Intermuscular Coherence in Spinocerebellar Ataxias 3 and 6: a Preliminary Study
Spinocerebellar ataxias (SCAs) are familial neurodegenerative diseases involving the cerebellum and spinocerebellar tracts. While there is variable involvement of corticospinal tracts (CST), dorsal root ganglia, and motor neurons in SCA3, SCA6 is characterized by a pure, late-onset ataxia. Abnormal...
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| Veröffentlicht in: | Cerebellum (London, England) England), 2024-04, Vol.23 (2), p.601-608 |
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| creator | Issa, Naoum P. Aydin, Serdar Bhatnagar, Shail Baumgartner, Nicholas W. Hill, Jacquelyn Aluri, Sravya Valentic, Chloe S. Polley, Eric Gomez, Christopher M. Rezania, Kourosh |
| description | Spinocerebellar ataxias (SCAs) are familial neurodegenerative diseases involving the cerebellum and spinocerebellar tracts. While there is variable involvement of corticospinal tracts (CST), dorsal root ganglia, and motor neurons in SCA3, SCA6 is characterized by a pure, late-onset ataxia. Abnormal intermuscular coherence in the beta-gamma frequency range (IMCβγ) implies a lack of integrity of CST or the afferent input from the acting muscles. We test the hypothesis that IMCβγ has the potential to be a biomarker of disease activity in SCA3 but not SCA6. Intermuscular coherence between biceps brachii and brachioradialis muscles was measured from surface EMG waveforms in SCA3 (
N
= 16) and SCA6 (
N
= 20) patients and in neurotypical subjects (
N
= 23). IMC peak frequencies were present in the β range in SCA patients and in the γ range in neurotypical subjects. The difference between IMC amplitudes in the γ and β ranges was significant when comparing neurotypical control subjects to SCA3 (
p
< 0.01) and SCA6 (
p
= 0.01) patients. IMCβγ amplitude was smaller in SCA3 patients compared to neurotypical subjects (
p
< 0.05), but not different between SCA3 and SCA6 patients or between SCA6 and neurotypical subjects. IMC metrics can differentiate SCA patients from normal controls. |
| doi_str_mv | 10.1007/s12311-023-01585-7 |
| format | Article |
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N
= 16) and SCA6 (
N
= 20) patients and in neurotypical subjects (
N
= 23). IMC peak frequencies were present in the β range in SCA patients and in the γ range in neurotypical subjects. The difference between IMC amplitudes in the γ and β ranges was significant when comparing neurotypical control subjects to SCA3 (
p
< 0.01) and SCA6 (
p
= 0.01) patients. IMCβγ amplitude was smaller in SCA3 patients compared to neurotypical subjects (
p
< 0.05), but not different between SCA3 and SCA6 patients or between SCA6 and neurotypical subjects. IMC metrics can differentiate SCA patients from normal controls.</description><identifier>ISSN: 1473-4230</identifier><identifier>ISSN: 1473-4222</identifier><identifier>EISSN: 1473-4230</identifier><identifier>DOI: 10.1007/s12311-023-01585-7</identifier><identifier>PMID: 37428409</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Amyotrophic lateral sclerosis ; Ataxia ; Biomarkers ; Biomedical and Life Sciences ; Biomedicine ; Cerebellum ; Clinical trials ; Disease ; Dorsal root ganglia ; Electromyography ; Genetic testing ; Humans ; Longitudinal studies ; Machado-Joseph Disease ; Motor neurons ; Muscles ; Neurobiology ; Neurodegenerative diseases ; Neurology ; Neurons ; Neurosciences ; Pyramidal tracts ; Sensory neurons ; Spinocerebellar ataxia ; Spinocerebellar Ataxias ; Transcranial magnetic stimulation ; Volumetric analysis</subject><ispartof>Cerebellum (London, England), 2024-04, Vol.23 (2), p.601-608</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-314ba8e4ea93b03fbd8e8b4d3123351f98c1a1003bb84530df13f59ea6f36423</citedby><cites>FETCH-LOGICAL-c475t-314ba8e4ea93b03fbd8e8b4d3123351f98c1a1003bb84530df13f59ea6f36423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12311-023-01585-7$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12311-023-01585-7$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37428409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Issa, Naoum P.