Listerin promotes cGAS protein degradation through the ESCRT pathway to negatively regulate cGAS-mediated immune response

The enzyme cyclic GMP-AMP synthase (cGAS) is a key sensor for detecting misplaced double-stranded DNA (dsDNA) of genomic, mitochondrial, and microbial origin. It synthesizes 2'3'-cGAMP, which in turn activates the stimulator of interferon genes pathway, leading to the initiation of innate...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-12, Vol.120 (52), p.e2308853120
Hauptverfasser:	Qin, Fei, Cai, Baoshan, Cao, Runyu, Bai, Xuemei, Yuan, Jiahua, Zhang, Yuling, Liu, Yaxing, Chen, Tian, Liu, Feng, Sun, Wanwei, Zheng, Yi, Qi, Xiaopeng, Zhao, Wei, Liu, Bingyu, Gao, Chengjiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic Lateral Sclerosis Animals Biodegradation Biological Sciences Degradation Endosomal Sorting Complexes Required for Transport - metabolism Endosomes Herpes simplex Immune response Immune system Immunity, Innate - genetics Inflammation Innate immunity Mice Microorganisms Mitochondrial DNA Nucleotidyltransferases - metabolism Proteolysis Signal Transduction - physiology Stimulators Therapeutic targets Ubiquitin-protein ligase Ubiquitination
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