Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy

Iron overload and ferroptosis are associated with intervertebral disc degeneration (IDD); however, the mechanism underlying the regulation of iron homeostasis remains to be elucidated. Nuclear factor erythroid 2‑related factor 2 (Nrf2) has been reported to regulate cellular iron homeostasis; however...

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Veröffentlicht in:	International journal of molecular medicine 2024-02, Vol.53 (2), p.1, Article 17
Hauptverfasser:	Ma, Zhenkai, Lu, Hui, Feng, Xuemin, Du, Ting, Li, Jianhua, Zhang, Qiang, Gu, Xindong, Shao, Yuandong, Jing, Xingzhi, Su, Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcinosis - metabolism Cartilage Cartilage - metabolism Cell death Chondrocytes - metabolism Ferroptosis Homeostasis Humans Immunohistochemistry Intervertebral Disc Degeneration - genetics Intervertebral Disc Degeneration - metabolism Iron - metabolism Iron compounds Laboratories Metabolism NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nuclear Receptor Coactivators - metabolism Nutrition Older people Optical instruments industry Oxidative stress Proteins Regulation Scientific equipment and supplies industry
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