Human milk oligosaccharides and the association with microbiota in colostrum: a pilot study
HMOs (Human milk oligosaccharide) has an impact on maternal and infant health. Colostrum samples of 70 breastfeeding women in China were collected and recorded clinical characteristics. The major oligosaccharides and microbiota were quantitated in colostrum. The concentration of fucosylated HMOs in...
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| Veröffentlicht in: | Archives of microbiology 2024-02, Vol.206 (2), p.58-58, Article 58 |
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| creator | Sun, Wen Tao, Lin Qian, Chen Xue, Peipei Tong, Xiankun Yang, Li Lu, Fang Wan, Hua Tao, Yingna |
| description | HMOs (Human milk oligosaccharide) has an impact on maternal and infant health. Colostrum samples of 70 breastfeeding women in China were collected and recorded clinical characteristics. The major oligosaccharides and microbiota were quantitated in colostrum. The concentration of fucosylated HMOs in primipara was higher than that of multipara (
p
= 0.030). The concentration of N-acetylated HMOs in vaginal delivery milk was less than that of cesarean (
p
= 0.038). Non-fucosylated HMOs of breastfeeding women were less than that of breast pump (
p
= 0.038). Meanwhile, the concentration of LNT was positively correlated with
Lactobacillus
(
r
= 0.250,
p
= 0.037). DS-LNT was negatively correlated with
Staphylococcus
(
r
= – 0.240,
p
= 0.045). There was a positive correlation of
Streptococcus
with LNFP II (
r
= 0.314,
p
= 0.011) and 3-SL (
r
= 0.322,
p
= 0.009). In addition, there was a negative correlation between 2'-FL and 3-FL (
r
= – 0.465,
p
= 0.001). There was a positive correlation between LNT and LNnT (
r
= 0.778,
p
= 0.001). Therefore, the concentration of HMOs is related to number of deliveries, delivery mode, lactation mode and perinatal antibiotic. The concentration of HMOs is related to
Lactobacillus
,
Streptococcus
and
Streptococcus
in colostrum. In addition, there are connections between different oligosaccharides in content. The study protocol was also registered in the ClinicalTrails.gov (ChiCTR2200064454) (Oct. 2022). |
| doi_str_mv | 10.1007/s00203-023-03787-3 |
| format | Article |
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p
= 0.030). The concentration of N-acetylated HMOs in vaginal delivery milk was less than that of cesarean (
p
= 0.038). Non-fucosylated HMOs of breastfeeding women were less than that of breast pump (
p
= 0.038). Meanwhile, the concentration of LNT was positively correlated with
Lactobacillus
(
r
= 0.250,
p
= 0.037). DS-LNT was negatively correlated with
Staphylococcus
(
r
= – 0.240,
p
= 0.045). There was a positive correlation of
Streptococcus
with LNFP II (
r
= 0.314,
p
= 0.011) and 3-SL (
r
= 0.322,
p
= 0.009). In addition, there was a negative correlation between 2'-FL and 3-FL (
r
= – 0.465,
p
= 0.001). There was a positive correlation between LNT and LNnT (
r
= 0.778,
p
= 0.001). Therefore, the concentration of HMOs is related to number of deliveries, delivery mode, lactation mode and perinatal antibiotic. The concentration of HMOs is related to
Lactobacillus
,
Streptococcus
and
Streptococcus
in colostrum. In addition, there are connections between different oligosaccharides in content. The study protocol was also registered in the ClinicalTrails.gov (ChiCTR2200064454) (Oct. 2022).</description><identifier>ISSN: 0302-8933</identifier><identifier>ISSN: 1432-072X</identifier><identifier>EISSN: 1432-072X</identifier><identifier>DOI: 10.1007/s00203-023-03787-3</identifier><identifier>PMID: 38191870</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>antibiotics ; Bacteria ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Breast feeding ; Breast milk ; Breastfeeding & lactation ; breasts ; Cell Biology ; China ; Colostrum ; Correlation ; Ecology ; Female ; Humans ; Infant ; Lactation ; Lactobacillus ; Life Sciences ; Microbial Ecology ; Microbiology ; Microbiota ; Microorganisms ; Milk ; Milk, Human ; Oligosaccharides ; Original Paper ; Pilot Projects ; Pregnancy ; Staphylococcus ; Streptococcus</subject><ispartof>Archives of microbiology, 2024-02, Vol.206 (2), p.58-58, Article 