</creatorcontrib><creatorcontrib>Aydin, Serdar</creatorcontrib><creatorcontrib>Bhatnagar, Shail</creatorcontrib><creatorcontrib>Baumgartner, Nicholas W.</creatorcontrib><creatorcontrib>Hill, Jacquelyn</creatorcontrib><creatorcontrib>Aluri, Sravya</creatorcontrib><creatorcontrib>Valentic, Chloe S.</creatorcontrib><creatorcontrib>Polley, Eric</creatorcontrib><creatorcontrib>Gomez, Christopher M.</creatorcontrib><creatorcontrib>Rezania, Kourosh</creatorcontrib><title>Intermuscular Coherence in Spinocerebellar Ataxias 3 and 6: a Preliminary Study</title><title>Cerebellum (London, England)</title><addtitle>Cerebellum</addtitle><addtitle>Cerebellum</addtitle><description>Spinocerebellar ataxias (SCAs) are familial neurodegenerative diseases involving the cerebellum and spinocerebellar tracts. While there is variable involvement of corticospinal tracts (CST), dorsal root ganglia, and motor neurons in SCA3, SCA6 is characterized by a pure, late-onset ataxia. Abnormal intermuscular coherence in the beta-gamma frequency range (IMCβγ) implies a lack of integrity of CST or the afferent input from the acting muscles. We test the hypothesis that IMCβγ has the potential to be a biomarker of disease activity in SCA3 but not SCA6. Intermuscular coherence between biceps brachii and brachioradialis muscles was measured from surface EMG waveforms in SCA3 (
N
= 16) and SCA6 (
N
= 20) patients and in neurotypical subjects (
N
= 23). IMC peak frequencies were present in the β range in SCA patients and in the γ range in neurotypical subjects. The difference between IMC amplitudes in the γ and β ranges was significant when comparing neurotypical control subjects to SCA3 (
p
< 0.01) and SCA6 (
p
= 0.01) patients. IMCβγ amplitude was smaller in SCA3 patients compared to neurotypical subjects (
p
< 0.05), but not different between SCA3 and SCA6 patients or between SCA6 and neurotypical subjects. IMC metrics can differentiate SCA patients from normal controls.</description><subject>Amyotrophic lateral sclerosis</subject><subject>Ataxia</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cerebellum</subject><subject>Clinical trials</subject><subject>Disease</subject><subject>Dorsal root ganglia</subject><subject>Electromyography</subject><subject>Genetic testing</subject><subject>Humans</subject><subject>Longitudinal studies</subject><subject>Machado-Joseph Disease</subject><subject>Motor neurons</subject><subject>Muscles</subject><subject>Neurobiology</subject><subject>Neurodegenerative diseases</subject><subject>Neurology</subject><subject>Neurons</subject><subject>Neurosciences</subject><subject>Pyramidal tracts</subject><subject>Sensory neurons</subject><subject>Spinocerebellar ataxia</subject><subject>Spinocerebellar Ataxias</subject><subject>Transcranial magnetic stimulation</subject><subject>Volumetric analysis</subject><issn>1473-4230</issn><issn>1473-4222</issn><issn>1473-4230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9UUtLxDAYDKK46-MPeJCAFy_VvNqkXkQWX7CgoPeQtl81S5uuSSv6701d3wdPSZjJfDPfILRHyRElRB4HyjilCWE8ITRVaSLX0JQKyRPBOFn_cZ-grRAWhDBGhNxEEy4FU4LkU3Rz7Xrw7RDKoTEez7pH8OBKwNbhu6V1XRnfBTQjeNabF2sC5ti4Cmcn2OBbD41trTP-Fd_1Q_W6gzZq0wTY_Ti30f3F-f3sKpnfXF7PzuZJKWTaJ5yKwigQYHJeEF4XlQJViIrHSDylda5KamJIXhRKpJxUNeV1moPJap7FRNvodCW7HIoWqhJc702jl9620YrujNW_EWcf9UP3rCmRMlNURoXDDwXfPQ0Qet3aUI5BHXRD0ON-mEgZU5F68Ie66AbvYjzN8kxJFtdJIoutWKXvQvBQf7mhRI996VVfOval3_vSo4v9nzm-vnwWFAl8RQgRcg_gv2f_I_sG7Myf8g</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Issa, Naoum P.</creator><creator>Aydin, Serdar</creator><creator>Bhatnagar, Shail</creator><creator>Baumgartner, Nicholas W.</creator><creator>Hill, Jacquelyn</creator><creator>Aluri, Sravya</creator><creator>Valentic, Chloe S.</creator><creator>Polley, Eric</creator><creator>Gomez, Christopher M.