CDKL5 regulates p62-mediated selective autophagy and confers protection against neurotropic viruses

Virophagy, the selective autophagosomal engulfment and lysosomal degradation of viral components, is crucial for neuronal cell survival and antiviral immunity. However, the mechanisms leading to viral antigen recognition and capture by autophagic machinery remain poorly understood. Here, we identifi...

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Veröffentlicht in:	The Journal of clinical investigation 2024-01, Vol.134 (1), p.1-17
Hauptverfasser:	Thinwa, Josephine W, Zou, Zhongju, Parks, Emily, Sebti, Salwa, Hui, Kelvin, Wei, Yongjie, Goodarzi, Mohammad, Singh, Vibha, Urquhart, Greg, Jewell, Jenna L, Pfeiffer, Julie K, Levine, Beth, Reese, Tiffany A, Shiloh, Michael U
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Antiviral agents Arthropods Autophagy Autophagy (Cytology) Biomedical research Capsid protein Capsids Cell death Cell survival Chikungunya virus Cloning Cyclin-dependent kinase Cyclin-dependent kinases Cytotoxicity Dosage and administration Encephalopathy Gene mutations Health aspects Herpes viruses Inclusion bodies Infections International economic relations Intracellular Kinases Lethality Lysosomes Mutation Neurodevelopment Neurons Phosphorylation Proteins RNA viruses Scientific equipment and supplies industry Testing Viral antigens Viral infections Viral proteins
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