58</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c459t-82dd2f7e00da3ed5b9e0ef3146bf0b9121bea2d5c2ebb9fc189a5619ec9416d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00203-023-03787-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00203-023-03787-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38191870$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Wen</creatorcontrib><creatorcontrib>Tao, Lin</creatorcontrib><creatorcontrib>Qian, Chen</creatorcontrib><creatorcontrib>Xue, Peipei</creatorcontrib><creatorcontrib>Tong, Xiankun</creatorcontrib><creatorcontrib>Yang, Li</creatorcontrib><creatorcontrib>Lu, Fang</creatorcontrib><creatorcontrib>Wan, Hua</creatorcontrib><creatorcontrib>Tao, Yingna</creatorcontrib><title>Human milk oligosaccharides and the association with microbiota in colostrum: a pilot study</title><title>Archives of microbiology</title><addtitle>Arch Microbiol</addtitle><addtitle>Arch Microbiol</addtitle><description>HMOs (Human milk oligosaccharide) has an impact on maternal and infant health. Colostrum samples of 70 breastfeeding women in China were collected and recorded clinical characteristics. The major oligosaccharides and microbiota were quantitated in colostrum. The concentration of fucosylated HMOs in primipara was higher than that of multipara (
p
= 0.030). The concentration of N-acetylated HMOs in vaginal delivery milk was less than that of cesarean (
p
= 0.038). Non-fucosylated HMOs of breastfeeding women were less than that of breast pump (
p
= 0.038). Meanwhile, the concentration of LNT was positively correlated with
Lactobacillus
(
r
= 0.250,
p
= 0.037). DS-LNT was negatively correlated with
Staphylococcus
(
r
= – 0.240,
p
= 0.045). There was a positive correlation of
Streptococcus
with LNFP II (
r
= 0.314,
p
= 0.011) and 3-SL (
r
= 0.322,
p
= 0.009). In addition, there was a negative correlation between 2'-FL and 3-FL (
r
= – 0.465,
p
= 0.001). There was a positive correlation between LNT and LNnT (
r
= 0.778,
p
= 0.001). Therefore, the concentration of HMOs is related to number of deliveries, delivery mode, lactation mode and perinatal antibiotic. The concentration of HMOs is related to
Lactobacillus
,
Streptococcus
and
Streptococcus
in colostrum. In addition, there are connections between different oligosaccharides in content. The study protocol was also registered in the ClinicalTrails.gov (ChiCTR2200064454) (Oct. 2022).</description><subject>antibiotics</subject><subject>Bacteria</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Breast feeding</subject><subject>Breast milk</subject><subject>Breastfeeding & lactation</subject><subject>breasts</subject><subject>Cell Biology</subject><subject>China</subject><subject>Colostrum</subject><subject>Correlation</subject><subject>Ecology</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Lactation</subject><subject>Lactobacillus</subject><subject>Life Sciences</subject><subject>Microbial Ecology</subject><subject>Microbiology</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Milk</subject><subject>Milk, Human</subject><subject>Oligosaccharides</subject><subject>Original Paper</subject><subject>Pilot Projects</subject><subject>Pregnancy</subject><subject>Staphylococcus</subject><subject>Streptococcus</subject><issn>0302-8933</issn><issn>1432-072X</issn><issn>1432-072X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU9vFSEUxYmxsa9Pv4ALQ-LGzegFZgZwY0xjrUmTbjQxcUEYYN6jzsATGE2_vby-Wv8s7IKwuD8O556D0FMCLwkAf5UBKLAGaD2MC96wB2hFWkYb4PTzQ7QCBrQRkrFjdJLzFQChQohH6JgJIongsEJfzpdZBzz76SuOk9_ErI3Z6uSty1gHi8vWYZ1zNF4XHwP-4cu24ibFwceisQ_YxCnmkpb5NdZ456dYcC6LvX6MjkY9Zffk9l6jT2fvPp6eNxeX7z-cvr1oTNvJ0ghqLR25A7CaOdsN0oEbGWn7YYRBEkoGp6ntDHXDIEdDhNRdT6QzsiW95WyN3hx0d8swO2tcKElPapf8rNO1itqrvyfBb9UmflcEOG9JzWeNXtwqpPhtcbmo2WfjpkkHF5esGOlY13Ii-b0orYY72jPeV_T5P-hVXFKoUewp0tdFACpFD1SNNOfkxjvjBNS-Z3XoWdWe1U3Pam_42Z8r3z35VWwF2AHIdRQ2Lv3--z-yPwEcH7Ti</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Sun, 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milk oligosaccharides and the association with microbiota in colostrum: a pilot study</title><author>Sun, Wen ; Tao, Lin ; Qian, Chen ; Xue, Peipei ; Tong, Xiankun ; Yang, Li ; Lu, Fang ; Wan, Hua ; Tao, Yingna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-82dd2f7e00da3ed5b9e0ef3146bf0b9121bea2d5c2ebb9fc189a5619ec9416d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>antibiotics</topic><topic>Bacteria</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Breast feeding</topic><topic>Breast milk</topic><topic>Breastfeeding & lactation</topic><topic>breasts</topic><topic>Cell Biology</topic><topic>China</topic><topic>Colostrum</topic><topic>Correlation</topic><topic>Ecology</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Lactation</topic><topic>Lactobacillus</topic><topic>Life Sciences</topic><topic>Microbial Ecology</topic><topic>Microbiology</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Milk</topic><topic>Milk, Human</topic><topic>Oligosaccharides</topic><topic>Original Paper</topic><topic>Pilot Projects</topic><topic>Pregnancy</topic><topic>Staphylococcus</topic><topic>Streptococcus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Wen</creatorcontrib><creatorcontrib>Tao, Lin</creatorcontrib><creatorcontrib>Qian, Chen</creatorcontrib><creatorcontrib>Xue, Peipei</creatorcontrib><creatorcontrib>Tong, Xiankun</creatorcontrib><creatorcontrib>Yang, Li</creatorcontrib><creatorcontrib>Lu, Fang</creatorcontrib><creatorcontrib>Wan, Hua</creatorcontrib><creatorcontrib>Tao, Yingna</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE 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Yingna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human milk oligosaccharides and the association with microbiota in colostrum: a pilot study</atitle><jtitle>Archives of microbiology</jtitle><stitle>Arch Microbiol</stitle><addtitle>Arch Microbiol</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>206</volume><issue>2</issue><spage>58</spage><epage>58</epage><pages>58-58</pages><artnum>58</artnum><issn>0302-8933</issn><issn>1432-072X</issn><eissn>1432-072X</eissn><abstract>HMOs (Human milk oligosaccharide) has an impact on maternal and infant health. Colostrum samples of 70 breastfeeding women in China were collected and recorded clinical characteristics. The major oligosaccharides and microbiota were quantitated in colostrum. The concentration of fucosylated HMOs in primipara was higher than that of multipara (
p
= 0.030). The concentration of N-acetylated HMOs in vaginal delivery milk was less than that of cesarean (
p
= 0.038). Non-fucosylated HMOs of breastfeeding women were less than that of breast pump (
p
= 0.038). Meanwhile, the concentration of LNT was positively correlated with
Lactobacillus
(
r
= 0.250,
p
= 0.037). DS-LNT was negatively correlated with
Staphylococcus
(
r
= – 0.240,
p
= 0.045). There was a positive correlation of
Streptococcus
with LNFP II (
r
= 0.314,
p
= 0.011) and 3-SL (
r
= 0.322,
p
= 0.009). In addition, there was a negative correlation between 2'-FL and 3-FL (
r
= – 0.465,
p
= 0.001). There was a positive correlation between LNT and LNnT (
r
= 0.778,
p
= 0.001). Therefore, the concentration of HMOs is related to number of deliveries, delivery mode, lactation mode and perinatal antibiotic. The concentration of HMOs is related to
Lactobacillus
,
Streptococcus
and
Streptococcus
in colostrum. In addition, there are connections between different oligosaccharides in content. The study protocol was also registered in the ClinicalTrails.gov (ChiCTR2200064454) (Oct. 2022).</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38191870</pmid><doi>10.1007/s00203-023-03787-3</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of microbiology, 2024-02, Vol.206 (2), p.58-58, Article 58 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | antibiotics Bacteria Biochemistry Biomedical and Life Sciences Biotechnology Breast feeding Breast milk Breastfeeding & lactation breasts Cell Biology China Colostrum Correlation Ecology Female Humans Infant Lactation Lactobacillus Life Sciences Microbial Ecology Microbiology Microbiota Microorganisms Milk Milk, Human Oligosaccharides Original Paper Pilot Projects Pregnancy Staphylococcus Streptococcus |
| title | Human milk oligosaccharides and the association with microbiota in colostrum: a pilot study |
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