers and their children. Between and within countries, a parallel evolutionary history was evident for humans and their gut microbes. Moreover, species displaying the strongest codiversification independently evolved traits characteristic of host dependency, including reduced genomes and oxygen and temperature sensitivity. 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However, within a species, some strains can show remarkable population specificity. The question is whether such specificity arises from a shared evolutionary history (codiversification) between humans and their microbes. To test for codiversification of host and microbiota, we analyzed paired gut metagenomes and human genomes for 1225 individuals in Europe, Asia, and Africa, including mothers and their children. Between and within countries, a parallel evolutionary history was evident for humans and their gut microbes. Moreover, species displaying the strongest codiversification independently evolved traits characteristic of host dependency, including reduced genomes and oxygen and temperature sensitivity. 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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2022-09, Vol.377 (6612), p.1328-1332 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10777373 |
| source | American Association for the Advancement of Science; MEDLINE |
| subjects | Bacteria - classification Bacteria - genetics Child Gastrointestinal Microbiome - genetics Genetics Genomes Host Microbial Interactions Human populations Humans Intestinal microflora Intolerance Life Sciences Metagenome Microbiomes Microbiota Microorganisms Migration Oxygen - metabolism Populations and Evolution Strains (organisms) |
| title | Codiversification of gut microbiota with humans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T17%3A32%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Codiversification%20of%20gut%20microbiota%20with%20humans&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Suzuki,%20Taichi%20A&rft.date=2022-09-16&rft.volume=377&rft.issue=6612&rft.spage=1328&rft.epage=1332&rft.pages=1328-1332&rft.issn=0036-8075&rft.eissn=1095-9203&rft_id=info:doi/10.1126/science.abm7759&rft_dat=%3Cproquest_pubme%3E2714932989%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2714932989&rft_id=info:pmid/36108023&rfr_iscdi=true |