Eomes-dependent mitochondrial regulation promotes survival of pathogenic CD4+ T cells during inflammation

The mechanisms whereby Eomes controls tissue accumulation of T cells and strengthens inflammation remain ill-defined. Here, we show that Eomes deletion in antigen-specific CD4+ T cells is sufficient to protect against central nervous system (CNS) inflammation. While Eomes is dispensable for the init...

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Veröffentlicht in:	The Journal of experimental medicine 2024-02, Vol.221 (2)
Hauptverfasser:	Joulia, Emeline, Michieletto, Michaël F, Agesta, Arantxa, Peillex, Cindy, Girault, Virginie, Le Dorze, Anne-Louise, Peroceschi, Romain, Bucciarelli, Florence, Szelechowski, Marion, Chaubet, Adeline, Hakim, Nawad, Marrocco, Rémi, Lhuillier, Emeline, Lebeurrier, Manuel, Argüello, Rafael J, Saoudi, Abdelhadi, El Costa, Hicham, Adoue, Veronique, Walzer, Thierry, Sarry, Jean-Emmanuel, Dejean, Anne S
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmunity CD4-Positive T-Lymphocytes Cell Death Central Nervous System Humans Inflammation Life Sciences Metabolism Mitochondria Neuroinflammation T-Box Domain Proteins - genetics
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