Junctional Ectopic Tachycardia Caused by Junctophilin-2 Expression Silencing Is Selectively Sensitive to Ryanodine Receptor Blockade

Junctional ectopic tachycardia (JET) is a potentially fatal cardiac arrhythmia. Hcn4:shJph2 mice serve as a model of nodal arrhythmias driven by ryanodine type 2 receptor (RyR2)-mediated Ca leak. EL20 is a small molecule that blocks RyR2 Ca leak. In a novel in vivo model of JET, Hcn4:shJph2 mice dem...

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Veröffentlicht in:	JACC. Basic to translational science 2023-12, Vol.8 (12), p.1577-1588
Hauptverfasser:	Yang, Qixin, Tadros, Hanna J, Sun, Bo, Bidzimou, Minu-Tshyeto, Ezekian, Jordan E, Li, Feng, Ludwig, Andreas, Wehrens, Xander H T, Landstrom, Andrew P
Format:	Artikel
Sprache:	eng
Schlagworte:	Original Research - Preclinical
Online-Zugang:	Volltext
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