Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells

Here, we present a gene regulation strategy enabling programmable control over eukaryotic translational initiation. By excising the natural poly-adenylation (poly-A) signal of target genes and replacing it with a synthetic control region harboring RNA-binding protein (RBP)-specific aptamers, cap-dep...

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Veröffentlicht in:	Cell research 2024-01, Vol.34 (1), p.31-46
Hauptverfasser:	Shao, Jiawei, Li, Shichao, Qiu, Xinyuan, Jiang, Jian, Zhang, Lihang, Wang, Pengli, Si, Yaqing, Wu, Yuhang, He, Minghui, Xiong, Qiqi, Zhao, Liuqi, Li, Yilin, Fan, Yuxuan, Viviani, Mirta, Fu, Yu, Wu, Chaohua, Gao, Ting, Zhu, Lingyun, Fussenegger, Martin, Wang, Hui, Xie, Mingqi
Format:	Artikel
Sprache:	eng
Schlagworte:	14/10 38/47 631/337/2179 631/67/1059/602 Animals Biomedical and Life Sciences Carrier Proteins - metabolism Cell Biology Diabetes Mellitus, Experimental Eukaryotic Initiation Factor-4F - metabolism Gene Expression Regulation Life Sciences Mammals Mice Protein Processing, Post-Translational
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