Leveraging Tissue-Specific Enhancer-Target Gene Regulatory Networks Identifies Enhancer Somatic Mutations That Functionally Impact Lung Cancer

Enhancers are noncoding regulatory DNA regions that modulate the transcription of target genes, often over large distances along with the genomic sequence. Enhancer alterations have been associated with various pathological conditions, including cancer. However, the identification and characterizati...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2024-01, Vol.84 (1), p.133-153
Hauptverfasser:	Hariprakash, Judith Mary, Salviato, Elisa, La Mastra, Federica, Sebestyén, Endre, Tagliaferri, Ilario, Silva, Raquel Sofia, Lucini, Federica, Farina, Lorenzo, Cinquanta, Mario, Rancati, Ilaria, Riboni, Mirko, Minardi, Simone Paolo, Roz, Luca, Gorini, Francesca, Lanzuolo, Chiara, Casola, Stefano, Ferrari, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Landscapes Carcinogenesis - genetics Enhancer Elements, Genetic - genetics Epigenetics Gene Regulation Gene Regulatory Networks Genome Biology Humans Lung Neoplasms - genetics Mutation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!