Modulation of autophagy and apoptosis can contribute to the anticancer effect of Abemaciclib/Celecoxib combination in colon cancer cells

Drug resistance and recurrence represent a great challenge in colorectal cancer management, highlighting the urgent need for novel therapeutics. Our objective is to evaluate the influence of Abemaciclib, Celecoxib, and their combination on both the autophagic and apoptotic machinery in an attempt to...

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Veröffentlicht in:	Medical oncology (Northwood, London, England) London, England), 2024-01, Vol.41 (2), p.43, Article 43
Hauptverfasser:	Alian, Dalia Mohamed Elsayed, Helmy, Maged W., Haroun, Medhat, Moussa, Nermine
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Autophagy Beclin-1 - pharmacology Caco-2 Cells Cancer therapies Caspase 3 - metabolism Celecoxib - pharmacology Celecoxib - therapeutic use Cell cycle Cell Line, Tumor Colonic Neoplasms - pathology Colorectal cancer Gene expression Hematology Humans Internal Medicine Medicine Medicine & Public Health Oncology Original Paper Pathology Proto-Oncogene Proteins c-bcl-2 - metabolism
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