Efficacy of metformin combined with liraglutide on the glucose and lipid metabolism, vascular endothelial function, and oxidative stress of patients with T2DM and metabolic syndrome
This study evaluates the impact of metformin combined with liraglutide on the glucose and lipid metabolism, oxidative stress, and vascular endothelium of patients with type-2 diabetes mellitus (T2DM) and metabolic syndrome. Medical records of 78 patients with T2DM and metabolic syndrome, admitted to...
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| Veröffentlicht in: | Pakistan journal of medical sciences 2024-02, Vol.40 (1Part-I), p.26-30 |
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| description | This study evaluates the impact of metformin combined with liraglutide on the glucose and lipid metabolism, oxidative stress, and vascular endothelium of patients with type-2 diabetes mellitus (T2DM) and metabolic syndrome.
Medical records of 78 patients with T2DM and metabolic syndrome, admitted to Caoxian People's Hospital from July 2021 to July 2022, were retrospectively analysed. Thirty five patients were treated with metformin (control group), and 43 patients were treated with metformin combined with liraglutide (observation group). Indexes of glucose and lipid metabolism, function of vascular endothelium and the oxidative stress of both groups were compared before and after the treatment.
There was a significant decrease in the levels of fasting plasma glucose (FPG), Glycosylated Hemoglobin A1c (HbA1c), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP) and waist circumference in both groups three months after the treatment, These indexes were significantly lower in the observation group compared to the control group ( |
| doi_str_mv | 10.12669/pjms.40.1.7936 |
| format | Article |
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Medical records of 78 patients with T2DM and metabolic syndrome, admitted to Caoxian People's Hospital from July 2021 to July 2022, were retrospectively analysed. Thirty five patients were treated with metformin (control group), and 43 patients were treated with metformin combined with liraglutide (observation group). Indexes of glucose and lipid metabolism, function of vascular endothelium and the oxidative stress of both groups were compared before and after the treatment.
There was a significant decrease in the levels of fasting plasma glucose (FPG), Glycosylated Hemoglobin A1c (HbA1c), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP) and waist circumference in both groups three months after the treatment, These indexes were significantly lower in the observation group compared to the control group (
<0.05). High-density lipoprotein cholesterol (HDL-C) levels were higher in the observation group (
<0.05). There was a significant improvement in the levels of nitric oxide (NO), endothelin-1 (ET-1), superoxide dismutase (SOD), and malondialdehyde (MDA) after the treatment, and these indexes were markedly better in the observation group compared to the control group (P<0.05).
Metformin combined with liraglutide treatment is associated with better outcomes than metformin alone in patients with T2DM and metabolic syndrome. Combined treatment results in improved glucose and lipid metabolism, vascular endothelial function, and oxidative stress index values.</description><identifier>ISSN: 1682-024X</identifier><identifier>EISSN: 1681-715X</identifier><identifier>DOI: 10.12669/pjms.40.1.7936</identifier><identifier>PMID: 38196473</identifier><language>eng</language><publisher>Pakistan: Knowledge Bylanes</publisher><subject>Antidiabetics ; Blood pressure ; Blood sugar ; Chronic diseases ; Complications and side effects ; Diabetes ; Endothelium ; Gender ; Glucagon ; Glucose ; Glucose metabolism ; High density lipoprotein ; Hypertension ; Insulin ; Lipids ; Liraglutide ; Mental health ; Metabolic disorders ; Metabolic syndrome ; Metformin ; Original ; Oxidative stress ; Physiological aspects ; Physiology ; Smooth muscle ; Type 2 diabetes</subject><ispartof>Pakistan journal of medical sciences, 2024-02, Vol.40 (1Part-I), p.26-30</ispartof><rights>Copyright: © Pakistan Journal of Medical Sciences.</rights><rights>COPYRIGHT 2024 Knowledge Bylanes</rights><rights>(c)2024 Pakistan Journal of Medical Sciences</rights><rights>Copyright: © Pakistan Journal of Medical Sciences 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10772425/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10772425/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38196473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Zaisheng</creatorcontrib><title>Efficacy of metformin combined with liraglutide on the glucose and lipid metabolism, vascular endothelial function, and oxidative stress of patients with T2DM and metabolic syndrome</title><title>Pakistan journal of medical sciences</title><addtitle>Pak J Med Sci</addtitle><description>This study evaluates the impact of metformin combined with liraglutide on the glucose and lipid metabolism, oxidative stress, and vascular endothelium of patients with type-2 diabetes mellitus (T2DM) and metabolic syndrome.
