Regulating mitochondrial metabolism by targeting pyruvate dehydrogenase with dichloroacetate, a metabolic messenger

Dichloroacetate (DCA) is a naturally occurring xenobiotic that has been used as an investigational drug for over 50 years. Originally found to lower blood glucose levels and alter fat metabolism in diabetic rats, this small molecule was found to serve primarily as a pyruvate dehydrogenase kinase inh...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2023-10, Vol.1869 (7), p.166769-166769, Article 166769
Hauptverfasser:	Schoenmann, Nick, Tannenbaum, Nicholas, Hodgeman, Ryan M., Raju, Raghavan Pillai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diabetes Mellitus, Experimental Dichloroacetate Energetics Glycolysis Lactic acidosis Mitochondria Oxidoreductases Pyruvate Dehydrogenase Acetyl-Transferring Kinase Pyruvate Dehydrogenase Complex - metabolism Pyruvic Acid - metabolism Rats
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