</creator><creator>Rezania, Kourosh</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240401</creationdate><title>Intermuscular Coherence in Spinocerebellar Ataxias 3 and 6: a Preliminary Study</title><author>Issa, Naoum P. ; Aydin, Serdar ; Bhatnagar, Shail ; Baumgartner, Nicholas W. ; Hill, Jacquelyn ; Aluri, Sravya ; Valentic, Chloe S. ; Polley, Eric ; Gomez, Christopher M. ; Rezania, Kourosh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-314ba8e4ea93b03fbd8e8b4d3123351f98c1a1003bb84530df13f59ea6f36423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Amyotrophic lateral sclerosis</topic><topic>Ataxia</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cerebellum</topic><topic>Clinical trials</topic><topic>Disease</topic><topic>Dorsal root ganglia</topic><topic>Electromyography</topic><topic>Genetic testing</topic><topic>Humans</topic><topic>Longitudinal studies</topic><topic>Machado-Joseph Disease</topic><topic>Motor neurons</topic><topic>Muscles</topic><topic>Neurobiology</topic><topic>Neurodegenerative diseases</topic><topic>Neurology</topic><topic>Neurons</topic><topic>Neurosciences</topic><topic>Pyramidal tracts</topic><topic>Sensory neurons</topic><topic>Spinocerebellar ataxia</topic><topic>Spinocerebellar Ataxias</topic><topic>Transcranial magnetic stimulation</topic><topic>Volumetric analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Issa, Naoum P.</creatorcontrib><creatorcontrib>Aydin, Serdar</creatorcontrib><creatorcontrib>Bhatnagar, Shail</creatorcontrib><creatorcontrib>Baumgartner, Nicholas W.</creatorcontrib><creatorcontrib>Hill, Jacquelyn</creatorcontrib><creatorcontrib>Aluri, Sravya</creatorcontrib><creatorcontrib>Valentic, Chloe S.</creatorcontrib><creatorcontrib>Polley, Eric</creatorcontrib><creatorcontrib>Gomez, Christopher M.</creatorcontrib><creatorcontrib>Rezania, Kourosh</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cerebellum (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Issa, Naoum P.</au><au>Aydin, Serdar</au><au>Bhatnagar, Shail</au><au>Baumgartner, Nicholas W.</au><au>Hill, Jacquelyn</au><au>Aluri, Sravya</au><au>Valentic, Chloe S.</au><au>Polley, Eric</au><au>Gomez, Christopher M.</au><au>Rezania, Kourosh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intermuscular Coherence in Spinocerebellar Ataxias 3 and 6: a Preliminary Study</atitle><jtitle>Cerebellum (London, England)</jtitle><stitle>Cerebellum</stitle><addtitle>Cerebellum</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>23</volume><issue>2</issue><spage>601</spage><epage>608</epage><pages>601-608</pages><issn>1473-4230</issn><issn>1473-4222</issn><eissn>1473-4230</eissn><abstract>Spinocerebellar ataxias (SCAs) are familial neurodegenerative diseases involving the cerebellum and spinocerebellar tracts. While there is variable involvement of corticospinal tracts (CST), dorsal root ganglia, and motor neurons in SCA3, SCA6 is characterized by a pure, late-onset ataxia. Abnormal intermuscular coherence in the beta-gamma frequency range (IMCβγ) implies a lack of integrity of CST or the afferent input from the acting muscles. We test the hypothesis that IMCβγ has the potential to be a biomarker of disease activity in SCA3 but not SCA6. Intermuscular coherence between biceps brachii and brachioradialis muscles was measured from surface EMG waveforms in SCA3 (
N
= 16) and SCA6 (
N
= 20) patients and in neurotypical subjects (
N
= 23). IMC peak frequencies were present in the β range in SCA patients and in the γ range in neurotypical subjects. The difference between IMC amplitudes in the γ and β ranges was significant when comparing neurotypical control subjects to SCA3 (
p
< 0.01) and SCA6 (
p
= 0.01) patients. IMCβγ amplitude was smaller in SCA3 patients compared to neurotypical subjects (
p
< 0.05), but not different between SCA3 and SCA6 patients or between SCA6 and neurotypical subjects. IMC metrics can differentiate SCA patients from normal controls.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>37428409</pmid><doi>10.1007/s12311-023-01585-7</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amyotrophic lateral sclerosis Ataxia Biomarkers Biomedical and Life Sciences Biomedicine Cerebellum Clinical trials Disease Dorsal root ganglia Electromyography Genetic testing Humans Longitudinal studies Machado-Joseph Disease Motor neurons Muscles Neurobiology Neurodegenerative diseases Neurology Neurons Neurosciences Pyramidal tracts Sensory neurons Spinocerebellar ataxia Spinocerebellar Ataxias Transcranial magnetic stimulation Volumetric analysis |
| title | Intermuscular Coherence in Spinocerebellar Ataxias 3 and 6: a Preliminary Study |
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