Medical records of 78 patients with T2DM and metabolic syndrome, admitted to Caoxian People's Hospital from July 2021 to July 2022, were retrospectively analysed. Thirty five patients were treated with metformin (control group), and 43 patients were treated with metformin combined with liraglutide (observation group). Indexes of glucose and lipid metabolism, function of vascular endothelium and the oxidative stress of both groups were compared before and after the treatment.
There was a significant decrease in the levels of fasting plasma glucose (FPG), Glycosylated Hemoglobin A1c (HbA1c), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP) and waist circumference in both groups three months after the treatment, These indexes were significantly lower in the observation group compared to the control group (
<0.05). High-density lipoprotein cholesterol (HDL-C) levels were higher in the observation group (
<0.05). There was a significant improvement in the levels of nitric oxide (NO), endothelin-1 (ET-1), superoxide dismutase (SOD), and malondialdehyde (MDA) after the treatment, and these indexes were markedly better in the observation group compared to the control group (P<0.05).
Metformin combined with liraglutide treatment is associated with better outcomes than metformin alone in patients with T2DM and metabolic syndrome. Combined treatment results in improved glucose and lipid metabolism, vascular endothelial function, and oxidative stress index values.</description><subject>Antidiabetics</subject><subject>Blood pressure</subject><subject>Blood sugar</subject><subject>Chronic diseases</subject><subject>Complications and side effects</subject><subject>Diabetes</subject><subject>Endothelium</subject><subject>Gender</subject><subject>Glucagon</subject><subject>Glucose</subject><subject>Glucose metabolism</subject><subject>High density lipoprotein</subject><subject>Hypertension</subject><subject>Insulin</subject><subject>Lipids</subject><subject>Liraglutide</subject><subject>Mental health</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Metformin</subject><subject>Original</subject><subject>Oxidative stress</subject><subject>Physiological aspects</subject><subject>Physiology</subject><subject>Smooth muscle</subject><subject>Type 2 diabetes</subject><issn>1682-024X</issn><issn>1681-715X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkstuEzEUhkcIREthzQ5ZQkIsmtS3ua2qqpSLVMSmSN1ZHs9x4shjB9sTyIPxfniStjQIeWGf4-__jy-nKF4TPCe0qtqz9WqIc56jed2y6klxTKqGzGpS3j7drekMU357VLyIcYUxr3hJnxdHrCFtxWt2XPy-0tooqbbIazRA0j4MxiHlh8446NFPk5bImiAXdkymB-QdSktAOVQ-ApKuz9tr009i2Xlr4nCKNjKq0cqAwPU-49ZIi_ToVDLene5E_pfpZTIbQDEFiHGqv84JcCnuq97QD1936L2zQnHr-uAHeFk809JGeHU3nxTfP17dXH6eXX_79OXy4nqmOGNpVhJoG0YAA9G9UqTlZS11WZUd1l2JVdNhUjJeSckZxRQ46esaSt5xrgBIx06K873veuwG6FU-XJBWrIMZZNgKL4043HFmKRZ-Iwiua8ppmR3e3zkE_2OEmMRgogJrpQM_RkFbwnCTq1cZffsPuvJjcPl-gjYtrTjhlP2lFtKCME77XFhNpuKirlmLs9NEzf9D5dHDYJR3oE3OHwjePRIsQdq0jH76c-_iIXi2B1XwMQbQD69BsNj1pJh6UvAciakns-LN40d84O-bkP0BkKjgOg</recordid><startdate>20240229</startdate><enddate>20240229</enddate><creator>Liu, Zaisheng</creator><general>Knowledge Bylanes</general><general>AsiaNet Pakistan (Pvt) Ltd</general><general>Professional Medical Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240229</creationdate><title>Efficacy of metformin combined with liraglutide on the glucose and lipid metabolism, vascular endothelial function, and oxidative stress of patients with T2DM and metabolic syndrome</title><author>Liu, Zaisheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-51e9831e0e1fdcc19457af565b0fb50c8b015346aa43202e41d77e54b44cee1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antidiabetics</topic><topic>Blood pressure</topic><topic>Blood sugar</topic><topic>Chronic diseases</topic><topic>Complications and side effects</topic><topic>Diabetes</topic><topic>Endothelium</topic><topic>Gender</topic><topic>Glucagon</topic><topic>Glucose</topic><topic>Glucose metabolism</topic><topic>High density lipoprotein</topic><topic>Hypertension</topic><topic>Insulin</topic><topic>Lipids</topic><topic>Liraglutide</topic><topic>Mental health</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Metformin</topic><topic>Original</topic><topic>Oxidative stress</topic><topic>Physiological aspects</topic><topic>Physiology</topic><topic>Smooth muscle</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Zaisheng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pakistan journal of medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Zaisheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of metformin combined with liraglutide on the glucose and lipid metabolism, vascular endothelial function, and oxidative stress of patients with T2DM and metabolic syndrome</atitle><jtitle>Pakistan journal of medical sciences</jtitle><addtitle>Pak J Med Sci</addtitle><date>2024-02-29</date><risdate>2024</risdate><volume>40</volume><issue>1Part-I</issue><spage>26</spage><epage>30</epage><pages>26-30</pages><issn>1682-024X</issn><eissn>1681-715X</eissn><abstract>This study evaluates the impact of metformin combined with liraglutide on the glucose and lipid metabolism, oxidative stress, and vascular endothelium of patients with type-2 diabetes mellitus (T2DM) and metabolic syndrome.
Medical records of 78 patients with T2DM and metabolic syndrome, admitted to Caoxian People's Hospital from July 2021 to July 2022, were retrospectively analysed. Thirty five patients were treated with metformin (control group), and 43 patients were treated with metformin combined with liraglutide (observation group). Indexes of glucose and lipid metabolism, function of vascular endothelium and the oxidative stress of both groups were compared before and after the treatment.
There was a significant decrease in the levels of fasting plasma glucose (FPG), Glycosylated Hemoglobin A1c (HbA1c), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP) and waist circumference in both groups three months after the treatment, These indexes were significantly lower in the observation group compared to the control group (
<0.05). High-density lipoprotein cholesterol (HDL-C) levels were higher in the observation group (
<0.05). There was a significant improvement in the levels of nitric oxide (NO), endothelin-1 (ET-1), superoxide dismutase (SOD), and malondialdehyde (MDA) after the treatment, and these indexes were markedly better in the observation group compared to the control group (P<0.05).
Metformin combined with liraglutide treatment is associated with better outcomes than metformin alone in patients with T2DM and metabolic syndrome. Combined treatment results in improved glucose and lipid metabolism, vascular endothelial function, and oxidative stress index values.</abstract><cop>Pakistan</cop><pub>Knowledge Bylanes</pub><pmid>38196473</pmid><doi>10.12669/pjms.40.1.7936</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1682-024X |
| ispartof | Pakistan journal of medical sciences, 2024-02, Vol.40 (1Part-I), p.26-30 |
| issn | 1682-024X 1681-715X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10772425 |
| source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; PubMed Central; Alma/SFX Local Collection |
| subjects | Antidiabetics Blood pressure Blood sugar Chronic diseases Complications and side effects Diabetes Endothelium Gender Glucagon Glucose Glucose metabolism High density lipoprotein Hypertension Insulin Lipids Liraglutide Mental health Metabolic disorders Metabolic syndrome Metformin Original Oxidative stress Physiological aspects Physiology Smooth muscle Type 2 diabetes |
| title | Efficacy of metformin combined with liraglutide on the glucose and lipid metabolism, vascular endothelial function, and oxidative stress of patients with T2DM and metabolic syndrome |
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